北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 基础医学院  > 期刊论文
学科主题: 基础医学
题名:
Serum Acylated Ghrelin Concentrations in Response to Short-Term Overfeeding in Normal Weight, Overweight, and Obese Men
作者: Wadden, Danny1; Cahill, Farrell1; Amini, Peyvand1; Randell, Edward2; Vasdev, Sudesh1; Yi, Yanqing1; Zhang, Weizhen3; Sun, Guang1
刊名: PLOS ONE
发表日期: 2012-09-27
DOI: 10.1371/journal.pone.0045748
卷: 7, 期:9
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: PRADER-WILLI-SYNDROME ; INCREASES FOOD-INTAKE ; PLASMA GHRELIN ; INSULIN-RESISTANCE ; CIRCULATING GHRELIN ; ENERGY-BALANCE ; HEALTHY-MEN ; BODY-FAT ; HUMANS ; RELEASE
英文摘要:

Background: Ghrelin, an orexigenic gut hormone secreted primarily from the stomach, is involved in energy homeostasis. However, little data is available regarding its response to energy surplus and the development of human obesity.

Objective: The present study investigated the response of circulating acylated ghrelin to a 7-day positive energy challenge.

Design: A total of 68 healthy young men were overfed 70% more calories than required, for 1-week. Subjects were classified based on percent body fat (measured by dual-energy X-ray absorptiometry) as normal weight, overweight, and obese. Serum acylated ghrelin concentration was measured before and after the positive energy challenge. Additionally, the relationship between acylated ghrelin and obesity-related phenotypes including weight, body mass index, percent body fat, cholesterol, HDL-c, LDL-c, glucose, insulin and homeostasis model assessment of insulin resistance and beta-cell function at baseline and change due to overfeeding, were assessed.

Results: Contrary to our expectations, serum acylated ghrelin was significantly increased in response to overfeeding and the increase was independent of obesity status. There was no significant difference in fasting acylated ghrelin between normal weight, overweight, and obese men at baseline. Acylated ghrelin was negatively correlated with weight and BMI for normal weight and with BMI in overweight men. Also ghrelin was correlated with change in weight and BMI in overweight (negative relationship) and obese (positive relationship) groups.

Conclusion: Our results showed that circulating acylated ghrelin was increased after a 7-day positive energy challenge regardless of adiposity status. However, acylated ghrelin was correlated with change in weight and BMI in opposing directions, in overweight and obese subjects respectively, thus dependent on obesity status.

语种: 英语
项目资助者: Canadian Institutes for Health Research (CIHR) ; Canada Foundation for Innovation (CFI)
WOS记录号: WOS:000309517500040
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56059
Appears in Collections:基础医学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Mem Univ Newfoundland, Fac Med, Div Med, St John, NF, Canada
2.Mem Univ Newfoundland, Discipline Lab Med, St John, NF, Canada
3.Peking Univ, Dept Physiol & Pathophysiol, Sch Basic Med Sci, Beijing 100871, Peoples R China

Recommended Citation:
Wadden, Danny,Cahill, Farrell,Amini, Peyvand,et al. Serum Acylated Ghrelin Concentrations in Response to Short-Term Overfeeding in Normal Weight, Overweight, and Obese Men[J]. PLOS ONE,2012,7(9).
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Wadden, Danny]'s Articles
[Cahill, Farrell]'s Articles
[Amini, Peyvand]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Wadden, Danny]‘s Articles
[Cahill, Farrell]‘s Articles
[Amini, Peyvand]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace