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Evidence supporting the match/mismatch hypothesis of psychiatric disorders
Santarelli, Sara1; Lesuis, Sylvie L.1; Wang, Xiao-Dong2,3; Wagner, Klaus V.1; Hartmann, Jakob1; Labermaier, Christiana1; Scharf, Sebastian H.4; Mueller, Marianne B.1; Holsboer, Florian1; Schmidt, Mathias V.1
关键词Match/mismatch Hypothesis Cumulative Stress Hypothesis Stress Vulnerability Mouse Behavior Depression
刊名EUROPEAN NEUROPSYCHOPHARMACOLOGY
2014-06-01
DOI10.1016/j.euroneuro.2014.02.002
24期:6页:907-918
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Clinical Neurology ; Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
研究领域[WOS]Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
关键词[WOS]EARLY-LIFE ADVERSITY ; SOCIAL STRESS ; MATERNAL-CARE ; ESTROUS-CYCLE ; FEMALE RATS ; NEUROTROPHIC FACTOR ; CORTISOL RESPONSES ; CUMULATIVE STRESS ; MOOD DISORDERS ; DENTATE GYRUS
英文摘要

Chronic stress is one of the predominant environmental risk factors for a number of psychiatric disorders, particularly for major depression. Different hypotheses have been formulated to address the interaction between early and adult chronic stress in psychiatric disease vulnerability. The match/mismatch hypothesis of psychiatric disease states that the early life environment shapes coping strategies in a manner that enables individuals to optimally face similar environments later in life. We tested this hypothesis in female Balb/c mice that underwent either stress or enrichment early in life and were in adulthood further subdivided in single or group housed, in order to provide aversive or positive adult environments, respectively. We studied the effects,of the environmental manipulation on anxiety-like, depressive-like and sociability behaviors and gene expression profiles. We show that continuous exposure to adverse environments (matched condition) is not necessarily resulting in an opposite phenotype compared to a continuous supportive environment (matched condition). Rather, animals with mismatched environmental conditions behaved differently from animals with matched environments on anxious, social and depressive like phenotypes. These results further support the match/mismatch hypothesis and illustrate how mild or moderate aversive conditions during development can shape an individual to be optimally adapted to similar conditions later in life. (C) 2014 Elsevier B.V. and ECNP. All rights reserved.

语种英语
WOS记录号WOS:000336871900009
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被引频次:33[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56083
专题北京大学精神卫生研究所
作者单位1.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China
2.Max Planck Inst Psychiat, D-80804 Munich, Germany
3.Peking Univ, Minist Mental Hlth, Key Lab Mental Hlth, Beijing 100871, Peoples R China
4.Hoffmann La Roche Ag, Pharma Res & Early Dev, Discovery Neurosci, CH-4070 Basel, Switzerland
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GB/T 7714
Santarelli, Sara,Lesuis, Sylvie L.,Wang, Xiao-Dong,et al. Evidence supporting the match/mismatch hypothesis of psychiatric disorders[J]. EUROPEAN NEUROPSYCHOPHARMACOLOGY,2014,24(6):907-918.
APA Santarelli, Sara.,Lesuis, Sylvie L..,Wang, Xiao-Dong.,Wagner, Klaus V..,Hartmann, Jakob.,...&Schmidt, Mathias V..(2014).Evidence supporting the match/mismatch hypothesis of psychiatric disorders.EUROPEAN NEUROPSYCHOPHARMACOLOGY,24(6),907-918.
MLA Santarelli, Sara,et al."Evidence supporting the match/mismatch hypothesis of psychiatric disorders".EUROPEAN NEUROPSYCHOPHARMACOLOGY 24.6(2014):907-918.
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