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学科主题: 临床医学
题名:
Modified Wu-Zi-Yan-Zong prescription, a traditional Chinese polyherbal formula, suppresses lipopolysaccharide-induced neuroinflammatory processes in rat astrocytes via NF-kappa B and JNK/p38 MAPK signaling pathways
作者: Zeng, Ke-Wu; Zhang, Tai; Fu, Hong; Liu, Geng-Xin; Wang, Xue-Mei
关键词: Neuroinflammation ; Modified Wu-Zi-Yan-Zong prescription ; Traditional Chinese medicine ; Astrocyte ; Lipopolysaccharide ; H PLC-analysis
刊名: PHYTOMEDICINE
发表日期: 2012-01-15
DOI: 10.1016/j.phymed.2011.08.003
卷: 19, 期:2, 页:122-129
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Plant Sciences ; Chemistry, Medicinal ; Integrative & Complementary Medicine ; Pharmacology & Pharmacy
研究领域[WOS]: Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine
关键词[WOS]: INHIBITION ; ACTIVATION ; NEURONS ; KINASE ; NO
英文摘要:

Neuroinflammation plays an important role in several neurodegenerative diseases. In this study, we investigated the anti-inflammatory properties of modified Wu-Zi-Yan-Zong prescription (MWP), a traditional Chinese polyherbal formula, in primary cultured rat astrocytes treated with lipopolysaccharide (LPS). The results showed that MWP significantly inhibited release of nitric oxide (NO) and prostaglandin E (PGE), as well as expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 in LPS-induced rat astrocytes. Mechanism study indicated that MWP significantly inhibited nuclear factor-kappa B (NF-kappa B) inflammatory signaling pathway through attenuating inhibitor of nuclear factor-kappa B (I kappa B) degradation and down-regulating I kappa B kinases (IKKs) phosphorylation level. Moreover, MWP also decreased c-Jun NH2-terminal kinase (JNK)/p38 mitogen-activated protein kinase (MAPK) phosphorylation, which play an important role in the induction of proinflammatory gene expressions. At last, MWP protected neurons from LPS-activated astrocytes in neuron-astrocyte co-culture system. Taken together, our results suggest that MWP may act to suppress neuroinflammatory response in LPS-stimulated rat astrocytes via NF-kappa B and JNK/p38 MAPK signaling cascades, and MWP may be a useful agent for prevention and treatment of neuroinflammatory disease. (C) 2011 Elsevier GmbH. All rights reserved.

语种: 英语
所属项目编号: 30973813 ; 81173369
项目资助者: National Natural Science Funds of China, China
WOS记录号: WOS:000300332800004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56048
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: Peking Univ, Hosp 1, Beijing 100034, Peoples R China

Recommended Citation:
Zeng, Ke-Wu,Zhang, Tai,Fu, Hong,et al. Modified Wu-Zi-Yan-Zong prescription, a traditional Chinese polyherbal formula, suppresses lipopolysaccharide-induced neuroinflammatory processes in rat astrocytes via NF-kappa B and JNK/p38 MAPK signaling pathways[J]. PHYTOMEDICINE,2012,19(2):122-129.
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