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Simultaneous determination of nine major flavonoids in Sophora flavescens by RP-LC
Ma, Xiao-Chi1,2; Xin, Xiu-Lan1,3; Liu, Ke-Xin2; Zhang, Bao-Jing2; Li, Feng-Yun2; Guo, De-An1
关键词Column Liquid Chromatography Quality Control Flavonoids Sophora Flavescens
刊名CHROMATOGRAPHIA
2008-09-01
DOI10.1365/s10337-008-0719-y
68期:5-6页:471-474
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemical Research Methods ; Chemistry, Analytical
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]PERFORMANCE LIQUID-CHROMATOGRAPHY ; CAPILLARY-ELECTROPHORESIS ; INHIBITORY FLAVONOIDS ; PRENYLATED FLAVONOIDS ; MEDICINAL-PLANTS ; CONSTITUENTS ; ROOTS ; AIT ; DAD ; ALKALOIDS
英文摘要

A liquid chromatographic method was applied to determine trifolirhizin, kushenol K, kushenol L, kushenol N, kushenol X, kurarinone, norkurarinone, isokurarinone and kushenol A in the roots of Sophora flavescens, namely Kushen in China. The samples were separated on a YMC-C(18) column (250 x 4.6 mm, 5 mu m) with a gradient of methanol and 0.3% aqueous acetic acid (v/v) at a flow rate of 0.8 mL min(-1) and detected at 295 nm. The complete separation was achieved within 45 min for the nine major flavonoids. All calibration curves expressed good linearity (r(2) > 0.999) within the test range. The recovery of this method was 92.3-106.9%. The assay was successfully applied to the quantification of nine flavonoids in 26 samples of Kushen. The results indicated that this developed LC assay could be readily utilized as a quality control method for the Chinese herb medicine Kushen.

语种英语
WOS记录号WOS:000259186700027
项目编号985-2- 063-112 ; 30701088
资助机构Changjiang Scholars and Innovative Team of the University ; National Natural Science Foundation of China ; PHR (IHLB)
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56035
专题北京大学药学院
北京大学药学院_天然药物与仿生药物国家重点实验室
作者单位1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
2.Dalian Med Univ, Sch Pharmaceut Sci, Dalian 116027, Peoples R China
3.Beijing Vocat Coll Elect Sci & Technol, Biotechnol Applicat Ctr, Beijing 100029, Peoples R China
推荐引用方式
GB/T 7714
Ma, Xiao-Chi,Xin, Xiu-Lan,Liu, Ke-Xin,et al. Simultaneous determination of nine major flavonoids in Sophora flavescens by RP-LC[J]. CHROMATOGRAPHIA,2008,68(5-6):471-474.
APA Ma, Xiao-Chi,Xin, Xiu-Lan,Liu, Ke-Xin,Zhang, Bao-Jing,Li, Feng-Yun,&Guo, De-An.(2008).Simultaneous determination of nine major flavonoids in Sophora flavescens by RP-LC.CHROMATOGRAPHIA,68(5-6),471-474.
MLA Ma, Xiao-Chi,et al."Simultaneous determination of nine major flavonoids in Sophora flavescens by RP-LC".CHROMATOGRAPHIA 68.5-6(2008):471-474.
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