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学科主题: 公共卫生
题名:
Ultrafine carbon black disturbs heart rate variability in mice
作者: Jia, Xiaofeng; Hao, Yu; Guo, Xinbiao
关键词: Particulate matter ; Ultrafine carbon black ; Cardiac autonomic nervous system ; Heart rate variability ; Mice
刊名: TOXICOLOGY LETTERS
发表日期: 2012-06-20
DOI: 10.1016/j.toxlet.2012.04.007
卷: 211, 期:3, 页:274-280
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Toxicology
研究领域[WOS]: Toxicology
关键词[WOS]: SPONTANEOUSLY HYPERTENSIVE-RATS ; CARDIAC OXIDATIVE STRESS ; AIR-POLLUTION ; PHYSIOPHARMACOLOGICAL INVESTIGATIONS ; CARDIOVASCULAR-DISEASE ; URETHANE ANESTHESIA ; APOE(-/-) MICE ; EXPOSURE ; PARTICLES ; SUITABILITY
英文摘要:

Previous epidemiological and toxicological studies have reported the associations between ambient particulate matter (PM) exposure and changes in heart rate variability (HRV), a marker of cardiac autonomic nervous system (ANS) function. However, both the responsible components in PM and their mechanisms affecting HRV remain uncertain. We propose that carbon black (CB), one of the main components in PM, may affect HRV through mechanisms independent of cardio-pulmonary and systemic inflammation and/or injury. Male C57BL/6 mice were exposed by intra-tracheal instillation to ultrafine CB (once every two days for three times) at doses of 0, 0.05, 0.15 and 0.6 mg/kg. HRV indices, standard deviation of all normal R-R intervals (SDNN) and the square root of mean of sum of squares of differences between adjacent normal R-R intervals (RMSSD), showed significant decreases in 0.15 and 0.6 mg/kg CB exposed groups. Slight pulmonary inflammation and myocardial injury were only observed in 0.6 mg/kg CB exposed group. We conclude that CB can disturb cardiac ANS function in mice, indicated by the withdrawal of parasympathetic modulation, through mechanisms independent of apparent myocardial and pulmonary injury. (c) 2012 Elsevier Ireland Ltd. All rights reserved.

语种: 英语
所属项目编号: 81072267 ; 30571534 ; 2012AA062804 ; 2006BAI19B06
项目资助者: National Natural Science Foundation of China ; National High Technology Research and Development Program of China ; National Key Technologies R&amp ; D Program of China
WOS记录号: WOS:000305496800008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56041
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: Peking Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth Sci, Beijing 100191, Peoples R China

Recommended Citation:
Jia, Xiaofeng,Hao, Yu,Guo, Xinbiao. Ultrafine carbon black disturbs heart rate variability in mice[J]. TOXICOLOGY LETTERS,2012,211(3):274-280.
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