IR@PKUHSC  > 北京大学第一临床医学院  > 男科中心
学科主题临床医学
Study of Clinical Practical Model of Urinary System Injury
Li, Gang1; Wu, Yuan-Yi2; Fu, Wei-Jun3; Jia, Ying-Xin4; Zhang, Bing-Hong5; Xu, Yong-De6; Wang, Zhong-Xin3; Shi, Jian-Guo7; Tan, Hai-Song7; Qian, Ye-Yong1; Shi, Bin-Yi1; Zhang, Chao-Hua8; Wang, Xiao-Xiong7
关键词Animal Injury Models Urogenital System Wound Generator
刊名CHINESE MEDICAL JOURNAL
2015-04-05
DOI10.4103/0366-6999.154299
128期:7页:928-932
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]URETHRAL EPITHELIAL-CELLS ; STENT
英文摘要

Background: In order to improve the clinical treatment level of urinary system injury, it is necessary to build up an animal model of urinary system wound, which is not only analogous to real clinical practice, but also simple and practical.

Methods: We have developed the third generation of firearm fragment wound generator based on the first and the second producer. The best explosive charge of the blank cartridge was selected by gradient powder loading experiments. The firearm fragment injuries were made to the bulbous urethra of 10 New Zealand male rabbits. One week preoperatively and 2, 4 and 8 weeks postoperatively, all the animals underwent urethroscopy and urethrography. At 2, 4 and 8 weeks postoperatively, two animals were randomly selected and killed, and the urethra was cut off for pathological examination.

Results: The shooting distance of the third generation of firearm fragment wound generator is 2 cm. The best explosive charge of the blank cartridge is 1 g of nitrocotton. All rabbits survived the procedures and stayed alive until they were killed. Injuries were limited to bulbous urethra and distal urethra. Round damaged areas, 1-1.5 cm in length, on the ventral wall were observed. Ureteroscopy results showed that canal diameter gradually shrank by over 50% in 9 rabbits. The rate of success was 90%. Urethrography result noted that a 1-1.3 cm stricture was formed at the bulbous urethra. Histology results of injured stricture urethra showed that fibrous connective tissue hyperplasia and hyaline degeneration caused further stricture in the canal.

Conclusions: The third generation of firearm fragment wound generator imitates the bullet firing process and is more accurate and repeatable. The corresponding rabbit model of traumatic complex urethral stricture simulates the real complex clinical conditions. This animal model provides a standardized platform for clinical researches on treating traumatic injuries to the urinary system.

语种英语
WOS记录号WOS:000352533500013
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56030
专题北京大学第一临床医学院_男科中心
作者单位1.309 Hosp PLA, Inst Organ Transplant Chinese PLA, Beijing 100091, Peoples R China
2.Chinese Peoples Liberat Army Gen Hosp, Affiliated Hosp 1, Dept Urol, Beijing 100048, Peoples R China
3.Peking Univ, Hosp 1, Androl Ctr, Beijing 100034, Peoples R China
4.Baoding First Hosp, Dept Urol, Baoding 071000, Peoples R China
5.Chinese Peoples Liberat Army Gen Hosp, Hainan Branch, Dept Urol, Sanya 572013, Hainan, Peoples R China
6.Acad Armoured Force Engn, Mil Dept, Beijing 100072, Peoples R China
7.Gen Hosp Chengdu Mil Command, Dept Urinary, Chengdu 610083, Sichuan, Peoples R China
8.Chinese Peoples Liberat Army Gen Hosp, Dept Urol, Beijing 100853, Peoples R China
推荐引用方式
GB/T 7714
Li, Gang,Wu, Yuan-Yi,Fu, Wei-Jun,et al. Study of Clinical Practical Model of Urinary System Injury[J]. CHINESE MEDICAL JOURNAL,2015,128(7):928-932.
APA Li, Gang.,Wu, Yuan-Yi.,Fu, Wei-Jun.,Jia, Ying-Xin.,Zhang, Bing-Hong.,...&Wang, Xiao-Xiong.(2015).Study of Clinical Practical Model of Urinary System Injury.CHINESE MEDICAL JOURNAL,128(7),928-932.
MLA Li, Gang,et al."Study of Clinical Practical Model of Urinary System Injury".CHINESE MEDICAL JOURNAL 128.7(2015):928-932.
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