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Placental drug disposition and its clinical implications
Weier, Naomi2; He, Shu-Ming1; Li, Xiao-Tian3; Wang, Lin-Lin4,5; Zhou, Shu-Feng4
关键词Placenta Drug Metabolism Drug Transporter Cytochrome P450 P-glycoprotein
刊名CURRENT DRUG METABOLISM
2008-02-01
9期:2页:106-121
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
研究领域[WOS]Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
关键词[WOS]ARYLAMINE N-ACETYLTRANSFERASES ; CYTOSOLIC EPOXIDE HYDROLASE ; ANION TRANSPORTER 4 ; P-GLYCOPROTEIN ; TISSUE DISTRIBUTION ; PRENATAL EXPOSURE ; SUBCELLULAR-LOCALIZATION ; LATE PREGNANCY ; RAT PLACENTA ; GUINEA-PIG
英文摘要

The placenta is a unique organ that is essential to a healthy and normal pregnancy. A number of phase I and II metabolizing enzymes are expressed at moderate levels in the placenta, and have been proven to have the ability to metabolize certain xenobiotics. Depending on the substrate, this metabolic action may have significant clinical implications on how it affects the fetus. A wide variety of transporters including P-glycoprotein, breast cancer resistance protein, and multidrug resistance associated proteins have also been discovered in the placenta, and while most are found to have mainly physiological substrates, there are a number of xenobiotics which are also able to gain access to the fetus through transport across the placenta. Depending on the xenobiotics and its intended action, drug transport across the placenta may be desired, acceptable or undesirable. Medications administered to the mother but designed to work on the fetus are now being used increasingly, and demonstrates an important clinical implication in which drug transport across the placenta is desirable. However, medications designed to treat the mother but are also able to cross the placenta carry potential risks to damage the developing fetus, and it is therefore essential that the effects of different drugs on the fetus are known before they are administered during pregnancy. There is still much unknown about drug transport and drug metabolism in the placenta, and it is vital that in the future further research is done to discover the clinical implications of these activities in the placenta. This research is often complicated by the fact that it is unethical to run studies in pregnant women, and so research is often carried out in pregnant animals. These results are not always accurate, however, as the human′s placental structure is different from the placenta in other animals. Drug metabolism and drug transport across the placenta should continue to be researched, and guidelines need to be developed to ensure that any medications used during pregnancy are safe to both the mother and the fetus, and that successful treatment of the medical condition is carried out.

语种英语
WOS记录号WOS:000253936700002
引用统计
被引频次:19[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56093
专题北京大学公共卫生学院
作者单位1.Xiaolan Peoples Hosp, Dept Obstet & Genecol, Zhongshan, Guangdong, Peoples R China
2.Queensland Univ Technol, Sch Life Sci, Div Pharma, Brisbane, Qld, Australia
3.Fudan Univ, Obstet & Gynecol Hosp, Dept Maternal Med, Shanghai 200433, Peoples R China
4.RMIT Univ, WHO Collaborating Ctr Tradit Med, Sch Hlth Sci, Div Chinese Med, Melbourne, Vic, Australia
5.Peking Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Weier, Naomi,He, Shu-Ming,Li, Xiao-Tian,et al. Placental drug disposition and its clinical implications[J]. CURRENT DRUG METABOLISM,2008,9(2):106-121.
APA Weier, Naomi,He, Shu-Ming,Li, Xiao-Tian,Wang, Lin-Lin,&Zhou, Shu-Feng.(2008).Placental drug disposition and its clinical implications.CURRENT DRUG METABOLISM,9(2),106-121.
MLA Weier, Naomi,et al."Placental drug disposition and its clinical implications".CURRENT DRUG METABOLISM 9.2(2008):106-121.
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