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学科主题: 药学
题名:
Study on the interaction of human immunodeficiency virus inhibitor, trans-activitor of transcription protein and ribonucleic acid system by capillary electrophoresis
作者: Qi, XH; Ding, L; Zhang, XX; Cheng, WB
关键词: capillary electrophoresis ; human immunodeficiency virus inhibitor ; trans-activitor of transcription protein ; ribonucleic acid ; binding constant
刊名: CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
发表日期: 2005-02-01
卷: 33, 期:2, 页:214-216
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Analytical
研究领域[WOS]: Chemistry
英文摘要:

The reagents and products of the competitive reaction of a new type of human immunodeficency virus ( HIV) inhibitor (beta-carboline drug), HIV trans-activitor of transcription (Tat) protein and HIV transactivitor response region (TAR RNA) by capillary zone electrophoresis were separated, and the interaction of HIV inhibitor and RNA was studied. The combining ratio of 1: 1 was determined. In addition, the binding constant of the interaction was 2.76 X 10(4) L/mol, and it was the same as that of Tat protein and RNA. The HIV inhibitor interacted with RNA with competitive reaction of Tat protein, and it restrained virus reproduction effectively. The result was consistent with that of biology method.

语种: 中文
WOS记录号: WOS:000227651300017
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56027
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Coll Chem, Beijing 100871, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Beijing 100083, Peoples R China

Recommended Citation:
Qi, XH,Ding, L,Zhang, XX,et al. Study on the interaction of human immunodeficiency virus inhibitor, trans-activitor of transcription protein and ribonucleic acid system by capillary electrophoresis[J]. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,2005,33(2):214-216.
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