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学科主题: 药学
题名:
Honokiol inhibits the inflammatory reaction during cerebral ischemia reperfusion by suppressing NF-kappa B activation and cytokine production of glial cells
作者: Zhang, Peng1; Liu, Xiaoyan1; Zhu, Yuanjun1; Chen, Shizhong2; Zhou, Demin3; Wang, Yinye1
关键词: Honokiol ; Anti-inflammation ; Ischemia-reperfusion ; Primary glial cell ; Nuclear factor-kappa B ; Inflammatory factor
刊名: NEUROSCIENCE LETTERS
发表日期: 2013-02-08
DOI: 10.1016/j.neulet.2012.11.052
卷: 534, 页:123-127
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: RESPONSES ; SYSTEM
英文摘要:

This study was designed to investigate the effects of honokiol, a neuroprotective agent, on cerebral edema in cerebral ischemia reperfusion (IR) mice and its mechanism of anti-inflammation. Honokiol (0.7-70 mu g/kg) significantly reduced brain water contents and decreased the exudation of Evans blue dye from brain capillaries in cerebral IR mice. Honokiol (0.1-10 mu M) significantly reduced the p65 subunit level of NF-kappa B in the nucleus of primary culture-microglia. It (0.01-10 mu M) evidently reduced nitric oxide (NO) level in the microglia culture medium and in the microglia and astrocytes coculture medium. Honokiol (0.01-10 mu M) significantly decreased the level of TNF-alpha in the microglia medium or coculture cell medium. Honokiol (10 mu M) decreased the level of Regulated upon Activation Normal T-cell Expressed and Secreted (RANTES/CCL5) protein in medium of microglia or astrocytes. In conclusion, Honokiol has a potent anti-inflammatory effect in cerebral ischemia-reperfusion mice and this effect might be attributed to its inhibition ability on the NF-kappa B activation, consequently blocking the production of inflammatory factors including: NO, tumor necrosis factor-alpha (TNF-alpha) and RANTES/CCL5 in glial cells. These results provide evidence for the anti-inflammatory effect of honokiol for the potential treatment of ischemic (C) 2012 Elsevier Ireland Ltd. All rights reserved.

语种: 英语
所属项目编号: 2009zx09102-146 ; 61071002
项目资助者: Chinese National Technology Graveness Special Purpose Fund ; Natural Science Foundation of China
WOS记录号: WOS:000320088300023
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56053
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, Dept Mol & Cellular Pharmacol, Beijing 100191, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Dept Nat Med, Beijing 100191, Peoples R China
3.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

Recommended Citation:
Zhang, Peng,Liu, Xiaoyan,Zhu, Yuanjun,et al. Honokiol inhibits the inflammatory reaction during cerebral ischemia reperfusion by suppressing NF-kappa B activation and cytokine production of glial cells[J]. NEUROSCIENCE LETTERS,2013,534:123-127.
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