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学科主题: 临床医学
题名:
HTUPA as a new thrombolytic agent for acute myocardial infarction: A multicenter, randomized study
作者: Sun, Yingxian1; Liu, Xingli2; Guo, Liang1; Pang, Wenyue2; Guo, Xiaofan1; Sun, Zhaoqing2; Li, Zhanquan3; Cui, Xiaoying4; Li, Hui5; Tao, Guizhou6; Wang, Lanfeng7; Zhou, Changyong8; Liu, Ying3; Shan, Hongwei4; Wang, Manqing5; Liu, Mingxin6; Li, Jia7; Yin, Lei8; Hu, Dayi9
关键词: HTUPA ; rt-PA ; Acute myocardial infarction ; Patency ; Thrombolysis
刊名: INTERNATIONAL JOURNAL OF CARDIOLOGY
发表日期: 2014-03-15
DOI: 10.1016/j.ijcard.2013.12.018
卷: 172, 期:2, 页:326-331
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cardiac & Cardiovascular Systems
研究领域[WOS]: Cardiovascular System & Cardiology
关键词[WOS]: TISSUE-PLASMINOGEN-ACTIVATOR ; SELECTIVE CORONARY THROMBOLYSIS ; DOSE SYNERGISTIC COMBINATIONS ; ACUTE ISCHEMIC-STROKE ; PREHOSPITAL THROMBOLYSIS ; PRIMARY ANGIOPLASTY ; CLINICAL-TRIAL ; 5-HOUR WINDOW ; RT-PA ; UROKINASE
英文摘要:

Background: It is necessary to develop a new thrombolytic agent which can be used by a single bolus at first aid sites to decrease the time to reperfusion in clinical practice. HTUPA, a genetically engineered new thrombolytic with a longer half-life, is well qualified. We aim to compare the thrombolytic efficacy and safety of human tissue urokinase type plasminogen activator (HTUPA) to recombinant tissue plasminogen activator (rt-PA) in Chinese patients with acute myocardial infarction (AMI).

Methods: AMI patients (n = 221) were randomized to rt-PA (a standard protocol) or HTUPA (25 mg bolus) treatment groups. All patients also received oral aspirin and intravenous heparin. Coronary angiography was performed 90 min after therapy initiation to determine infarct-related coronary artery (IRA) patency. Clinical outcomes and changes of clotting variables, heart rate, blood pressure, left ventricular ejection fraction (LVEF), and electrocardiogram were evaluated.

Results: Patent IRA [thrombolysis in myocardial infarction (TIMI) grade 2 or 3] was observed in 77% of HTUPA-treated patients, compared to 76% of rt-PA-treated patients (P = 0.76). TIMI grade 3 patency rates were 52% and 44% in the HTUPA and rt-PA groups, respectively (P = 0.37). The total patency rate was 77% (86/111 patients) in the HTUPA group and 73% (80/110 patients) in the rt-PA group (P = 0.41). Adverse events were infrequent in both groups, and no significant differences were detected in mortality, re-occlusion rate, revascularization rate, adverse effects, clotting index, LVEF, or electrocardiogram between the two groups.

Conclusions: Intravenous HTUPA had a safe and efficacious profile as good as rt-PA in patients with AMI. (C) 2013 Published by Elsevier Ireland Ltd.

语种: 英语
WOS记录号: WOS:000332531800057
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56080
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.China Med Univ, Hosp 1, Dept Cardiol, Shenyang 110001, Peoples R China
2.China Med Univ, Shengjing Hosp, Dept Cardiol, Shenyang 110001, Peoples R China
3.Liaoning Prov Hosp, Dept Cardiol, Shenyang, Peoples R China
4.Inner Mongolia Univ, Dept Cardiol, Affiliated Hosp, Hohhot, Peoples R China
5.Gen Hosp Daqing Oil Field, Dept Cardiol, Daqing, Peoples R China
6.Liaoning Med Coll, Dept Cardiol, Affiliated Hosp, Jinzhou, Peoples R China
7.Harbin Med Univ, Affiliated Hosp 1, Dept Cardiol, Harbin, Peoples R China
8.Qingdao Univ, Sch Med, Affiliated Hosp, Dept Cardiol, Qingdao 266071, Peoples R China
9.Peking Univ, Peoples Hosp, Ctr Heart, Beijing 100871, Peoples R China

Recommended Citation:
Sun, Yingxian,Liu, Xingli,Guo, Liang,et al. HTUPA as a new thrombolytic agent for acute myocardial infarction: A multicenter, randomized study[J]. INTERNATIONAL JOURNAL OF CARDIOLOGY,2014,172(2):326-331.
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