IR@PKUHSC  > 北京大学第一临床医学院  > 肾脏内科
学科主题临床医学
Distribution of reference GFR in a development population - a critical factor for the establishment of a GFR estimation equation
Ma, Y-C.1; Zuo, L.2; Su, Z-M.1; Chen, L.2; Meng, S.1; Li, J-J.1; Zhang, C-L.2; Wang, H-Y.2
关键词Mdrd Egfr Plasma Creatinine Chronic Kidney Disease
刊名CLINICAL NEPHROLOGY
2011-10-01
DOI10.5414/CN106912
76期:4页:296-305
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Urology & Nephrology
资助者Capital Development Grant of Beijing ; Beijing Science and Technology Committee ; Capital Development Grant of Beijing ; Beijing Science and Technology Committee
研究领域[WOS]Urology & Nephrology
关键词[WOS]CHRONIC KIDNEY-DISEASE ; GLOMERULAR-FILTRATION-RATE ; CHINESE PATIENTS ; PREVALENCE ; CLEARANCE
英文摘要

Background and aim: Our previous work showed that the performance of MDRD equations could be improved by modifying the original MDRD equation. However, during the modification we recognized that reference GFR (rGFR) distribution was not similar between the MDRD study and the Chinese Estimating GFR (eGFR) Investigation Study. This present study was designed to illustrate that the GFR estimating equation might be influenced by the difference of rGFR distribution in the development population. Racial factors might not be as important as once thought. Patients and methods: The Chinese eGFR Investigation Study dataset containing 684 CKD patients was defined as Dataset I, the modified MDRD equation for Chinese was defined as Equation I. Datasets II and III were generated respectively by deleting 125 cases of CKD Stage 1 from Dataset I and by adding 297 cases of apparently healthy Chinese adults into Dataset I. eGFR was estimated using Equation 1. Using rGFR as dependent and eGFR as independent, linear regression models were constructed using Dataset II and Dataset III, respectively, and generated Equation 2 and Equation 3. The prevalence of eGFR less than 60 ml/min/1.73 m(2) in the adult Beijing population was calculated using Equation 1, 2 and 3. Results: The previous reported prevalence of decreased GFR using Equation 1 in the Beijing adult population was 1.3% (0.8 - 1.8). By using Equation 2 and Equation 3, the prevalence increased to 3.2% (2.49 - 4.13) and decreased to 0.8% (0.57 - 1.28), respectively. Conclusions: GFR estimating equation was influenced by rGFR distribution of the development dataset.

语种英语
所属项目编号2007370003-Z07050700690720
资助者Capital Development Grant of Beijing ; Beijing Science and Technology Committee ; Capital Development Grant of Beijing ; Beijing Science and Technology Committee
WOS记录号WOS:000296476900006
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56094
专题北京大学第一临床医学院_肾脏内科
作者单位1.Capital Med Univ, Rehabil Med Coll, Beijing BoAi Hosp, China Rehabil Res Ctr,Dept Nephrol, Beijing 100068, Peoples R China
2.Peking Univ, Inst Nephrol, Hosp 1, Key Lab,Minist Hlth, Beijing 100871, Peoples R China
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GB/T 7714
Ma, Y-C.,Zuo, L.,Su, Z-M.,et al. Distribution of reference GFR in a development population - a critical factor for the establishment of a GFR estimation equation[J]. CLINICAL NEPHROLOGY,2011,76(4):296-305.
APA Ma, Y-C..,Zuo, L..,Su, Z-M..,Chen, L..,Meng, S..,...&Wang, H-Y..(2011).Distribution of reference GFR in a development population - a critical factor for the establishment of a GFR estimation equation.CLINICAL NEPHROLOGY,76(4),296-305.
MLA Ma, Y-C.,et al."Distribution of reference GFR in a development population - a critical factor for the establishment of a GFR estimation equation".CLINICAL NEPHROLOGY 76.4(2011):296-305.
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