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学科主题: 临床医学
题名:
Study of Clinical Practical Model of Urinary System Injury
作者: Li, Gang1; Wu, Yuan-Yi2; Fu, Wei-Jun3; Jia, Ying-Xin4; Zhang, Bing-Hong5; Xu, Yong-De6; Wang, Zhong-Xin3; Shi, Jian-Guo7; Tan, Hai-Song7; Qian, Ye-Yong1; Shi, Bin-Yi1; Zhang, Chao-Hua8; Wang, Xiao-Xiong7
关键词: Animal ; Injury ; Models ; Urogenital System ; Wound Generator
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2015-04-05
DOI: 10.4103/0366-6999.154299
卷: 128, 期:7, 页:928-932
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: URETHRAL EPITHELIAL-CELLS ; STENT
英文摘要:

Background: In order to improve the clinical treatment level of urinary system injury, it is necessary to build up an animal model of urinary system wound, which is not only analogous to real clinical practice, but also simple and practical.

Methods: We have developed the third generation of firearm fragment wound generator based on the first and the second producer. The best explosive charge of the blank cartridge was selected by gradient powder loading experiments. The firearm fragment injuries were made to the bulbous urethra of 10 New Zealand male rabbits. One week preoperatively and 2, 4 and 8 weeks postoperatively, all the animals underwent urethroscopy and urethrography. At 2, 4 and 8 weeks postoperatively, two animals were randomly selected and killed, and the urethra was cut off for pathological examination.

Results: The shooting distance of the third generation of firearm fragment wound generator is 2 cm. The best explosive charge of the blank cartridge is 1 g of nitrocotton. All rabbits survived the procedures and stayed alive until they were killed. Injuries were limited to bulbous urethra and distal urethra. Round damaged areas, 1-1.5 cm in length, on the ventral wall were observed. Ureteroscopy results showed that canal diameter gradually shrank by over 50% in 9 rabbits. The rate of success was 90%. Urethrography result noted that a 1-1.3 cm stricture was formed at the bulbous urethra. Histology results of injured stricture urethra showed that fibrous connective tissue hyperplasia and hyaline degeneration caused further stricture in the canal.

Conclusions: The third generation of firearm fragment wound generator imitates the bullet firing process and is more accurate and repeatable. The corresponding rabbit model of traumatic complex urethral stricture simulates the real complex clinical conditions. This animal model provides a standardized platform for clinical researches on treating traumatic injuries to the urinary system.

语种: 英语
所属项目编号: 81070555 ; 2092029 ; 7142145 ; 413DG63J ; 06MA298
项目资助者: National Natural Science Foundation of China ; Beijing Natural Science Foundation ; Major Project of Clinical High and New Technology of PLA ; Eleventh Five-year subject of the surface of the whole army project
WOS记录号: WOS:000352533500013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56030
Appears in Collections:北京大学第一临床医学院_男科中心_期刊论文

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作者单位: 1.309 Hosp PLA, Inst Organ Transplant Chinese PLA, Beijing 100091, Peoples R China
2.Chinese Peoples Liberat Army Gen Hosp, Affiliated Hosp 1, Dept Urol, Beijing 100048, Peoples R China
3.Peking Univ, Hosp 1, Androl Ctr, Beijing 100034, Peoples R China
4.Baoding First Hosp, Dept Urol, Baoding 071000, Peoples R China
5.Chinese Peoples Liberat Army Gen Hosp, Hainan Branch, Dept Urol, Sanya 572013, Hainan, Peoples R China
6.Acad Armoured Force Engn, Mil Dept, Beijing 100072, Peoples R China
7.Gen Hosp Chengdu Mil Command, Dept Urinary, Chengdu 610083, Sichuan, Peoples R China
8.Chinese Peoples Liberat Army Gen Hosp, Dept Urol, Beijing 100853, Peoples R China

Recommended Citation:
Li, Gang,Wu, Yuan-Yi,Fu, Wei-Jun,et al. Study of Clinical Practical Model of Urinary System Injury[J]. CHINESE MEDICAL JOURNAL,2015,128(7):928-932.
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