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学科主题: 临床医学
题名:
A meta-analysis of re-treatment for intravenous immunoglobulin-resistant Kawasaki disease
作者: Yang, Xi1,2; Liu, Guiying2; Huang, Yaqian1; Chen, Stella3; Du, Junbao1,4; Jin, Hongfang1
关键词: Mucocutaneous lymph node syndrome ; Kawasaki disease ; intravenous immunoglobulin ; glucocorticosteroid ; meta-analysis
刊名: CARDIOLOGY IN THE YOUNG
发表日期: 2015-08-01
DOI: 10.1017/S1047951114002601
卷: 25, 期:6, 页:1182-1190
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cardiac & Cardiovascular Systems ; Pediatrics
研究领域[WOS]: Cardiovascular System & Cardiology ; Pediatrics
关键词[WOS]: STEROID PULSE THERAPY ; ADDITIONAL IMMUNE GLOBULIN ; METHYLPREDNISOLONE PULSE
英文摘要:

Objective: To determine the optimal drug therapy for intravenous immunoglobulin-resistant Kawasaki disease. Methods: Studies regarding drug therapy for intravenous immunoglobulin-resistant Kawasaki disease were selected from medical electronic databases including PubMed, Medline, Elsevier, and Springer Link. The effectiveness in terms of temperature recovery and coronary artery damage was compared between a second intravenous immunoglobulin treatment and glucocorticosteroid treatment for children with intravenous immunoglobulin-resistant Kawasaki disease using meta-analysis with Review Manager 5.3 software. Indices to evaluate the effects were body temperature, biomarker levels, and coronary artery lesions detected by echocardiography. Results are reported as relative risks or odds ratio with a 95% confidence interval and p < 0.05. Results: Meta-analysis included 52 patients in the second intravenous immunoglobulin treatment group and 75 patients in the glucocorticosteroid treatment control group from four studies that met our inclusion criteria. Temperatures of patients who received glucocorticosteroid treatment were effectively controlled compared with those who received a second intravenous immunoglobulin treatment (relative risk = 0.73, 95% confidence interval: 0.58-0.92, p = 0.007). There were no differences, however, in the incidence of coronary artery lesions between the two groups (odds ratio = 1.55, 95% confidence interval: 0.57-4.20, p = 0.39). Conclusions: Glucocorticosteroids are more effective in controlling body temperature compared with intravenous immunoglobulin re-treatment in intravenous immunoglobulin-resistant Kawasaki disease children; however, glucocorticosteroids and intravenous immunoglobulin re-treatment showed no difference in the prevention of coronary artery lesions.

语种: 英语
所属项目编号: Z131100006813024
项目资助者: Beijing Municipal Plan for Science and Technology, China
WOS记录号: WOS:000361385200021
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56086
Appears in Collections:北京大学第一临床医学院_儿科_期刊论文

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作者单位: 1.Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing, Peoples R China
2.Peking Univ, Hosp 1, Dept Pediat, Beijing 100034, Peoples R China
3.Capital Med Univ, Beijing Anzhen Hosp, Dept Pediat, Beijing, Peoples R China
4.Univ Calif San Diego, Dept Biochem & Cellular Biol, San Diego, CA 92103 USA

Recommended Citation:
Yang, Xi,Liu, Guiying,Huang, Yaqian,et al. A meta-analysis of re-treatment for intravenous immunoglobulin-resistant Kawasaki disease[J]. CARDIOLOGY IN THE YOUNG,2015,25(6):1182-1190.
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