IR@PKUHSC  > 北京大学第三临床医学院
学科主题临床医学
Metabolic changes of H2S in smokers and patients of COPD which might involve in inflammation, oxidative stress and steroid sensitivity
Sun, Yun1; Wang, Keyi2; Li, Min-Xia1; He, Wei2; Chang, Jin-Rui3; Liao, Cheng-Cheng1; Lin, Fan1; Qi, Yong-Fen3; Wang, Rui4; Chen, Ya-Hong1
刊名SCIENTIFIC REPORTS
2015-10-12
DOI10.1038/srep14971
5
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]OBSTRUCTIVE PULMONARY-DISEASE ; REVERSES CORTICOSTEROID INSENSITIVITY ; ENDOGENOUS HYDROGEN-SULFIDE ; ALVEOLAR MACROPHAGES ; KAPPA-B ; LIPOPOLYSACCHARIDE ; EXPRESSION ; RESISTANCE ; PROTECTS ; PATHWAY
英文摘要

Oxidative stress and inflammation play crucial role in the pathogenesis of chronic obstructive pulmonary disease (COPD). Most patients with COPD show a poor response to corticosteroids. Hydrogen sulfide (H2S) has been implicated in the pathogenesis of COPD, but its expression and effects in lung tissue from COPD patients are not clear. In peripheral lung tissue samples from 24 patients, we found that compared with nonsmokers, the protein level of cystathionine-gamma-lyase (CSE) was decreased in smokers and COPD patients. CSE mRNA increased but cystathionine-beta-synthase (CBS) mRNA decreased in COPD patients. H2S donors increased glutathione and superoxide dismutase in CS exposed U937 cells and inhibited CS-induced TNF-alpha and IL-8 secretion. Dexamethasone alone had no effect on lipopolysaccharide (LPS) induced TNF-alpha release by alveolar macrophages from CS exposed rats, however the combination of dexamethasone and H2S donor significantly inhibited TNF-alpha release. Thus, H2S metabolism is altered in lung tissue of smokers and COPD patients. Supplementation of H2S protects against CS-induced oxidative stress and inflammation in macrophages and H2S on steroid sensitivity deserves further investigation.

语种英语
WOS记录号WOS:000362561700002
项目编号81170012 ; 81370141 ; 201002008 ; 2011-1004-01
资助机构National Nature Science Foundation of China ; Research Special Fund for Public Welfare Industry of Health ; Capital Medicine Development Fund
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56079
专题北京大学第三临床医学院
北京大学第二临床医学院_重症医学科
北京大学第三临床医学院_呼吸科
北京大学第三临床医学院_胸外科
作者单位1.Peking Univ, Dept Thorac Surg, Beijing 100191, Peoples R China
2.Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing 100191, Peoples R China
3.Lakehead Univ, Dept Biol, Thunder Bay, ON P7B 5E1, Canada
4.Peking Univ, Hosp 3, Pulm & Crit Care Med Dept, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Sun, Yun,Wang, Keyi,Li, Min-Xia,et al. Metabolic changes of H2S in smokers and patients of COPD which might involve in inflammation, oxidative stress and steroid sensitivity[J]. SCIENTIFIC REPORTS,2015,5.
APA Sun, Yun.,Wang, Keyi.,Li, Min-Xia.,He, Wei.,Chang, Jin-Rui.,...&Chen, Ya-Hong.(2015).Metabolic changes of H2S in smokers and patients of COPD which might involve in inflammation, oxidative stress and steroid sensitivity.SCIENTIFIC REPORTS,5.
MLA Sun, Yun,et al."Metabolic changes of H2S in smokers and patients of COPD which might involve in inflammation, oxidative stress and steroid sensitivity".SCIENTIFIC REPORTS 5(2015).
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