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Ultrafine carbon black disturbs heart rate variability in mice
Jia, Xiaofeng; Hao, Yu; Guo, Xinbiao
关键词Particulate Matter Ultrafine Carbon Black Cardiac Autonomic Nervous System Heart Rate Variability Mice
刊名TOXICOLOGY LETTERS
2012-06-20
DOI10.1016/j.toxlet.2012.04.007
211期:3页:274-280
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Toxicology
资助者National Natural Science Foundation of China ; National High Technology Research and Development Program of China ; National Key Technologies R&amp ; D Program of China ; National Natural Science Foundation of China ; National High Technology Research and Development Program of China ; National Key Technologies R&amp ; D Program of China
研究领域[WOS]Toxicology
关键词[WOS]SPONTANEOUSLY HYPERTENSIVE-RATS ; CARDIAC OXIDATIVE STRESS ; AIR-POLLUTION ; PHYSIOPHARMACOLOGICAL INVESTIGATIONS ; CARDIOVASCULAR-DISEASE ; URETHANE ANESTHESIA ; APOE(-/-) MICE ; EXPOSURE ; PARTICLES ; SUITABILITY
英文摘要

Previous epidemiological and toxicological studies have reported the associations between ambient particulate matter (PM) exposure and changes in heart rate variability (HRV), a marker of cardiac autonomic nervous system (ANS) function. However, both the responsible components in PM and their mechanisms affecting HRV remain uncertain. We propose that carbon black (CB), one of the main components in PM, may affect HRV through mechanisms independent of cardio-pulmonary and systemic inflammation and/or injury. Male C57BL/6 mice were exposed by intra-tracheal instillation to ultrafine CB (once every two days for three times) at doses of 0, 0.05, 0.15 and 0.6 mg/kg. HRV indices, standard deviation of all normal R-R intervals (SDNN) and the square root of mean of sum of squares of differences between adjacent normal R-R intervals (RMSSD), showed significant decreases in 0.15 and 0.6 mg/kg CB exposed groups. Slight pulmonary inflammation and myocardial injury were only observed in 0.6 mg/kg CB exposed group. We conclude that CB can disturb cardiac ANS function in mice, indicated by the withdrawal of parasympathetic modulation, through mechanisms independent of apparent myocardial and pulmonary injury. (c) 2012 Elsevier Ireland Ltd. All rights reserved.

语种英语
所属项目编号81072267 ; 30571534 ; 2012AA062804 ; 2006BAI19B06
资助者National Natural Science Foundation of China ; National High Technology Research and Development Program of China ; National Key Technologies R&amp ; D Program of China ; National Natural Science Foundation of China ; National High Technology Research and Development Program of China ; National Key Technologies R&amp ; D Program of China
WOS记录号WOS:000305496800008
引用统计
被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56041
专题北京大学公共卫生学院
作者单位Peking Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth Sci, Beijing 100191, Peoples R China
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GB/T 7714
Jia, Xiaofeng,Hao, Yu,Guo, Xinbiao. Ultrafine carbon black disturbs heart rate variability in mice[J]. TOXICOLOGY LETTERS,2012,211(3):274-280.
APA Jia, Xiaofeng,Hao, Yu,&Guo, Xinbiao.(2012).Ultrafine carbon black disturbs heart rate variability in mice.TOXICOLOGY LETTERS,211(3),274-280.
MLA Jia, Xiaofeng,et al."Ultrafine carbon black disturbs heart rate variability in mice".TOXICOLOGY LETTERS 211.3(2012):274-280.
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