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学科主题: 公共卫生
题名:
Effect of cytotoxic T-lymphocyte-associated protein 4 on CD4(+)CD25(+) regulatory T cells in murine Schistosomiasis japonica
作者: Tang, Chun-Lian1; Lei, Jia-Hui2; Guan, Fei2; Li, Yong-Long2; Liu, Rong3; Grevelding, Christoph G.4; Jiang, Ming-Sen5; Dong, Hui-Fen5
关键词: Schistosoma japonicum ; CD4(+)CD25(+) Tregs ; CTLA-4 ; Cytokines ; Immune evasion
刊名: EXPERIMENTAL PARASITOLOGY
发表日期: 2014
DOI: 10.1016/j.exppara.2013.11.001
卷: 136, 页:74-78
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Parasitology
研究领域[WOS]: Parasitology
关键词[WOS]: TRYPANOSOMA-CRUZI INFECTION ; PROTECTIVE IMMUNITY ; GRANULOMA-FORMATION ; ANTIGEN-4 BLOCKADE ; IN-VIVO ; CTLA-4 ; MICE ; VACCINATION ; MECHANISMS ; TOLERANCE
英文摘要:

In a previous study we demonstrated that CD4(+)CD25(+) regulatory T cells (Tregs) contributed to the escape of Schistosoma japonicum (S. japonicum) from the host′s immune responses. In this paper, we studied the effect of cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) on CD4(+)CD25(+) Tregs in murine Schistosomiasis japonica and its corresponding role in the immune evasion of S. japonicum in mice. The results showed substantial reductions of worm burden and egg production in worm groups treated with anti-CD25 or anti-CTLA-4 monoclonal antibodies (mAb) compared to an infected but untreated control. The reduction effect was even enhanced in an experimental group co-treated with both mAbs. Compared to the control group, the percentage of CD4(+)CD25(+) Tregs was very much lower in the anti-CD25 mAb group as determined by FACS analyses and higher in the anti-CTLA-4 mAb group. ELISA analyses showed that both the anti-CTLA-4 mAb and the co-treated groups had higher levels of cytokines compared to the control group as well as larger egg granuloma sizes as determined by microscopical analyses of liver sections of infected mice. These results suggest that treatment with an anti-CTLA-4 mAb allows the host to clear S. japonicum, but at the cost of elevated pathological damage. The latter indicated a role of CTLA-4 in granuloma formation. Moreover, CD4(+)CD25(+) Tregs and CTLA-4 may exert synergistic effects during immune evasion processes by enhancing Th1-type immune response. (C) 2013 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000329952100011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56044
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Wuchang Hosp, Dept Clin Lab, Wuhan 430063, Peoples R China
2.Peking Univ, Sch Publ Hlth, Beijing 100191, Peoples R China
3.Univ Giessen, Inst Parasitol, D-35392 Giessen, Germany
4.Huazhong Univ Sci & Technol, Tongji Med Coll, Dept Parasitol, Wuhan 430030, Peoples R China
5.Wuhan Univ, Dept Parasitol, Coll Med, Wuhan 430071, Peoples R China

Recommended Citation:
Tang, Chun-Lian,Lei, Jia-Hui,Guan, Fei,et al. Effect of cytotoxic T-lymphocyte-associated protein 4 on CD4(+)CD25(+) regulatory T cells in murine Schistosomiasis japonica[J]. EXPERIMENTAL PARASITOLOGY,2014,136:74-78.
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