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学科主题: 口腔医学
题名:
Nuclear factor I-C expression pattern in developing teeth and its important role in odontogenic differentiation of human molar stem cells from the apical papilla
作者: Gao, Shuo; Zhao, Yu-Ming; Ge, Li-Hong
关键词: dental root development ; hSCAPs ; human ; NFIC ; odontogenic differentiation
刊名: EUROPEAN JOURNAL OF ORAL SCIENCES
发表日期: 2014-12-01
DOI: 10.1111/eos.12151
卷: 122, 期:6, 页:382-390
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Dentistry, Oral Surgery & Medicine
研究领域[WOS]: Dentistry, Oral Surgery & Medicine
关键词[WOS]: TRANSFORMING GROWTH-FACTOR-BETA-1 ; DENTIN SIALOPHOSPHOPROTEIN ; TRANSCRIPTION ; MICE ; COMPLEX ; ROOT ; ODONTOBLASTS ; DISRUPTION ; PROTEINS ; SKELETAL
英文摘要:

Nuclear factor I-C (NFIC) has an important role in the development of murine dental roots, but its role in human root formation is unreported. We thus elucidated the regulatory role of NFIC in the differentiation of human stem cells from the apical papilla (hSCAPs). The first step for this was to determine the expression of NFIC in human teeth, and it was found that NFIC expression was restricted to the odontoblasts and preodontoblasts of the developing molars of humans and mice. NFIC was found to be expressed in odontoblast-like cells after the subcutaneous transplantation of hSCAPs. NFIC expression was concomitant with dentin sialophosphoprotein (DSPP) in the mineralization of hSCAPs. NFIC knockdown in hSCAPs significantly inhibited expression of DSPP and promoted that of dentin matrix protein 1 (DMP1), meanwhile upregulated the expression of TGF-1 and downregulated SMAD3 and SMAD4. NFIC expression was significantly upregulated after TGF-1 treatment in hSCAPs. NFIC knockdown prolonged G1 phase of the cell cycle, but had no effect on cell proliferation and migration. These results suggest that NFIC is involved in the development of human root dentin and the regulation of odontoblastic differentiation of hSCAPs. NFIC may participate in the DMP1-DSPP signaling pathway and comprises a complex signaling cycle with TGF-1.

语种: 英语
所属项目编号: 81170928 ; 81141011
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000344785300003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56064
Appears in Collections:北京大学口腔医学院_儿童口腔科_期刊论文

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作者单位: Peking Univ, Hlth Sci Ctr, Sch & Hosp Stomatol, Dept Pediat Dent, Beijing 100081, Peoples R China

Recommended Citation:
Gao, Shuo,Zhao, Yu-Ming,Ge, Li-Hong. Nuclear factor I-C expression pattern in developing teeth and its important role in odontogenic differentiation of human molar stem cells from the apical papilla[J]. EUROPEAN JOURNAL OF ORAL SCIENCES,2014,122(6):382-390.
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