北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 基础医学院  > 放射医学教研室  > 期刊论文
学科主题: 基础医学
题名:
Microarray Based Screening of Peptide Nano Probes for HER2 Positive Tumor
作者: Wang, Zihua1; Wang, Weizhi1; Bu, Xiangli1; Wei, Zewen1; Geng, Lingling1; Wu, Yue2; Dong, Chengyan2; Li, Liqiang2; Zhang, Di1; Yang, Shu1; Wang, Fan2; Lausted, Christopher3; Hood, Leroy3; Hu, Zhiyuan1,3,4
刊名: ANALYTICAL CHEMISTRY
发表日期: 2015-08-18
DOI: 10.1021/acs.analchem.5b01588
卷: 87, 期:16, 页:8367-8372
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Analytical
研究领域[WOS]: Chemistry
关键词[WOS]: METASTATIC BREAST-CANCER ; ONE-COMPOUND LIBRARIES ; COMBINATORIAL LIBRARIES ; EXTRACELLULAR DOMAIN ; TARGETING PEPTIDES ; QUANTUM DOTS ; FACTOR-ALPHA ; BEAD ; CELLS ; IDENTIFICATION
英文摘要:

Peptides are excellent biointerface molecules and diagnostic probes with many advantages such as good penetration, short turnover time, and low cost. We report here an efficient peptide screening strategy based on in situ single bead sequencing on a microarray. Two novel peptides YLFFVFER (H6) and KLRLEWNR (H10) specifically binding to the tumor biomarker human epidermal growth factor receptor 2 (HER2) with aK(D) of 10(-8) M were obtained from a 10(5) library. Conjugated to nanoparticles, both the H6 and H10 probes showed specific accumulation in HER2-positive tumor tissues in xenografted mice by in vivo imaging.

语种: 英语
所属项目编号: 2144058 ; 21305023 ; 31270875 ; 31470049 ; 31400702 ; YZ201217
项目资助者: Beijing Natural Science Foundation ; National Natural Science Foundation of China ; Chinese Academy of Science
WOS记录号: WOS:000359892100049
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56091
Appears in Collections:基础医学院_放射医学教研室_期刊论文

Files in This Item:
File Name/ File Size Content Type Version Access License
Microarray Based Screening of Peptide Nano Probes for HER2 Positive Tumor.pdf(3089KB)期刊论文出版稿限制开放 联系获取全文

作者单位: 1.Inst Syst Biol, Seattle, WA 98109 USA
2.Natl Ctr Nanosci & Technol China, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China
3.Peking Univ, Sch Basic Med Sci, Dept Radiat Med, Med Isotopes Res Ctr, Beijing 100191, Peoples R China
4.Beijing Inst Radiat Med, Beijing Proteome Res Ctr, Beijing 102206, Peoples R China

Recommended Citation:
Wang, Zihua,Wang, Weizhi,Bu, Xiangli,et al. Microarray Based Screening of Peptide Nano Probes for HER2 Positive Tumor[J]. ANALYTICAL CHEMISTRY,2015,87(16):8367-8372.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Wang, Zihua]'s Articles
[Wang, Weizhi]'s Articles
[Bu, Xiangli]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Wang, Zihua]‘s Articles
[Wang, Weizhi]‘s Articles
[Bu, Xiangli]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace