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学科主题临床医学
Human defensins and cytokines in vaginal lavage fluid of women with bacterial vaginosis
Fan, S. R.2; Liu, X. P.1; Liao, Q. P.3
关键词Bacterial Vaginosis Human Beta-defensin 2 Human Defensin 5 Interleukin 4
刊名INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
2008-10-01
DOI10.1016/j.ijgo.2008.05.020
103期:1页:50-54
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Obstetrics & Gynecology
资助者National Key Technologies RD Program ; Shenzhen Science and Technology ; National Key Technologies RD Program ; Shenzhen Science and Technology
研究领域[WOS]Obstetrics & Gynecology
关键词[WOS]VIRUS-INFECTION ; GENITAL-TRACT ; NITRIC-OXIDE ; INTERLEUKIN-8 ; VAGINITIS ; IMMUNITY
英文摘要

Objective: To measure the concentrations of interferon gamma (IFN-gamma), interleukin (IL)-2, IL-4, IL-5, human beta-defensin 2 (HBD-2), and human defensin 5 (HD-5) in the vaginal lavage fluid (VLF) of healthy women and women with bacterial vaginosis (BV). Methods: VLF samples were obtained from 73 women with BV, 15 women with intermediate vaginal flora, 33 healthy women with vaginal pH greater than or equal to 4.5, and a control group of 39 healthy women with vaginal. pH less than 4.5. The concentrations of IFN-gamma, IL-2, IL-4, IL-5, HBD-2, and HD-5 were measured using enzyme-linked immunosorbent assay kits. Results: Concentrations of HBD-2 and HD-5 in the VLF of women with BV were significantly higher than in the control group (P < 0.05). IL-4 concentration was significantly lower in the VLF of women with BV than in the control group (P < 0.05). Conclusions: HBD-2 and HD-5 may be involved in defending against invasion by BV-related microorganisms and the decrease in IL-4 concentration may increase susceptibility to BV. (c) 2008 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.

语种英语
所属项目编号2004BA720A05-01 ; JA 20050527041913 ; 200702108 ; 200703031
资助者National Key Technologies RD Program ; Shenzhen Science and Technology ; National Key Technologies RD Program ; Shenzhen Science and Technology
WOS记录号WOS:000260275300012
引用统计
被引频次:29[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56076
专题北京大学深圳医院_检验科
作者单位1.Peking Univ, Shenzhen Hosp, Dept Lab Sci, Shenzhen 518036, Peoples R China
2.Peking Univ, Shenzhen Hosp, Dept Obstet & Gynecol, Shenzhen 518036, Peoples R China
3.Peking Univ, Hosp 1, Dept Obstet & Gynecol, Shenzhen 518036, Peoples R China
推荐引用方式
GB/T 7714
Fan, S. R.,Liu, X. P.,Liao, Q. P.. Human defensins and cytokines in vaginal lavage fluid of women with bacterial vaginosis[J]. INTERNATIONAL JOURNAL OF GYNECOLOGY &amp; OBSTETRICS,2008,103(1):50-54.
APA Fan, S. R.,Liu, X. P.,&Liao, Q. P..(2008).Human defensins and cytokines in vaginal lavage fluid of women with bacterial vaginosis.INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS,103(1),50-54.
MLA Fan, S. R.,et al."Human defensins and cytokines in vaginal lavage fluid of women with bacterial vaginosis".INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS 103.1(2008):50-54.
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