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学科主题: 临床医学
题名:
New Species of Madurella, Causative Agents of Black-Grain Mycetoma
作者: de Hoog, G. Sybren2,3,4,5; van Diepeningen, Anne D.2; Mahgoub, El-Sheikh6; van de Sande, Wendy W. J.1
刊名: JOURNAL OF CLINICAL MICROBIOLOGY
发表日期: 2012-03-01
DOI: 10.1128/JCM.05477-11
卷: 50, 期:3, 页:988-994
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Microbiology
研究领域[WOS]: Microbiology
关键词[WOS]: IN-VITRO SUSCEPTIBILITIES ; MODIFIED NCCLS METHOD ; HYDROXIDE XTT ASSAY ; PSEUDOMYCETOMATIS ; IDENTIFICATION ; EUMYCETOMA
英文摘要:

A new species of nonsporulating fungus, isolated in a case of black-grain mycetoma in Sudan, is described as Madurella fahalii. The species is characterized by phenotypic and molecular criteria. Multigene phylogenies based on the ribosomal DNA (rDNA) internal transcribed spacer (ITS), the partial beta-tubulin gene (BT2), and the RNA polymerase II subunit 2 gene (RPB2) indicate that M. fahalii is closely related to Madurella mycetomatis and M. pseudomycetomatis; the latter name is validated according to the rules of botanical nomenclature. Madurella ikedae was found to be synonymous with M. mycetomatis. An isolate from Indonesia was found to be different from all known species based on multilocus analysis and is described as Madurella tropicana. Madurella is nested within the order Sordariales, with Chaetomium as its nearest neighbor. Madurella fahalii has a relatively low optimum growth temperature (30 degrees C) and is less susceptible to the azoles than other Madurella species, with voriconazole and posaconazole MICs of 1 mu g/ml, a ketoconazole MIC of 2 mu g/ml, and an itraconazole MIC of > 16 mu g/ml. Since eumycetoma is still treated only with azoles, correct species identification is important for the optimal choice of antifungal therapy.

语种: 英语
所属项目编号: 916.11.178
项目资助者: Netherlands Organization for Scientific Research (NWO, VENI)
WOS记录号: WOS:000300997800064
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56060
Appears in Collections:北京大学第一临床医学院_皮肤性病科_期刊论文

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作者单位: 1.Univ Khartoum, Mycetoma Res Ctr, Khartoum, Sudan
2.Cent Bur Schimmelcultures KNAW Fungal Biodivers C, Utrecht, Netherlands
3.Erasmus MC, Dept Med Microbiol & Infect Dis, Rotterdam, Netherlands
4.Univ Amsterdam, Inst Biodivers & Ecosyst Dynam, Amsterdam, Netherlands
5.Peking Univ, Hlth Sci Ctr, Res Ctr Med Mycol, Beijing 100871, Peoples R China
6.Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Guangzhou 510275, Guangdong, Peoples R China

Recommended Citation:
de Hoog, G. Sybren,van Diepeningen, Anne D.,Mahgoub, El-Sheikh,et al. New Species of Madurella, Causative Agents of Black-Grain Mycetoma[J]. JOURNAL OF CLINICAL MICROBIOLOGY,2012,50(3):988-994.
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