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学科主题基础医学
Peroxisome Proliferator-Activated Receptor-gamma Ameliorates Pulmonary Arterial Hypertension by Inhibiting 5-Hydroxytryptamine 2B Receptor
Liu, Yahan1; Tian, Xiao Yu2; Mao, Guangmei1; Fang, Xi1; Fung, Man Lung3; Shyy, John Y. -J.4; Huang, Yu2; Wang, Nanping1,4
关键词Vasoconstriction Pulmonary Arterial Hypertension 5-hydroxytryptamine 2b Receptor Peroxisome Proliferator-activated Receptor-gamma
刊名HYPERTENSION
2012-12-01
DOI10.1161/HYPERTENSIONAHA.112.198887
60期:6页:1471-U261
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Peripheral Vascular Disease
研究领域[WOS]Cardiovascular System & Cardiology
关键词[WOS]ADENOVIRUS-MEDIATED OVEREXPRESSION ; INTERCELLULAR-ADHESION MOLECULE-1 ; PLASMA SEROTONIN LEVELS ; SMOOTH-MUSCLE-CELLS ; THERAPEUTIC TARGETS ; ENDOTHELIAL-CELLS ; C-JUN ; RATS ; ANTAGONIST ; DISEASE
英文摘要

An elevated plasma level of 5-hydroxytryptamine (5-HT) or upregulation of 5-HT receptor signaling or both is implicated in vascular contraction and remodeling in pulmonary arterial hypertension (PAH). Recently, peroxisome proliferator-activated receptor-gamma (PPAR gamma) agonists have been shown to ameliorate PAH. However, their effects on the 5-HT-induced contraction of pulmonary arteries remain unknown. Here, we examined the role of PPAR gamma in inhibiting 5-HT2B receptor (5-HT2BR) to ameliorate PAH. Pulmonary arteries from PAH rats induced by monocrotaline or chronic hypoxia showed an enhanced vasoconstriction in response to BW723C86, a specific agonist for 5-HT2BR. Expression of 5-HT2BR was also increased in pulmonary arteries from the PAH rats, accompanied by vascular remodeling and right ventricular hypertrophy. Treatment with the PPAR gamma agonist rosiglitazone in vivo reversed the expression and the vasocontractive effect of 5-HT2BR as well as the thickening of pulmonary arteries. In pulmonary artery smooth muscle cells, 5-HT induced the gene expression of 5-HT2BR, which was inhibited by rosiglitazone, pioglitazone, or adenovirus-mediated overexpression of constitutively activated PPAR gamma. The pharmacological effect of PPAR gamma was through the suppression of the 5-HT-induced activator protein-1 activity. These results demonstrated the beneficial effect of PPAR gamma on 5-HT2BR-mediated vasocontraction, providing a new mechanism for the potential use of PPAR gamma agonists in PAH. (Hypertension. 2012;60:1471-1478.)

语种英语
WOS记录号WOS:000311105900027
项目编号N_CUHK428/09 ; 30931160434 ; 30890041 ; 2010CB912500 ; CUHK46610
资助机构National Natural Science Foundation of China/Research Grants Council ; National Science Foundation of China ; Ministry of Science and Technology of China ; Hong Kong General Research Fund
引用统计
被引频次:29[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56092
专题北京大学基础医学院_心血管所
北京大学基础医学院
作者单位1.Peking Univ, Inst Cardiovasc Sci, Hlth Sci Ctr, Beijing 100191, Peoples R China
2.Chinese Univ Hong Kong, Sch Biomed Sci, Li Ka Shing Inst Hlth Sci, Inst Vasc Med, Hong Kong, Hong Kong, Peoples R China
3.Univ Hong Kong, Li Ka Shing Fac Med, Dept Physiol, Hong Kong, Hong Kong, Peoples R China
4.Xi An Jiao Tong Univ, Cardiovasc Res Ctr, Xian, Peoples R China
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GB/T 7714
Liu, Yahan,Tian, Xiao Yu,Mao, Guangmei,et al. Peroxisome Proliferator-Activated Receptor-gamma Ameliorates Pulmonary Arterial Hypertension by Inhibiting 5-Hydroxytryptamine 2B Receptor[J]. HYPERTENSION,2012,60(6):1471-U261.
APA Liu, Yahan.,Tian, Xiao Yu.,Mao, Guangmei.,Fang, Xi.,Fung, Man Lung.,...&Wang, Nanping.(2012).Peroxisome Proliferator-Activated Receptor-gamma Ameliorates Pulmonary Arterial Hypertension by Inhibiting 5-Hydroxytryptamine 2B Receptor.HYPERTENSION,60(6),1471-U261.
MLA Liu, Yahan,et al."Peroxisome Proliferator-Activated Receptor-gamma Ameliorates Pulmonary Arterial Hypertension by Inhibiting 5-Hydroxytryptamine 2B Receptor".HYPERTENSION 60.6(2012):1471-U261.
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