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Analysis of meiotic segregation patterns and interchromosomal effects in sperm from six males with Robertsonian translocations
Chen, Yongjian; Huang, Jin; Liu, Ping; Qiao, Jie
关键词Fluorescence In-situ Hybridization Interchromosomal Effects Meiotic Segregation Robertsonian Translocation Sperm
刊名JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
2007-09-01
DOI10.1007/s10815-007-9137-6
24期:9页:406-411
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Genetics & Heredity ; Obstetrics & Gynecology ; Reproductive Biology
研究领域[WOS]Genetics & Heredity ; Obstetrics & Gynecology ; Reproductive Biology
关键词[WOS]INFERTILE MEN ; FISH ANALYSIS ; CARRIER ; SPERMATOZOA ; CHROMOSOMES ; NUCLEI ; ABNORMALITIES ; ASSOCIATION ; TRIVALENT ; PROBES
英文摘要

Purpose To provide more genetic information about meiotic segregation behavior and the possibility of interchromosomal effects (ICE) in spermatozoa from carriers of Robertsonian (Rob) translocations.

Materials and methods Meiotic segregation behavior in spermatozoa from six carriers of Rob translocations, four t(13;14), one t(14;22) and one t(13;21), was investigated by dual fluorescence in-situ hybridization (FISH). Aneuploidy for chromosomes 18, X and Y was studied by triple FISH.

Results The rate of normal/balanced spermatozoa resulting from alternate segregation ranged from 78.14 to 86.88%. The frequency of unbalanced spermatozoa resulting from adjacent segregation varied between 11.70 and 19.53%. The higher frequencies of aneuploidy for sex chromosome were observed in three Rob translocation carriers. In addition, the increased rates of diploid were found in two t(13;14) carriers.

Conclusions Alternate segregation is dominant in the different types of Rob translocations. Some carriers may be at an increased risk for ICE.

语种英语
WOS记录号WOS:000249791700005
引用统计
被引频次:19[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56039
专题北京大学第三临床医学院_生殖医学中心
作者单位Peking Univ, Ctr Reprod Med, Hosp 3, Beijing 100083, Peoples R China
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GB/T 7714
Chen, Yongjian,Huang, Jin,Liu, Ping,et al. Analysis of meiotic segregation patterns and interchromosomal effects in sperm from six males with Robertsonian translocations[J]. JOURNAL OF ASSISTED REPRODUCTION AND GENETICS,2007,24(9):406-411.
APA Chen, Yongjian,Huang, Jin,Liu, Ping,&Qiao, Jie.(2007).Analysis of meiotic segregation patterns and interchromosomal effects in sperm from six males with Robertsonian translocations.JOURNAL OF ASSISTED REPRODUCTION AND GENETICS,24(9),406-411.
MLA Chen, Yongjian,et al."Analysis of meiotic segregation patterns and interchromosomal effects in sperm from six males with Robertsonian translocations".JOURNAL OF ASSISTED REPRODUCTION AND GENETICS 24.9(2007):406-411.
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