IR@PKUHSC  > 北京大学深圳医院  > 神经内科
学科主题临床医学
Effects of integrins and integrin alpha v beta 3 inhibitor on angiogenesis in cerebral ischemic stroke
Bi, Jia-jia; Yi, Li
关键词Integrin Alpha v Beta 3 Cerebral Ischemic Stroke Vascular Endothelial Growth Factor Cyclo [Arg-gly-asp-d-phe-val]
刊名JOURNAL OF HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY-MEDICAL SCIENCES
2014-06-01
DOI10.1007/s11596-014-1274-4
34期:3页:299-305
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology
研究领域[WOS]Biochemistry & Molecular Biology
关键词[WOS]ENDOTHELIAL GROWTH-FACTOR ; POSITRON-EMISSION-TOMOGRAPHY ; BLOOD-BRAIN-BARRIER ; ARTERY OCCLUSION ; ALPHA(V)BETA(3)-INTEGRIN EXPRESSION ; PLASMINOGEN-ACTIVATOR ; EXTRACELLULAR-MATRIX ; TUMOR ANGIOGENESIS ; NERVOUS-SYSTEM ; IN-VITRO
英文摘要

Integrins such as alpha v beta 3, alpha 5 beta 1 play a key role in angiogenesis regulation, invasion and metastasis, inflammation, wound healing, etc. The up-regulation of integrin alpha v beta 3 after cerebral ischemic stroke can promote angiogenesis, which in turn improves functional recovery. In addition, the integrin alpha v beta 3 inhibitor can block the blood-brain barrier (BBB) leakage induced by vascular endothelial growth factor (VEGF) and also can reduce inflammatory reaction, decrease the deposition of fibrinogen. Other studies showed that integrin alpha v beta 3 is not essential in revascularization. Therefore, the effect of integrin alpha v beta 3 in the whole process of brain function recovery merits further study.

语种英语
WOS记录号WOS:000338209800001
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56020
专题北京大学深圳医院_神经内科
作者单位Peking Univ, Dept Neurol, Shenzhen Hosp, Shenzhen 518036, Peoples R China
推荐引用方式
GB/T 7714
Bi, Jia-jia,Yi, Li. Effects of integrins and integrin alpha v beta 3 inhibitor on angiogenesis in cerebral ischemic stroke[J]. JOURNAL OF HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY-MEDICAL SCIENCES,2014,34(3):299-305.
APA Bi, Jia-jia,&Yi, Li.(2014).Effects of integrins and integrin alpha v beta 3 inhibitor on angiogenesis in cerebral ischemic stroke.JOURNAL OF HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY-MEDICAL SCIENCES,34(3),299-305.
MLA Bi, Jia-jia,et al."Effects of integrins and integrin alpha v beta 3 inhibitor on angiogenesis in cerebral ischemic stroke".JOURNAL OF HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY-MEDICAL SCIENCES 34.3(2014):299-305.
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