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学科主题: 精神卫生
题名:
Evidence supporting the match/mismatch hypothesis of psychiatric disorders
作者: Santarelli, Sara1; Lesuis, Sylvie L.1; Wang, Xiao-Dong2,3; Wagner, Klaus V.1; Hartmann, Jakob1; Labermaier, Christiana1; Scharf, Sebastian H.4; Mueller, Marianne B.1; Holsboer, Florian1; Schmidt, Mathias V.1
关键词: Match/mismatch hypothesis ; Cumulative stress hypothesis ; Stress vulnerability ; Mouse ; Behavior ; Depression
刊名: EUROPEAN NEUROPSYCHOPHARMACOLOGY
发表日期: 2014-06-01
DOI: 10.1016/j.euroneuro.2014.02.002
卷: 24, 期:6, 页:907-918
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Clinical Neurology ; Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
研究领域[WOS]: Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
关键词[WOS]: EARLY-LIFE ADVERSITY ; SOCIAL STRESS ; MATERNAL-CARE ; ESTROUS-CYCLE ; FEMALE RATS ; NEUROTROPHIC FACTOR ; CORTISOL RESPONSES ; CUMULATIVE STRESS ; MOOD DISORDERS ; DENTATE GYRUS
英文摘要:

Chronic stress is one of the predominant environmental risk factors for a number of psychiatric disorders, particularly for major depression. Different hypotheses have been formulated to address the interaction between early and adult chronic stress in psychiatric disease vulnerability. The match/mismatch hypothesis of psychiatric disease states that the early life environment shapes coping strategies in a manner that enables individuals to optimally face similar environments later in life. We tested this hypothesis in female Balb/c mice that underwent either stress or enrichment early in life and were in adulthood further subdivided in single or group housed, in order to provide aversive or positive adult environments, respectively. We studied the effects,of the environmental manipulation on anxiety-like, depressive-like and sociability behaviors and gene expression profiles. We show that continuous exposure to adverse environments (matched condition) is not necessarily resulting in an opposite phenotype compared to a continuous supportive environment (matched condition). Rather, animals with mismatched environmental conditions behaved differently from animals with matched environments on anxious, social and depressive like phenotypes. These results further support the match/mismatch hypothesis and illustrate how mild or moderate aversive conditions during development can shape an individual to be optimally adapted to similar conditions later in life. (C) 2014 Elsevier B.V. and ECNP. All rights reserved.

语种: 英语
WOS记录号: WOS:000336871900009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56083
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China
2.Max Planck Inst Psychiat, D-80804 Munich, Germany
3.Peking Univ, Minist Mental Hlth, Key Lab Mental Hlth, Beijing 100871, Peoples R China
4.Hoffmann La Roche Ag, Pharma Res & Early Dev, Discovery Neurosci, CH-4070 Basel, Switzerland

Recommended Citation:
Santarelli, Sara,Lesuis, Sylvie L.,Wang, Xiao-Dong,et al. Evidence supporting the match/mismatch hypothesis of psychiatric disorders[J]. EUROPEAN NEUROPSYCHOPHARMACOLOGY,2014,24(6):907-918.
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