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学科主题: 临床医学
题名:
Investigation of ERCC1 and ERCC2 gene polymorphisms and response to chemotherapy and overall survival in osteosarcoma
作者: Zhang, Q.1; Lv, L. Y.1; Li, B. J.1; Zhang, J.1; Wei, F.2
关键词: ERCC1 ; ERCC2 ; Chemotherapy ; Overall survival ; Osteosarcoma ; Single nucleotide polymorphism
刊名: GENETICS AND MOLECULAR RESEARCH
发表日期: 2015
DOI: 10.4238/2015.September.22.17
卷: 14, 期:3, 页:11235-11241
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Genetics & Heredity
研究领域[WOS]: Biochemistry & Molecular Biology ; Genetics & Heredity
关键词[WOS]: CELL LUNG-CANCER ; BONE-TUMOR ; PROGNOSIS ; EPIDEMIOLOGY
英文摘要:

We assessed the role of single nucleotide polymorphisms (SNPs) in ERCC1 and ERCC2 genes in the clinical outcomes for osteosarcoma patients receiving cisplatin-based treatment. A perspective study was conducted on 260 patients with osteosarcoma during 2010 and 2011. A polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) assay was used to assess the ERCC1 rs11615 and rs3212986, and the ERCC2 rs1799793 and rs13181 gene polymorphisms. After adjustment for clinical variables, we found that the CC genotype of ERCC1 rs11615 was significantly associated with better response to chemotherapy (OR = 2.87, 95% CI = 1.24-6.97). Our study found that those carrying the CC genotype of ERCC1 rs11615 had a longer overall survival compared with the TT genotype, and the OR (95% CI) was 0.35 (0.12-0.92). In conclusion, our results suggest that the ERCC1 rs11615 polymorphism might influence the response to cisplatin-based chemotherapy and affect the clinical outcome for osteosarcoma patients.

语种: 英语
WOS记录号: WOS:000362421700084
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56050
Appears in Collections:北京大学第三临床医学院_骨科_期刊论文

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作者单位: 1.Second Peoples Hosp Liaocheng, Dept Orthopaed, Shandong, Peoples R China
2.Peking Univ, Hosp 3, Dept Orthopaed, Beijing 100871, Peoples R China

Recommended Citation:
Zhang, Q.,Lv, L. Y.,Li, B. J.,et al. Investigation of ERCC1 and ERCC2 gene polymorphisms and response to chemotherapy and overall survival in osteosarcoma[J]. GENETICS AND MOLECULAR RESEARCH,2015,14(3):11235-11241.
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