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学科主题: 临床医学
题名:
Analysis of meiotic segregation patterns and interchromosomal effects in sperm from six males with Robertsonian translocations
作者: Chen, Yongjian; Huang, Jin; Liu, Ping; Qiao, Jie
关键词: fluorescence in-situ hybridization ; interchromosomal effects ; meiotic segregation ; Robertsonian translocation ; sperm
刊名: JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
发表日期: 2007-09-01
DOI: 10.1007/s10815-007-9137-6
卷: 24, 期:9, 页:406-411
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Genetics & Heredity ; Obstetrics & Gynecology ; Reproductive Biology
研究领域[WOS]: Genetics & Heredity ; Obstetrics & Gynecology ; Reproductive Biology
关键词[WOS]: INFERTILE MEN ; FISH ANALYSIS ; CARRIER ; SPERMATOZOA ; CHROMOSOMES ; NUCLEI ; ABNORMALITIES ; ASSOCIATION ; TRIVALENT ; PROBES
英文摘要:

Purpose To provide more genetic information about meiotic segregation behavior and the possibility of interchromosomal effects (ICE) in spermatozoa from carriers of Robertsonian (Rob) translocations.

Materials and methods Meiotic segregation behavior in spermatozoa from six carriers of Rob translocations, four t(13;14), one t(14;22) and one t(13;21), was investigated by dual fluorescence in-situ hybridization (FISH). Aneuploidy for chromosomes 18, X and Y was studied by triple FISH.

Results The rate of normal/balanced spermatozoa resulting from alternate segregation ranged from 78.14 to 86.88%. The frequency of unbalanced spermatozoa resulting from adjacent segregation varied between 11.70 and 19.53%. The higher frequencies of aneuploidy for sex chromosome were observed in three Rob translocation carriers. In addition, the increased rates of diploid were found in two t(13;14) carriers.

Conclusions Alternate segregation is dominant in the different types of Rob translocations. Some carriers may be at an increased risk for ICE.

语种: 英语
WOS记录号: WOS:000249791700005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56039
Appears in Collections:北京大学第三临床医学院_生殖医学中心_期刊论文

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作者单位: Peking Univ, Ctr Reprod Med, Hosp 3, Beijing 100083, Peoples R China

Recommended Citation:
Chen, Yongjian,Huang, Jin,Liu, Ping,et al. Analysis of meiotic segregation patterns and interchromosomal effects in sperm from six males with Robertsonian translocations[J]. JOURNAL OF ASSISTED REPRODUCTION AND GENETICS,2007,24(9):406-411.
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