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IR@PKUHSC  > 北京大学第三临床医学院  > 消化科  > 期刊论文
学科主题: 临床医学
题名:
Russell body gastritis/duodenitis: A case series and description of immunoglobulin light chain restriction
作者: Zhang, Hejun; Jin, Zhu; Cui, Rongli
刊名: CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY
发表日期: 2014-10-01
DOI: 10.1016/j.clinre.2014.05.008
卷: 38, 期:5, 页:E89-E97
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
关键词[WOS]: HELICOBACTER-PYLORI INFECTION ; GASTRITIS CASE-REPORT ; HIV-POSITIVE PATIENT ; OF-THE-LITERATURE ; PLASMA-CELLS ; BODIES ; MONOCLONALITY ; STOMACH ; MUCOSA ; TUMOR
英文摘要:

Russell body esophago-gastro-duodenitis is an unusual form of chronic inflammation, with only 22 cases being reported in PubMed. However, the prevalence and clinical significance remain unknown. This report describes the clinico-pathological characteristics of nine cases of Russell body gastritis (RBG) and one case of Russell body duodentitis (RBD), with nonspecific endoscopic appearance. The Mott cells (plasma cells with Russell bodies) showed kappa light chain restriction in eight gastritis cases and lambda light chain restriction in the duodentitis case, and there were no histological features that suggested lymphoma. Thus, a diagnosis of monoclonal RBG/RBD was made. Helicobacter pylori infection was found in 55.6% of RBG cases and in the RBD case. And, the clinical follow-up evaluations were uneventful. This report is the first study to describe this benign disease entity with monoclonality on a large-scale basis. In addition, the monoclonality of Mott cells cannot be used as evidence of an existing neoplastic lesion, and taken together, these findings may indicate a reactive process. (C) 2014 Elsevier Masson SAS. All rights reserved.

语种: 英语
WOS记录号: WOS:000345502400001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56068
Appears in Collections:北京大学第三临床医学院_消化科_期刊论文

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作者单位: Peking Univ Third Hosp, Dept Gastroenterol, Pathol Lab, Beijing 100191, Peoples R China

Recommended Citation:
Zhang, Hejun,Jin, Zhu,Cui, Rongli. Russell body gastritis/duodenitis: A case series and description of immunoglobulin light chain restriction[J]. CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY,2014,38(5):E89-E97.
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