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学科主题: 公共卫生
题名:
Placental drug disposition and its clinical implications
作者: Weier, Naomi2; He, Shu-Ming1; Li, Xiao-Tian3; Wang, Lin-Lin4,5; Zhou, Shu-Feng4
关键词: placenta ; drug metabolism ; drug transporter ; cytochrome P450 ; P-glycoprotein
刊名: CURRENT DRUG METABOLISM
发表日期: 2008-02-01
卷: 9, 期:2, 页:106-121
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
研究领域[WOS]: Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
关键词[WOS]: ARYLAMINE N-ACETYLTRANSFERASES ; CYTOSOLIC EPOXIDE HYDROLASE ; ANION TRANSPORTER 4 ; P-GLYCOPROTEIN ; TISSUE DISTRIBUTION ; PRENATAL EXPOSURE ; SUBCELLULAR-LOCALIZATION ; LATE PREGNANCY ; RAT PLACENTA ; GUINEA-PIG
英文摘要:

The placenta is a unique organ that is essential to a healthy and normal pregnancy. A number of phase I and II metabolizing enzymes are expressed at moderate levels in the placenta, and have been proven to have the ability to metabolize certain xenobiotics. Depending on the substrate, this metabolic action may have significant clinical implications on how it affects the fetus. A wide variety of transporters including P-glycoprotein, breast cancer resistance protein, and multidrug resistance associated proteins have also been discovered in the placenta, and while most are found to have mainly physiological substrates, there are a number of xenobiotics which are also able to gain access to the fetus through transport across the placenta. Depending on the xenobiotics and its intended action, drug transport across the placenta may be desired, acceptable or undesirable. Medications administered to the mother but designed to work on the fetus are now being used increasingly, and demonstrates an important clinical implication in which drug transport across the placenta is desirable. However, medications designed to treat the mother but are also able to cross the placenta carry potential risks to damage the developing fetus, and it is therefore essential that the effects of different drugs on the fetus are known before they are administered during pregnancy. There is still much unknown about drug transport and drug metabolism in the placenta, and it is vital that in the future further research is done to discover the clinical implications of these activities in the placenta. This research is often complicated by the fact that it is unethical to run studies in pregnant women, and so research is often carried out in pregnant animals. These results are not always accurate, however, as the human′s placental structure is different from the placenta in other animals. Drug metabolism and drug transport across the placenta should continue to be researched, and guidelines need to be developed to ensure that any medications used during pregnancy are safe to both the mother and the fetus, and that successful treatment of the medical condition is carried out.

语种: 英语
WOS记录号: WOS:000253936700002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56093
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Xiaolan Peoples Hosp, Dept Obstet & Genecol, Zhongshan, Guangdong, Peoples R China
2.Queensland Univ Technol, Sch Life Sci, Div Pharma, Brisbane, Qld, Australia
3.Fudan Univ, Obstet & Gynecol Hosp, Dept Maternal Med, Shanghai 200433, Peoples R China
4.RMIT Univ, WHO Collaborating Ctr Tradit Med, Sch Hlth Sci, Div Chinese Med, Melbourne, Vic, Australia
5.Peking Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Beijing 100083, Peoples R China

Recommended Citation:
Weier, Naomi,He, Shu-Ming,Li, Xiao-Tian,et al. Placental drug disposition and its clinical implications[J]. CURRENT DRUG METABOLISM,2008,9(2):106-121.
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