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Effect of cytotoxic T-lymphocyte-associated protein 4 on CD4(+)CD25(+) regulatory T cells in murine Schistosomiasis japonica
Tang, Chun-Lian1; Lei, Jia-Hui2; Guan, Fei2; Li, Yong-Long2; Liu, Rong3; Grevelding, Christoph G.4; Jiang, Ming-Sen5; Dong, Hui-Fen5
关键词Schistosoma Japonicum Cd4(+)Cd25(+) Tregs Ctla-4 Cytokines Immune Evasion
刊名EXPERIMENTAL PARASITOLOGY
2014
DOI10.1016/j.exppara.2013.11.001
136页:74-78
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Parasitology
研究领域[WOS]Parasitology
关键词[WOS]TRYPANOSOMA-CRUZI INFECTION ; PROTECTIVE IMMUNITY ; GRANULOMA-FORMATION ; ANTIGEN-4 BLOCKADE ; IN-VIVO ; CTLA-4 ; MICE ; VACCINATION ; MECHANISMS ; TOLERANCE
英文摘要

In a previous study we demonstrated that CD4(+)CD25(+) regulatory T cells (Tregs) contributed to the escape of Schistosoma japonicum (S. japonicum) from the host′s immune responses. In this paper, we studied the effect of cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) on CD4(+)CD25(+) Tregs in murine Schistosomiasis japonica and its corresponding role in the immune evasion of S. japonicum in mice. The results showed substantial reductions of worm burden and egg production in worm groups treated with anti-CD25 or anti-CTLA-4 monoclonal antibodies (mAb) compared to an infected but untreated control. The reduction effect was even enhanced in an experimental group co-treated with both mAbs. Compared to the control group, the percentage of CD4(+)CD25(+) Tregs was very much lower in the anti-CD25 mAb group as determined by FACS analyses and higher in the anti-CTLA-4 mAb group. ELISA analyses showed that both the anti-CTLA-4 mAb and the co-treated groups had higher levels of cytokines compared to the control group as well as larger egg granuloma sizes as determined by microscopical analyses of liver sections of infected mice. These results suggest that treatment with an anti-CTLA-4 mAb allows the host to clear S. japonicum, but at the cost of elevated pathological damage. The latter indicated a role of CTLA-4 in granuloma formation. Moreover, CD4(+)CD25(+) Tregs and CTLA-4 may exert synergistic effects during immune evasion processes by enhancing Th1-type immune response. (C) 2013 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000329952100011
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56044
专题北京大学公共卫生学院
作者单位1.Wuchang Hosp, Dept Clin Lab, Wuhan 430063, Peoples R China
2.Peking Univ, Sch Publ Hlth, Beijing 100191, Peoples R China
3.Univ Giessen, Inst Parasitol, D-35392 Giessen, Germany
4.Huazhong Univ Sci & Technol, Tongji Med Coll, Dept Parasitol, Wuhan 430030, Peoples R China
5.Wuhan Univ, Dept Parasitol, Coll Med, Wuhan 430071, Peoples R China
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GB/T 7714
Tang, Chun-Lian,Lei, Jia-Hui,Guan, Fei,et al. Effect of cytotoxic T-lymphocyte-associated protein 4 on CD4(+)CD25(+) regulatory T cells in murine Schistosomiasis japonica[J]. EXPERIMENTAL PARASITOLOGY,2014,136:74-78.
APA Tang, Chun-Lian.,Lei, Jia-Hui.,Guan, Fei.,Li, Yong-Long.,Liu, Rong.,...&Dong, Hui-Fen.(2014).Effect of cytotoxic T-lymphocyte-associated protein 4 on CD4(+)CD25(+) regulatory T cells in murine Schistosomiasis japonica.EXPERIMENTAL PARASITOLOGY,136,74-78.
MLA Tang, Chun-Lian,et al."Effect of cytotoxic T-lymphocyte-associated protein 4 on CD4(+)CD25(+) regulatory T cells in murine Schistosomiasis japonica".EXPERIMENTAL PARASITOLOGY 136(2014):74-78.
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