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IR@PKUHSC  > 北京大学深圳医院  > 神经内科  > 期刊论文
学科主题: 临床医学
题名:
Effects of integrins and integrin alpha v beta 3 inhibitor on angiogenesis in cerebral ischemic stroke
作者: Bi, Jia-jia; Yi, Li
关键词: integrin alpha v beta 3 ; cerebral ischemic stroke ; vascular endothelial growth factor ; cyclo [Arg-Gly-Asp-D-Phe-Val]
刊名: JOURNAL OF HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY-MEDICAL SCIENCES
发表日期: 2014-06-01
DOI: 10.1007/s11596-014-1274-4
卷: 34, 期:3, 页:299-305
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology
研究领域[WOS]: Biochemistry & Molecular Biology
关键词[WOS]: ENDOTHELIAL GROWTH-FACTOR ; POSITRON-EMISSION-TOMOGRAPHY ; BLOOD-BRAIN-BARRIER ; ARTERY OCCLUSION ; ALPHA(V)BETA(3)-INTEGRIN EXPRESSION ; PLASMINOGEN-ACTIVATOR ; EXTRACELLULAR-MATRIX ; TUMOR ANGIOGENESIS ; NERVOUS-SYSTEM ; IN-VITRO
英文摘要:

Integrins such as alpha v beta 3, alpha 5 beta 1 play a key role in angiogenesis regulation, invasion and metastasis, inflammation, wound healing, etc. The up-regulation of integrin alpha v beta 3 after cerebral ischemic stroke can promote angiogenesis, which in turn improves functional recovery. In addition, the integrin alpha v beta 3 inhibitor can block the blood-brain barrier (BBB) leakage induced by vascular endothelial growth factor (VEGF) and also can reduce inflammatory reaction, decrease the deposition of fibrinogen. Other studies showed that integrin alpha v beta 3 is not essential in revascularization. Therefore, the effect of integrin alpha v beta 3 in the whole process of brain function recovery merits further study.

语种: 英语
WOS记录号: WOS:000338209800001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56020
Appears in Collections:北京大学深圳医院_神经内科_期刊论文

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作者单位: Peking Univ, Dept Neurol, Shenzhen Hosp, Shenzhen 518036, Peoples R China

Recommended Citation:
Bi, Jia-jia,Yi, Li. Effects of integrins and integrin alpha v beta 3 inhibitor on angiogenesis in cerebral ischemic stroke[J]. JOURNAL OF HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY-MEDICAL SCIENCES,2014,34(3):299-305.
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