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In vitro synthesis of bioactive hydroxyapatite using sodium hyaluronate as a template
Li, Qiuhong1; Li, Ming1; Zhu, Peizhi1,3; Wei, Shicheng1,2
刊名JOURNAL OF MATERIALS CHEMISTRY
2012
DOI10.1039/c2jm33624c
22期:38页:20257-20265
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Physical ; Materials Science, Multidisciplinary
资助者State Key Development Program for Basic Research of China ; Fundamental Research Funds for the Central Universities ; Peking University ; State Key Development Program for Basic Research of China ; Fundamental Research Funds for the Central Universities ; Peking University
研究领域[WOS]Chemistry ; Materials Science
关键词[WOS]SOLID-STATE NMR ; CALCIUM PHOSPHATES ; NANOCRYSTALLINE HYDROXYAPATITE ; BIOMIMETIC MINERALIZATION ; OCTACALCIUM PHOSPHATE ; APATITE FORMATION ; BONE ; ACID ; BIOMINERALIZATION ; CARBONATE
英文摘要

Being a biocompatible and bioactive material, hyaluronic acid has great potential as a template to regulate the mineralization of hydroxyapatite (HA) nanocrystals in vitro. Our present study investigates the effects of sodium hyaluronate (SH) concentrations and initial pH values on the chemical composition, morphology and biological properties of hydroxyapatite (HA) crystals prepared by the wet chemical approach. All purified products were studied by Fourier transform infrared (FTIR) spectroscopy, X-ray diffractometry (XRD), X-ray photo-electronic spectroscopy (XPS), and transmission electron microscopy (TEM). This is the first time that bioactive carbonated apatites were synthesized using SH as a template. Biocompatibility of such apatites was gauged by cell vitality and alkaline phosphatase activity of MG-63 cells. The results suggested that carbonated apatites synthesized in the presence of SH were more favorable to the proliferation and differentiation of MG-63 cells compared to conventional apatites. In our study, we also found that SH temporarily stabilizes amorphous calcium phosphate (ACP) at the early stage of crystallization. The results imply that the initial pH value and the concentration of SH play a key role in affecting calcium vacancies, carbonate content and morphology of apatite crystals, as well as their effects on the proliferation and osteogenic differentiation of MG-63 cells. These synthesized carbonate-containing apatites are potentially attractive candidates for tissue engineering applications.

语种英语
所属项目编号2007CB936103
资助者State Key Development Program for Basic Research of China ; Fundamental Research Funds for the Central Universities ; Peking University ; State Key Development Program for Basic Research of China ; Fundamental Research Funds for the Central Universities ; Peking University
WOS记录号WOS:000308658600025
引用统计
被引频次:21[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56065
专题北京大学口腔医学院
作者单位1.Peking Univ, Ctr Biomed Mat & Tissue Engn, Acad Adv Interdisciplinary Studies, Beijing 100871, Peoples R China
2.Peking Univ, Sch Stomatol, Lab Interdisciplinary Studies, Dept Oral & Maxillofacial Surg, Beijing 100081, Peoples R China
3.Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA
推荐引用方式
GB/T 7714
Li, Qiuhong,Li, Ming,Zhu, Peizhi,et al. In vitro synthesis of bioactive hydroxyapatite using sodium hyaluronate as a template[J]. JOURNAL OF MATERIALS CHEMISTRY,2012,22(38):20257-20265.
APA Li, Qiuhong,Li, Ming,Zhu, Peizhi,&Wei, Shicheng.(2012).In vitro synthesis of bioactive hydroxyapatite using sodium hyaluronate as a template.JOURNAL OF MATERIALS CHEMISTRY,22(38),20257-20265.
MLA Li, Qiuhong,et al."In vitro synthesis of bioactive hydroxyapatite using sodium hyaluronate as a template".JOURNAL OF MATERIALS CHEMISTRY 22.38(2012):20257-20265.
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