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学科主题: 基础医学
题名:
Sulfated polysaccharides and immune response: promoter or inhibitor?
作者: Chen, D.; Wu, X. -Z.2; Wen, Z. -Y1
关键词: polysaccharides ; proteoglycans ; glycoproteins ; immune system ; inflammation
刊名: PANMINERVA MEDICA
发表日期: 2008-06-01
卷: 50, 期:2, 页:177-183
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: MOLECULAR LAMBDA-CARRAGEENAN ; MACROPHAGE MANNOSE RECEPTOR ; HEPARAN-SULFATE ; P-SELECTIN ; CHONDRUS-OCELLATUS ; MASS-SPECTROMETRY ; IN-VIVO ; BIOLOGICAL-ACTIVITIES ; GLUCAN SULFATES ; DENDRITIC CELLS
英文摘要:

Sulfated polysaccharides, which frequently connect to core protein, are expressed not only on cell surface but also throughout the extracellular matrix. Besides providing structural integrity of cells, sulfated polysaccharides interact with a variety of sulfated polysaccharides-binding proteins, such as growth factors, cytokines, chemokines and proteases. Sulfated polysaccharides play two-edged roles, inhibitor and promoter, in immune response. Some sulfated polysaccharides act as the immunosuppressor by blocking inflammatory signal transduction induced by proinflammatory cytokines, suppressing the activation of complement and inhibiting the process that leukocytes adhere to and pass through endothelium. On the contrary, the interaction between immune cells and sulfated polysaccharides produced by bacteria, endothelial cells and immune cells initiate the occurrence of immune response. It promotes the processes of recognizing and arresting antigen, migrating transendothelium, moving into and out of immune organ and enhancing the proliferation of lymphocyte. The structure of sulfated polysaccharides, such as molecular weight and sulfated sites heterogeneity, especially the degree of disaccharide sulfation, position of the sulfate moiety and organization of sulfated domains, may play critical role in their controversial effects. As a consequence, the interaction between sulfated polysaccharides and sulfated polysaccharide-binding proteins may be changed by modifying the structure of sulfated polysaccharides chains. The administration of drug targeting sulfated polysaccharide-protein interaction may be useful in treating inflammatory related diseases.

语种: 英语
项目资助者: National Natural Science
WOS记录号: WOS:000259569800010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56069
Appears in Collections:基础医学院_生物物理学系_期刊论文

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作者单位: 1.Peking Univ, Coll Med, Dept Med Phys, Dept Biophys, Beijing 100083, Peoples R China
2.Tianjin Med Univ, Canc Inst & Hosp, Tianjin, Peoples R China

Recommended Citation:
Chen, D.,Wu, X. -Z.,Wen, Z. -Y. Sulfated polysaccharides and immune response: promoter or inhibitor?[J]. PANMINERVA MEDICA,2008,50(2):177-183.
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