IR@PKUHSC  > 北京大学第三临床医学院
学科主题临床医学
Genome-wide association analyses in Han Chinese identify two new susceptibility loci for amyotrophic lateral sclerosis
Deng, Min1; Wei, Ling2; Zuo, Xianbo3,4; Tian, Yanghua2; Xie, Fei2; Hu, Panpan2; Zhu, Chunyan2; Yu, Fengqiong2; Meng, Yu2; Wang, Honghao2; Zhang, Fangfang2; Ma, Huijuan2; Ye, Rong2; Cheng, Huaidong5; Du, Jing5; Dong, Wenwen2; Zhou, Shanshan2; Wang, Changqing2; Wang, Yu2; Wang, Jingye2; Chen, Xianwen2; Sun, Zhongwu2; Zhou, Nong2; Jiang, Yubao2; Liu, Xiuxiu6; Li, Xiaogang6; Zhang, Nan6; Liu, Na6; Guan, Yingjun7; Han, Yongsheng8; Han, Yongzhu8; Lv, Xinyi9; Fu, Yu9; Yu, Hui10; Xi, Chunhua11; Xie, Dandan12; Zhao, Qiyuan13; Xie, Peng14; Wang, Xin15; Zhang, Zhijun16; Shen, Lu17; Cui, Yong3,4; Yin, Xianyong3,4; Cheng, Hui3,4; Liang, Bo3,4; Zheng, Xiaodong3,4; Lee, Tatia M. C.18; Chen, Gang3,4; Zhou, Fusheng3,4; Veldink, Jan H.19; Robberecht, Wim20; Landers, John E.21; Andersen, Peter M.22; Al-Chalabi, Ammar23; Shaw, Chris23; Liu, Chunfeng24; Tang, Beisha17; Xiao, Shangxi25; Robertson, Janice25; Zhang, Fengyu26; van den Berg, Leonard H.; Sun, Liangdan3,4; Liu, Jianjun27,28,29; Yang, Sen3,4; Ju, Xiaodong30; Wang, Kai2; Zhang, Xuejun3,4
刊名NATURE GENETICS
2013-06-01
DOI10.1038/ng.2627
45期:6页:697-+
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Genetics & Heredity
研究领域[WOS]Genetics & Heredity
关键词[WOS]ALS ; APOPTOSIS ; PATHWAY ; GENE ; MECHANISMS ; CLONING ; CELLS ; GAMMA
英文摘要

To identify susceptibility genes for amyotrophic lateral sclerosis (ALS), we conducted a genome-wide association study (GWAS) in 506 individuals with sporadic ALS and 1,859 controls of Han Chinese ancestry. Ninety top SNPs suggested by the current GWAS and 6 SNPs identified by previous GWAS were analyzed in an independent cohort of 706 individuals with ALS and 1,777 controls of Han Chinese ancestry. We discovered two new susceptibility loci for ALS at 1q32 (CAMK1G, rs6703183, P-combined = 2.92 x 10(-8), odds ratio (OR) = 1.31) and 22p11 (CABIN1 and SUSD2, rs8141797, P-combined = 2.35 x 10(-9), OR = 1.52). These two loci explain 12.48% of the overall variance in disease risk in the Han Chinese population. We found no association evidence for the previously reported loci in the Han Chinese population, suggesting genetic heterogeneity of disease susceptibility for ALS between ancestry groups. Our study identifies two new susceptibility loci and suggests new pathogenic mechanisms of ALS.

