IR@PKUHSC  > 北京大学第一临床医学院  > 皮肤性病科
学科主题临床医学
New Species of Madurella, Causative Agents of Black-Grain Mycetoma
de Hoog, G. Sybren2,3,4,5; van Diepeningen, Anne D.2; Mahgoub, El-Sheikh6; van de Sande, Wendy W. J.1
刊名JOURNAL OF CLINICAL MICROBIOLOGY
2012-03-01
DOI10.1128/JCM.05477-11
50期:3页:988-994
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Microbiology
资助者Netherlands Organization for Scientific Research (NWO, VENI) ; Netherlands Organization for Scientific Research (NWO, VENI)
研究领域[WOS]Microbiology
关键词[WOS]IN-VITRO SUSCEPTIBILITIES ; MODIFIED NCCLS METHOD ; HYDROXIDE XTT ASSAY ; PSEUDOMYCETOMATIS ; IDENTIFICATION ; EUMYCETOMA
英文摘要

A new species of nonsporulating fungus, isolated in a case of black-grain mycetoma in Sudan, is described as Madurella fahalii. The species is characterized by phenotypic and molecular criteria. Multigene phylogenies based on the ribosomal DNA (rDNA) internal transcribed spacer (ITS), the partial beta-tubulin gene (BT2), and the RNA polymerase II subunit 2 gene (RPB2) indicate that M. fahalii is closely related to Madurella mycetomatis and M. pseudomycetomatis; the latter name is validated according to the rules of botanical nomenclature. Madurella ikedae was found to be synonymous with M. mycetomatis. An isolate from Indonesia was found to be different from all known species based on multilocus analysis and is described as Madurella tropicana. Madurella is nested within the order Sordariales, with Chaetomium as its nearest neighbor. Madurella fahalii has a relatively low optimum growth temperature (30 degrees C) and is less susceptible to the azoles than other Madurella species, with voriconazole and posaconazole MICs of 1 mu g/ml, a ketoconazole MIC of 2 mu g/ml, and an itraconazole MIC of > 16 mu g/ml. Since eumycetoma is still treated only with azoles, correct species identification is important for the optimal choice of antifungal therapy.

语种英语
所属项目编号916.11.178
资助者Netherlands Organization for Scientific Research (NWO, VENI) ; Netherlands Organization for Scientific Research (NWO, VENI)
WOS记录号WOS:000300997800064
引用统计
被引频次:31[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56060
专题北京大学第一临床医学院_皮肤性病科
作者单位1.Univ Khartoum, Mycetoma Res Ctr, Khartoum, Sudan
2.Cent Bur Schimmelcultures KNAW Fungal Biodivers C, Utrecht, Netherlands
3.Erasmus MC, Dept Med Microbiol & Infect Dis, Rotterdam, Netherlands
4.Univ Amsterdam, Inst Biodivers & Ecosyst Dynam, Amsterdam, Netherlands
5.Peking Univ, Hlth Sci Ctr, Res Ctr Med Mycol, Beijing 100871, Peoples R China
6.Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Guangzhou 510275, Guangdong, Peoples R China
推荐引用方式
GB/T 7714
de Hoog, G. Sybren,van Diepeningen, Anne D.,Mahgoub, El-Sheikh,et al. New Species of Madurella, Causative Agents of Black-Grain Mycetoma[J]. JOURNAL OF CLINICAL MICROBIOLOGY,2012,50(3):988-994.
APA de Hoog, G. Sybren,van Diepeningen, Anne D.,Mahgoub, El-Sheikh,&van de Sande, Wendy W. J..(2012).New Species of Madurella, Causative Agents of Black-Grain Mycetoma.JOURNAL OF CLINICAL MICROBIOLOGY,50(3),988-994.
MLA de Hoog, G. Sybren,et al."New Species of Madurella, Causative Agents of Black-Grain Mycetoma".JOURNAL OF CLINICAL MICROBIOLOGY 50.3(2012):988-994.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[de Hoog, G. Sybren]的文章
[van Diepeningen, Anne D.]的文章
[Mahgoub, El-Sheikh]的文章
百度学术
百度学术中相似的文章
[de Hoog, G. Sybren]的文章
[van Diepeningen, Anne D.]的文章
[Mahgoub, El-Sheikh]的文章
必应学术
必应学术中相似的文章
[de Hoog, G. Sybren]的文章
[van Diepeningen, Anne D.]的文章
[Mahgoub, El-Sheikh]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。