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学科主题临床医学
Tumor suppressive microRNA-200a inhibits renal cell carcinoma development by directly targeting TGFB2
Lu, Ruijing1,2; Ji, Ziliang3; Li, Xiaoqing1; Qin, Jie1; Cui, Guanghui1; Chen, Jing1; Zhai, Qingna1,2; Zhao, Chunjuan1; Zhang, Wei4; Yu, Zhendong1
关键词Mir-200a Tumor Suppressor Tgfb2 Renal Cell Carcinoma
刊名TUMOR BIOLOGY
2015-09-01
DOI10.1007/s13277-015-3355-9
36期:9页:6691-6700
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]EPITHELIAL-MESENCHYMAL TRANSITION ; MIR-200 FAMILY ; MOLECULAR TARGETS ; REPRESSORS ZEB1 ; CANCER-CELLS ; EXPRESSION ; MIGRATION ; GROWTH ; PROGRESSION ; METASTASIS
英文摘要

A large body of evidence indicates that microRNAs play a critical role in tumor initiation and progression by negatively regulating oncogenes or tumor suppressor genes. Here, we report that the expression of miR-200a was notably downregulated in 45 renal cell carcinoma (RCC) samples. Restoration of miR-200a suppressed cell proliferation, migration, and invasion in two RCC cell lines. Furthermore, we used an epithelial-to-mesenchymal transition PCR array to explore the putative target genes of miR-200a. By performing quantitative real-time PCR, ELISA, and luciferase reporter assays, transforming growth factor beta2 (TGFB2) was validated as a direct target gene of miR-200a. Moreover, siRNA-mediated knockdown of TGFB2 partially phenocopied the effect of miR-200a overexpression. These results suggest that miR-200a suppresses RCC development via directly targeting TGFB2, indicating that miR-200a may present a novel target for diagnostic and therapeutic strategies in RCC.

语种英语
WOS记录号WOS:000365033100014
项目编号JCYJ20140415162543037 ; 201401049
资助机构Science and Technology Planning Project of Shenzhen in China ; Health and Family Planning Scientific Research Project of Shenzhen in China
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56055
专题北京大学深圳医院_中心实验室
北京大学第一临床医学院_小儿眼科
作者单位1.Peking Univ, Shenzhen Hosp, Cent Lab, Shenzhen 518036, Peoples R China
2.Baoan Dist Shenzhen Matern & Child Hlth Hosp, Clin Lab, Shenzhen 518133, Peoples R China
3.Longgang Dist Peoples Hosp Shenzhen, Dept Urol, Shenzhen 518172, Peoples R China
4.Hong Kong Univ Sci & Technol, Shenzhen Peking Univ, Biomed Res Inst, Shenzhen 518036, Peoples R China
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GB/T 7714
Lu, Ruijing,Ji, Ziliang,Li, Xiaoqing,et al. Tumor suppressive microRNA-200a inhibits renal cell carcinoma development by directly targeting TGFB2[J]. TUMOR BIOLOGY,2015,36(9):6691-6700.
APA Lu, Ruijing.,Ji, Ziliang.,Li, Xiaoqing.,Qin, Jie.,Cui, Guanghui.,...&Yu, Zhendong.(2015).Tumor suppressive microRNA-200a inhibits renal cell carcinoma development by directly targeting TGFB2.TUMOR BIOLOGY,36(9),6691-6700.
MLA Lu, Ruijing,et al."Tumor suppressive microRNA-200a inhibits renal cell carcinoma development by directly targeting TGFB2".TUMOR BIOLOGY 36.9(2015):6691-6700.
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