语种英语
WOS记录号WOS:000319563900020
项目编号91232717 ; 2011CB707805 ; 81171273 ; 31000528 ; 81100806 ; 31100812 ; 31000503 ; 81070877 ; 20113420110001 ; 2007A008 ; 2009A04 ; 7112146 ; 7102159 ; 2007A008 ; 2009A04 ; 31171048 ; 81072374 ; 30973043 ; 30700906
资助机构Key Project of the National Natural Science Foundation of China ; National Basic Research Program of China ; National Natural Science Foundation of China ; Special Research Fund for the Doctoral Program of Higher Education ; Science and Technology New Star Funds of Beijing ; Beijing Science Foundation ; Beijing Nova Program ; A*STAR of Singapore ; National Nature Science Foundation of China
引用统计
被引频次:34[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56096
专题北京大学第三临床医学院
北京大学第三临床医学院_运动医学研究所
作者单位1.Umea Univ, Inst Pharmacol & Clin Neurosci, Umea, Sweden
2.Univ Toronto, Ctr Res Neurodegenerat Dis, Toronto, ON, Canada
3.Anhui Med Univ, Sch Life Sci, Hefei, Peoples R China
4.Suzhou First Peoples Hosp, Dept Neurol, Suzhou, Peoples R China
5.Anqing City Hosp, Dept Neurol, Anqing, Peoples R China
6.Luan First Peoples Hosp, Dept Neurol, Luan, Peoples R China
7.Peking Univ, Med Res Ctr, Hosp 3, Beijing 100871, Peoples R China
8.Weifang Med Univ, Dept Histol & Embryol, Weifang, Peoples R China
9.Anhui Coll Tradit Med, Inst Neurol, Hefei, Peoples R China
10.Anhui Prov Hosp, Dept Neurol, Hefei, Peoples R China
11.Anhui Med Univ, Dept Neurol, Affiliated Hosp 1, Hefei, Peoples R China
12.Anhui Med Univ, Dept Dermatol, Affiliated Hosp 1, Hefei, Peoples R China
13.Minist Natl Sci & Technol, State Key Lab Incubat Base Dermatol, Hefei, Peoples R China
14.Anhui Med Univ, Dept Neurol, Affiliated Hosp 2, Hefei, Peoples R China
15.Peking Univ, Dept Neurol, Hosp 3, Beijing 100871, Peoples R China
16.Anhui Med Univ, Dept Neurol, Affiliated Hosp 3, Hefei, Peoples R China
17.Chongqing Med Univ, Dept Neurol, Affiliated Hosp 1, Chongqing, Peoples R China
18.Fudan Univ, Dept Neurol, Zhongshan Hosp, Shanghai 200433, Peoples R China
19.Southeast Univ, Dept Neuropsychiat, Inst Neuropsychiat, Nanjing, Jiangsu, Peoples R China
20.Cent S Univ, Dept Neurol, Xiangya Hosp, Changsha, Hunan, Peoples R China
21.Univ Hong Kong, Lab Neuropsychol, Hong Kong, Hong Kong, Peoples R China
22.Univ Med Ctr, Dept Neurol, Utrecht, Netherlands
23.VIB, Dept Neurol, Neurobiol Lab, Vesalius Res Ctr, Louvain, Belgium
24.Univ Massachusetts, Sch Med, Dept Neurol, Worcester, MA USA
25.Kings Coll London, Dept Clin Neurosci, Inst Psychiat, Med Res Council Ctr Neurodegenerat Res, London WC2R 2LS, England
26.Soochow Univ, Dept Neurol, Affiliated Hosp 2, Suzhou, Peoples R China
27.NIMH, Clin Brain Disorder Branch, Bethesda, MD 20892 USA
28.ASTAR, Genome Inst Singapore, Singapore, Singapore
29.Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore 117548, Singapore
30.Peking Univ, Hosp 3, Inst Sports Med, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Deng, Min,Wei, Ling,Zuo, Xianbo,et al. Genome-wide association analyses in Han Chinese identify two new susceptibility loci for amyotrophic lateral sclerosis[J]. NATURE GENETICS,2013,45(6):697-+.
APA Deng, Min.,Wei, Ling.,Zuo, Xianbo.,Tian, Yanghua.,Xie, Fei.,...&Zhang, Xuejun.(2013).Genome-wide association analyses in Han Chinese identify two new susceptibility loci for amyotrophic lateral sclerosis.NATURE GENETICS,45(6),697-+.
MLA Deng, Min,et al."Genome-wide association analyses in Han Chinese identify two new susceptibility loci for amyotrophic lateral sclerosis".NATURE GENETICS 45.6(2013):697-+.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Deng, Min]的文章
[Wei, Ling]的文章
[Zuo, Xianbo]的文章
百度学术
百度学术中相似的文章
[Deng, Min]的文章
[Wei, Ling]的文章
[Zuo, Xianbo]的文章
必应学术
必应学术中相似的文章
[Deng, Min]的文章
[Wei, Ling]的文章
[Zuo, Xianbo]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。