北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第二临床医学院  > 北京大学肝病研究所  > 期刊论文
学科主题: 临床医学
题名:
Clinical and Epidemiologic Characteristics of Norovirus GII.4 Sydney during Winter 2012-13 in Beijing, China following Its Global Emergence
作者: Mai, Huan1; Jin, Miao2; Guo, XiaoLin1; Liu, Jian3; Liu, Ning3; Cong, Xu4; Gao, Yan1; Wei, Lai4
刊名: PLOS ONE
发表日期: 2013-08-16
DOI: 10.1371/journal.pone.0071483
卷: 8, 期:8
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: SPORADIC GASTROENTERITIS ; VARIANT
英文摘要:

Background: Limited information is available on the molecular epidemiology of GII.4 Sydney-associated diarrhea in China in the winter of 2012-13 during the global epidemic associated with the emergence of GII.4 Sydney.

Methods: Fecal specimens collected from 171 diarrhea outpatients (one from each) between late October 2012 and the middle of March 2013 were examined for NoV by reverse transcription-polymerase chain reaction and sequences corresponding to both the NoV partial polymerase and partial capsid regions were analyzed phylogenetically. Clinical characteristics of GII.4 Sydney cases versus other NoV-positive cases detected in a previous study were compared statistically.

Results: Twenty-six (15.2%, 26/171) outpatients with diarrhea were infected with NoV. Twenty-two of the 26 (84.6%) identified NoV strains clustered into GII.4 Sydney. There was a significant difference in symptoms of fever (chi(2), P < 0.05), abdominal pain (chi(2), P<0.05) and diarrhea frequency (Mann-Whitney U test, P<0.05) between the GII.4 Sydney case group and other NoV-positive case group.

Conclusions: The new NoV variant, GII.4 Sydney, has been circulating in Beijing, China and became the predominant strain in the winter of 2012-13. GII.4 Sydney causes severe fever, abdominal pain and higher diarrhea frequency clinically compared to other NoV infections.

语种: 英语
所属项目编号: 2012ZX10004215 ; 81000727
项目资助者: Key Project of Science and Technology, People&prime ; s Republic of China
WOS记录号: WOS:000323570200032
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56026
Appears in Collections:北京大学第二临床医学院_北京大学肝病研究所_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Peking Univ Peoples Hosp, Inst Hepatol, Dept Infect Dis, Beijing 100871, Peoples R China
2.Natl Inst Viral Dis Control & Prevent, Chinese Ctr Dis Control & Prevent, Beijing, Peoples R China
3.Peking Univ Peoples Hosp, Dept Clin Lab, Beijing, Peoples R China
4.Peking Univ, Peking Univ Peoples Hosp, Inst Hepatol, Beijing 100871, Peoples R China

Recommended Citation:
Mai, Huan,Jin, Miao,Guo, XiaoLin,et al. Clinical and Epidemiologic Characteristics of Norovirus GII.4 Sydney during Winter 2012-13 in Beijing, China following Its Global Emergence[J]. PLOS ONE,2013,8(8).
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Mai, Huan]'s Articles
[Jin, Miao]'s Articles
[Guo, XiaoLin]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Mai, Huan]‘s Articles
[Jin, Miao]‘s Articles
[Guo, XiaoLin]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace