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Study on the interaction of human immunodeficiency virus inhibitor, trans-activitor of transcription protein and ribonucleic acid system by capillary electrophoresis
Qi, XH; Ding, L; Zhang, XX; Cheng, WB
关键词Capillary Electrophoresis Human Immunodeficiency Virus Inhibitor Trans-activitor Of Transcription Protein Ribonucleic Acid Binding Constant
刊名CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
2005-02-01
33期:2页:214-216
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Analytical
研究领域[WOS]Chemistry
英文摘要

The reagents and products of the competitive reaction of a new type of human immunodeficency virus ( HIV) inhibitor (beta-carboline drug), HIV trans-activitor of transcription (Tat) protein and HIV transactivitor response region (TAR RNA) by capillary zone electrophoresis were separated, and the interaction of HIV inhibitor and RNA was studied. The combining ratio of 1: 1 was determined. In addition, the binding constant of the interaction was 2.76 X 10(4) L/mol, and it was the same as that of Tat protein and RNA. The HIV inhibitor interacted with RNA with competitive reaction of Tat protein, and it restrained virus reproduction effectively. The result was consistent with that of biology method.

语种中文
WOS记录号WOS:000227651300017
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56027
专题北京大学药学院
作者单位1.Peking Univ, Coll Chem, Beijing 100871, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Qi, XH,Ding, L,Zhang, XX,et al. Study on the interaction of human immunodeficiency virus inhibitor, trans-activitor of transcription protein and ribonucleic acid system by capillary electrophoresis[J]. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,2005,33(2):214-216.
APA Qi, XH,Ding, L,Zhang, XX,&Cheng, WB.(2005).Study on the interaction of human immunodeficiency virus inhibitor, trans-activitor of transcription protein and ribonucleic acid system by capillary electrophoresis.CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,33(2),214-216.
MLA Qi, XH,et al."Study on the interaction of human immunodeficiency virus inhibitor, trans-activitor of transcription protein and ribonucleic acid system by capillary electrophoresis".CHINESE JOURNAL OF ANALYTICAL CHEMISTRY 33.2(2005):214-216.
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