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学科主题: 药物依赖
题名:
Potentiating effect of tramadol on methamphetamine-induced behavioral sensitization in mice
作者: Liang, JH; Wang, K; Sun, HL; Han, R
关键词: tramadol ; methamphetamine ; hyperlocomotion ; sensitization
刊名: PSYCHOPHARMACOLOGY
发表日期: 2006-03-01
DOI: 10.1007/s00213-005-0260-8
卷: 185, 期:1, 页:1-10
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
研究领域[WOS]: Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
关键词[WOS]: INDUCED LOCOMOTOR-ACTIVITY ; HIPPOCAMPAL ALPHA(2A)-ADRENERGIC RECEPTOR ; CONDITIONED PLACE PREFERENCE ; D-AMPHETAMINE ; NUCLEUS-ACCUMBENS ; RAT-BRAIN ; ALPHA-1-ADRENERGIC RECEPTORS ; CORTICAL SYNAPTOSOMES ; DOPAMINE RELEASE ; DRUG-DEPENDENCE
英文摘要:

Rationale: Polydrug abuse is a common phenomenon in human drug addicts. Previous studies have shown that both tramadol (TRAM) and methamphetamine (METH) share the ability to modulate brain monoaminergic (dopamine, 5-hydroxytryptamine, and noradrenaline) systems that may be involved in behavioral sensitization to METH. Therefore, we hypothesized that there would be an interaction between TRAM and METH on behavioral sensitization induced by METH. Objectives: To investigate whether TRAM affects METH-induced behavioral sensitization. Methods: Male Kunming mice were subjected to two regimens of drugs: (1) Mice were injected with TRAM (1-16 mg/kg, i.p.) alone or a combination of TRAM and METH (1 mg/kg, i.p.) once daily for 7 days. After 7 drug-free days (on day 15), animals were challenged with the corresponding TRAM dose or METH (1 mg/kg, i.p.). On days 1, 7, and 15, locomotion was monitored in the open field test after the last injection. (2) Mice received METH (1 mg/kg, i.p.) once daily for 7 days, followed by 7 drug-free days. On day 15, a challenge of TRAM (1-16 mg/ kg, i.p.) or TRAM plus METH (1 mg/ kg, i.p.) was given and then locomotor activity was quantified. Results: TRAM or METH challenge did not induce hyperlocomotion in mice chronically treated with TRAM, and TRAM challenge was insufficient to induce subsequent hyperlocomotion in METH-sensitized mice. However, TRAM significantly increased METH-induced hyperlocomotion. TRAM plus METH-sensitized mice showed a significantly greater hyperlocomotor response to METH challenge than METH-sensitized mice. Furthermore, TRAM (16 mg/ kg, i.p.) plus METH (1 mg/ kg, i.p.) challenge enhanced the sensitized locomotor response compared to METH-alone (1 mg/ kg, i.p.) challenge in METH-sensitized mice. Conclusions: TRAM fails to produce behavioral sensitization, and there is no apparent cross-sensitization between TRAM and METH. However, TRAM can increase METH-induced hyperlocomotion and potentiate the development and expression of behavioral sensitization to METH.

语种: 英语
WOS记录号: WOS:000235547600001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56011
Appears in Collections:中国药物依赖性研究所_期刊论文

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作者单位: Peking Univ, Natl Inst Drug Dependence, Dept Neuropharmacol, Beijing 100083, Peoples R China

Recommended Citation:
Liang, JH,Wang, K,Sun, HL,et al. Potentiating effect of tramadol on methamphetamine-induced behavioral sensitization in mice[J]. PSYCHOPHARMACOLOGY,2006,185(1):1-10.
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