IR@PKUHSC  > 北京大学基础医学院  > 生物物理学系
学科主题基础医学
Sulfated polysaccharides and immune response: promoter or inhibitor?
Chen, D.; Wu, X. -Z.2; Wen, Z. -Y1
关键词Polysaccharides Proteoglycans Glycoproteins Immune System Inflammation
刊名PANMINERVA MEDICA
2008-06-01
50期:2页:177-183
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]MOLECULAR LAMBDA-CARRAGEENAN ; MACROPHAGE MANNOSE RECEPTOR ; HEPARAN-SULFATE ; P-SELECTIN ; CHONDRUS-OCELLATUS ; MASS-SPECTROMETRY ; IN-VIVO ; BIOLOGICAL-ACTIVITIES ; GLUCAN SULFATES ; DENDRITIC CELLS
英文摘要

Sulfated polysaccharides, which frequently connect to core protein, are expressed not only on cell surface but also throughout the extracellular matrix. Besides providing structural integrity of cells, sulfated polysaccharides interact with a variety of sulfated polysaccharides-binding proteins, such as growth factors, cytokines, chemokines and proteases. Sulfated polysaccharides play two-edged roles, inhibitor and promoter, in immune response. Some sulfated polysaccharides act as the immunosuppressor by blocking inflammatory signal transduction induced by proinflammatory cytokines, suppressing the activation of complement and inhibiting the process that leukocytes adhere to and pass through endothelium. On the contrary, the interaction between immune cells and sulfated polysaccharides produced by bacteria, endothelial cells and immune cells initiate the occurrence of immune response. It promotes the processes of recognizing and arresting antigen, migrating transendothelium, moving into and out of immune organ and enhancing the proliferation of lymphocyte. The structure of sulfated polysaccharides, such as molecular weight and sulfated sites heterogeneity, especially the degree of disaccharide sulfation, position of the sulfate moiety and organization of sulfated domains, may play critical role in their controversial effects. As a consequence, the interaction between sulfated polysaccharides and sulfated polysaccharide-binding proteins may be changed by modifying the structure of sulfated polysaccharides chains. The administration of drug targeting sulfated polysaccharide-protein interaction may be useful in treating inflammatory related diseases.

语种英语
WOS记录号WOS:000259569800010
资助机构National Natural Science
引用统计
被引频次:27[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56069
专题北京大学基础医学院_生物物理学系
作者单位1.Peking Univ, Coll Med, Dept Med Phys, Dept Biophys, Beijing 100083, Peoples R China
2.Tianjin Med Univ, Canc Inst & Hosp, Tianjin, Peoples R China
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GB/T 7714
Chen, D.,Wu, X. -Z.,Wen, Z. -Y. Sulfated polysaccharides and immune response: promoter or inhibitor?[J]. PANMINERVA MEDICA,2008,50(2):177-183.
APA Chen, D.,Wu, X. -Z.,&Wen, Z. -Y.(2008).Sulfated polysaccharides and immune response: promoter or inhibitor?.PANMINERVA MEDICA,50(2),177-183.
MLA Chen, D.,et al."Sulfated polysaccharides and immune response: promoter or inhibitor?".PANMINERVA MEDICA 50.2(2008):177-183.
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