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学科主题临床医学
Investigation of ERCC1 and ERCC2 gene polymorphisms and response to chemotherapy and overall survival in osteosarcoma
Zhang, Q.1; Lv, L. Y.1; Li, B. J.1; Zhang, J.1; Wei, F.2
关键词Ercc1 Ercc2 Chemotherapy Overall Survival Osteosarcoma Single Nucleotide Polymorphism
刊名GENETICS AND MOLECULAR RESEARCH
2015
DOI10.4238/2015.September.22.17
14期:3页:11235-11241
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Genetics & Heredity
研究领域[WOS]Biochemistry & Molecular Biology ; Genetics & Heredity
关键词[WOS]CELL LUNG-CANCER ; BONE-TUMOR ; PROGNOSIS ; EPIDEMIOLOGY
英文摘要

We assessed the role of single nucleotide polymorphisms (SNPs) in ERCC1 and ERCC2 genes in the clinical outcomes for osteosarcoma patients receiving cisplatin-based treatment. A perspective study was conducted on 260 patients with osteosarcoma during 2010 and 2011. A polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) assay was used to assess the ERCC1 rs11615 and rs3212986, and the ERCC2 rs1799793 and rs13181 gene polymorphisms. After adjustment for clinical variables, we found that the CC genotype of ERCC1 rs11615 was significantly associated with better response to chemotherapy (OR = 2.87, 95% CI = 1.24-6.97). Our study found that those carrying the CC genotype of ERCC1 rs11615 had a longer overall survival compared with the TT genotype, and the OR (95% CI) was 0.35 (0.12-0.92). In conclusion, our results suggest that the ERCC1 rs11615 polymorphism might influence the response to cisplatin-based chemotherapy and affect the clinical outcome for osteosarcoma patients.

语种英语
WOS记录号WOS:000362421700084
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56050
专题北京大学第三临床医学院_骨科
作者单位1.Second Peoples Hosp Liaocheng, Dept Orthopaed, Shandong, Peoples R China
2.Peking Univ, Hosp 3, Dept Orthopaed, Beijing 100871, Peoples R China
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GB/T 7714
Zhang, Q.,Lv, L. Y.,Li, B. J.,et al. Investigation of ERCC1 and ERCC2 gene polymorphisms and response to chemotherapy and overall survival in osteosarcoma[J]. GENETICS AND MOLECULAR RESEARCH,2015,14(3):11235-11241.
APA Zhang, Q.,Lv, L. Y.,Li, B. J.,Zhang, J.,&Wei, F..(2015).Investigation of ERCC1 and ERCC2 gene polymorphisms and response to chemotherapy and overall survival in osteosarcoma.GENETICS AND MOLECULAR RESEARCH,14(3),11235-11241.
MLA Zhang, Q.,et al."Investigation of ERCC1 and ERCC2 gene polymorphisms and response to chemotherapy and overall survival in osteosarcoma".GENETICS AND MOLECULAR RESEARCH 14.3(2015):11235-11241.
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