IR@PKUHSC  > 北京大学基础医学院
学科主题基础医学
Activating transcription factor 4 is involved in endoplasmic reticulum stress-mediated apoptosis contributing to vascular calcification
Duan, Xiao-Hui1; Chang, Jin-Rui2,3; Zhang, Jing4; Zhang, Bao-Hong5; Li, Yu-Lin1; Teng, Xu1; Zhu, Yi2,3; Du, Jie1; Tang, Chao-Shu1,2,3; Qi, Yong-Fen1,3
关键词Activating Transcription Factor 4 Endoplasmic Reticulum Stress Apoptosis Vascular Calcification
刊名APOPTOSIS
2013-09-01
DOI10.1007/s10495-013-0861-3
18期:9页:1132-1144
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Cell Biology
研究领域[WOS]Biochemistry & Molecular Biology ; Cell Biology
关键词[WOS]UNFOLDED PROTEIN RESPONSE ; SMOOTH-MUSCLE-CELLS ; CHEMICAL CHAPERONES ; TAURINE PREVENTS ; MODEL ; MECHANISMS ; EXPRESSION
英文摘要

Our previous work reported that endoplasmic reticulum stress (ERS)-mediated apoptosis was activated during vascular calcification (VC). Activating transcription factor 4 (ATF4) is a critical transcription factor in osteoblastogenesis and ERS-induced apoptosis. However, whether ATF4 is involved in ERS-mediated apoptosis contributing to VC remains unclear. In the present study, in vivo VC was induced in rats by administering vitamin D-3 plus nicotine. Vascular smooth muscle cell (VSMC) calcification in vitro was induced by incubation in calcifying media containing beta-glycerophosphate and CaCl2. ERS inhibitors taurine or 4-phenylbutyric acid attenuated ERS and VSMC apoptosis in calcified rat arteries, reduced calcification and retarded the VSMC contractile phenotype transforming into an osteoblast-like phenotype in vivo. Inhibition of ERS retarded the VSMC phenotypic transition into an osteoblast-like cell phenotype and reduced VSMC calcification and apoptosis in vitro. Interestingly, ATF4 was activated in calcified aortas and calcified VSMCs in vitro. ATF4 knockdown attenuated ERS-induced apoptosis in calcified VSMCs. ATF4 deficiency blocked VSMC calcification and negatively regulated the osteoblast phenotypic transition of VSMCs in vitro. Our results demonstrate that ATF4 was involved at least in part in the process of ERS-mediated apoptosis contributing to VC.

语种英语
WOS记录号WOS:000322664700010
项目编号81270407 ; 81170082 ; 20110001110012
资助机构National Natural Science Foundation of China ; Ministry of Education Foundation for Doctoral Tutor
引用统计
被引频次:24[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56028
专题北京大学基础医学院
作者单位1.Capital Med Univ, Key Lab Remodeling Related Cardiovasc Dis, Minist Educ, Beijing An Zhen Hosp, Beijing 100029, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Physiol & Pathophysiol, Sch Basic Med Sci, Beijing 100191, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Key Lab Mol Cardiovasc Sci, Minist Educ, Beijing 100191, Peoples R China
4.Beijing Normal Univ, Sch PE & Sports Sci, Beijing 100875, Peoples R China
5.Hosp Tsinghua Univ, Beijing 100084, Peoples R China
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GB/T 7714
Duan, Xiao-Hui,Chang, Jin-Rui,Zhang, Jing,et al. Activating transcription factor 4 is involved in endoplasmic reticulum stress-mediated apoptosis contributing to vascular calcification[J]. APOPTOSIS,2013,18(9):1132-1144.
APA Duan, Xiao-Hui.,Chang, Jin-Rui.,Zhang, Jing.,Zhang, Bao-Hong.,Li, Yu-Lin.,...&Qi, Yong-Fen.(2013).Activating transcription factor 4 is involved in endoplasmic reticulum stress-mediated apoptosis contributing to vascular calcification.APOPTOSIS,18(9),1132-1144.
MLA Duan, Xiao-Hui,et al."Activating transcription factor 4 is involved in endoplasmic reticulum stress-mediated apoptosis contributing to vascular calcification".APOPTOSIS 18.9(2013):1132-1144.
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