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Serum Acylated Ghrelin Concentrations in Response to Short-Term Overfeeding in Normal Weight, Overweight, and Obese Men
Wadden, Danny1; Cahill, Farrell1; Amini, Peyvand1; Randell, Edward2; Vasdev, Sudesh1; Yi, Yanqing1; Zhang, Weizhen3; Sun, Guang1
刊名PLOS ONE
2012-09-27
DOI10.1371/journal.pone.0045748
7期:9
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]PRADER-WILLI-SYNDROME ; INCREASES FOOD-INTAKE ; PLASMA GHRELIN ; INSULIN-RESISTANCE ; CIRCULATING GHRELIN ; ENERGY-BALANCE ; HEALTHY-MEN ; BODY-FAT ; HUMANS ; RELEASE
英文摘要

Background: Ghrelin, an orexigenic gut hormone secreted primarily from the stomach, is involved in energy homeostasis. However, little data is available regarding its response to energy surplus and the development of human obesity.

Objective: The present study investigated the response of circulating acylated ghrelin to a 7-day positive energy challenge.

Design: A total of 68 healthy young men were overfed 70% more calories than required, for 1-week. Subjects were classified based on percent body fat (measured by dual-energy X-ray absorptiometry) as normal weight, overweight, and obese. Serum acylated ghrelin concentration was measured before and after the positive energy challenge. Additionally, the relationship between acylated ghrelin and obesity-related phenotypes including weight, body mass index, percent body fat, cholesterol, HDL-c, LDL-c, glucose, insulin and homeostasis model assessment of insulin resistance and beta-cell function at baseline and change due to overfeeding, were assessed.

Results: Contrary to our expectations, serum acylated ghrelin was significantly increased in response to overfeeding and the increase was independent of obesity status. There was no significant difference in fasting acylated ghrelin between normal weight, overweight, and obese men at baseline. Acylated ghrelin was negatively correlated with weight and BMI for normal weight and with BMI in overweight men. Also ghrelin was correlated with change in weight and BMI in overweight (negative relationship) and obese (positive relationship) groups.

Conclusion: Our results showed that circulating acylated ghrelin was increased after a 7-day positive energy challenge regardless of adiposity status. However, acylated ghrelin was correlated with change in weight and BMI in opposing directions, in overweight and obese subjects respectively, thus dependent on obesity status.

语种英语
WOS记录号WOS:000309517500040
资助机构Canadian Institutes for Health Research (CIHR) ; Canada Foundation for Innovation (CFI)
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56059
专题北京大学基础医学院
作者单位1.Mem Univ Newfoundland, Fac Med, Div Med, St John, NF, Canada
2.Mem Univ Newfoundland, Discipline Lab Med, St John, NF, Canada
3.Peking Univ, Dept Physiol & Pathophysiol, Sch Basic Med Sci, Beijing 100871, Peoples R China
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GB/T 7714
Wadden, Danny,Cahill, Farrell,Amini, Peyvand,et al. Serum Acylated Ghrelin Concentrations in Response to Short-Term Overfeeding in Normal Weight, Overweight, and Obese Men[J]. PLOS ONE,2012,7(9).
APA Wadden, Danny.,Cahill, Farrell.,Amini, Peyvand.,Randell, Edward.,Vasdev, Sudesh.,...&Sun, Guang.(2012).Serum Acylated Ghrelin Concentrations in Response to Short-Term Overfeeding in Normal Weight, Overweight, and Obese Men.PLOS ONE,7(9).
MLA Wadden, Danny,et al."Serum Acylated Ghrelin Concentrations in Response to Short-Term Overfeeding in Normal Weight, Overweight, and Obese Men".PLOS ONE 7.9(2012).
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