北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学临床肿瘤学院  > 胃肠肿瘤中心  > 期刊论文
学科主题: 临床医学
题名:
Whole Genome Gene Copy Number Profiling of Gastric Cancer Identifies PAK1 and KRAS Gene Amplification as Therapy Targets
作者: Qian, Ziliang1; Zhu, Guanshan1; Tang, Lili1; Wang, Mei1; Zhang, Lianhai2; Fu, Jiangang1; Huang, Chunlei1; Fan, Shuqiong1; Sun, Yun1; Lv, Jing1; Dong, Hua1; Gao, Beirong1; Su, Xinying1; Yu, Dehua1; Zang, Jie1; Zhang, Xiaolin1; Ji, Jiafu2; Ji, Qunsheng1
刊名: GENES CHROMOSOMES & CANCER
发表日期: 2014-11-01
DOI: 10.1002/gcc.22196
卷: 53, 期:11, 页:883-894
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Genetics & Heredity
研究领域[WOS]: Oncology ; Genetics & Heredity
关键词[WOS]: POSITIVE LYMPH-NODES ; PAN-FGFR INHIBITOR ; PHASE-III TRIAL ; MET AMPLIFICATION ; ADENOCARCINOMA ; PROGNOSIS ; CARCINOMA ; OVEREXPRESSION ; SENSITIVITY ; RESECTION
英文摘要:

Gastric cancer is the second leading cause of death from cancer worldwide, with an approximately 20% 5-year survival rate. To identify molecular subtypes associated with the clinical prognosis, in addition to genetic aberrations for potential targeted therapeutics, we conducted a comprehensive whole-genome analysis of 131 Chinese gastric cancer tissue specimens using whole-genome array comparative genomic hybridization. The analyses revealed gene focal amplifications, including CTSB, PRKCI, PAK1, STARD13, KRAS, and ABCC4, in addition to ERBB2, FGFR2, and MET. The growth of PAK1-amplified gastric cancer cells in vitro and in vivo was inhibited when the corresponding mRNA was knocked down. Furthermore, both KRAS amplification and KRAS mutation were identified in the gastric cancer specimens. KRAS amplification was associated with worse clinical outcomes, and the KRAS gene mutation predicted sensitivity to the MEK1/2 inhibitor AZD6244 in gastric cancer cell lines. In summary, amplified PAK1, as well as KRAS amplification/mutation, may represent unique opportunities for developing targeted therapeutics for the treatment of gastric cancer. (c) 2014 Wiley Periodicals, Inc.

语种: 英语
WOS记录号: WOS:000342158500001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56021
Appears in Collections:北京大学临床肿瘤学院_胃肠肿瘤中心_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.AstraZeneca Innovat Med & Early Dev, Innovat Ctr China Asia & Emerging Market iMed, Shanghai 201203, Peoples R China
2.Beijing Canc Hosp & Inst, Dept Gastrointestinal Surg, Key Lab Carcinogenesis & Translat Res, Minist Educ, Beijing 100142, Peoples R China

Recommended Citation:
Qian, Ziliang,Zhu, Guanshan,Tang, Lili,et al. Whole Genome Gene Copy Number Profiling of Gastric Cancer Identifies PAK1 and KRAS Gene Amplification as Therapy Targets[J]. GENES CHROMOSOMES & CANCER,2014,53(11):883-894.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Qian, Ziliang]'s Articles
[Zhu, Guanshan]'s Articles
[Tang, Lili]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Qian, Ziliang]‘s Articles
[Zhu, Guanshan]‘s Articles
[Tang, Lili]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2018  北京大学医学部 - Feedback
Powered by CSpace