北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第三临床医学院  > 期刊论文
学科主题: 临床医学
题名:
Genome-wide association analyses in Han Chinese identify two new susceptibility loci for amyotrophic lateral sclerosis
作者: Deng, Min1; Wei, Ling2; Zuo, Xianbo3,4; Tian, Yanghua2; Xie, Fei2; Hu, Panpan2; Zhu, Chunyan2; Yu, Fengqiong2; Meng, Yu2; Wang, Honghao2; Zhang, Fangfang2; Ma, Huijuan2; Ye, Rong2; Cheng, Huaidong5; Du, Jing5; Dong, Wenwen2; Zhou, Shanshan2; Wang, Changqing2; Wang, Yu2; Wang, Jingye2; Chen, Xianwen2; Sun, Zhongwu2; Zhou, Nong2; Jiang, Yubao2; Liu, Xiuxiu6; Li, Xiaogang6; Zhang, Nan6; Liu, Na6; Guan, Yingjun7; Han, Yongsheng8; Han, Yongzhu8; Lv, Xinyi9; Fu, Yu9; Yu, Hui10; Xi, Chunhua11; Xie, Dandan12; Zhao, Qiyuan13; Xie, Peng14; Wang, Xin15; Zhang, Zhijun16; Shen, Lu17; Cui, Yong3,4; Yin, Xianyong3,4; Cheng, Hui3,4; Liang, Bo3,4; Zheng, Xiaodong3,4; Lee, Tatia M. C.18; Chen, Gang3,4; Zhou, Fusheng3,4; Veldink, Jan H.19; Robberecht, Wim20; Landers, John E.21; Andersen, Peter M.22; Al-Chalabi, Ammar23; Shaw, Chris23; Liu, Chunfeng24; Tang, Beisha17; Xiao, Shangxi25; Robertson, Janice25; Zhang, Fengyu26; van den Berg, Leonard H.; Sun, Liangdan3,4; Liu, Jianjun27,28,29; Yang, Sen3,4; Ju, Xiaodong30; Wang, Kai2; Zhang, Xuejun3,4
刊名: NATURE GENETICS
发表日期: 2013-06-01
DOI: 10.1038/ng.2627
卷: 45, 期:6, 页:697-+
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Genetics & Heredity
研究领域[WOS]: Genetics & Heredity
关键词[WOS]: ALS ; APOPTOSIS ; PATHWAY ; GENE ; MECHANISMS ; CLONING ; CELLS ; GAMMA
英文摘要:

To identify susceptibility genes for amyotrophic lateral sclerosis (ALS), we conducted a genome-wide association study (GWAS) in 506 individuals with sporadic ALS and 1,859 controls of Han Chinese ancestry. Ninety top SNPs suggested by the current GWAS and 6 SNPs identified by previous GWAS were analyzed in an independent cohort of 706 individuals with ALS and 1,777 controls of Han Chinese ancestry. We discovered two new susceptibility loci for ALS at 1q32 (CAMK1G, rs6703183, P-combined = 2.92 x 10(-8), odds ratio (OR) = 1.31) and 22p11 (CABIN1 and SUSD2, rs8141797, P-combined = 2.35 x 10(-9), OR = 1.52). These two loci explain 12.48% of the overall variance in disease risk in the Han Chinese population. We found no association evidence for the previously reported loci in the Han Chinese population, suggesting genetic heterogeneity of disease susceptibility for ALS between ancestry groups. Our study identifies two new susceptibility loci and suggests new pathogenic mechanisms of ALS.

语种: 英语
所属项目编号: 91232717 ; 2011CB707805 ; 81171273 ; 31000528 ; 81100806 ; 31100812 ; 31000503 ; 81070877 ; 20113420110001 ; 2007A008 ; 2009A04 ; 7112146 ; 7102159 ; 2007A008 ; 2009A04 ; 31171048 ; 81072374 ; 30973043 ; 30700906
项目资助者: Key Project of the National Natural Science Foundation of China ; National Basic Research Program of China ; National Natural Science Foundation of China ; Special Research Fund for the Doctoral Program of Higher Education ; Science and Technology New Star Funds of Beijing ; Beijing Science Foundation ; Beijing Nova Program ; A*STAR of Singapore ; National Nature Science Foundation of China
WOS记录号: WOS:000319563900020
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56096
Appears in Collections:北京大学第三临床医学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Umea Univ, Inst Pharmacol & Clin Neurosci, Umea, Sweden
2.Univ Toronto, Ctr Res Neurodegenerat Dis, Toronto, ON, Canada
3.Anhui Med Univ, Sch Life Sci, Hefei, Peoples R China
4.Suzhou First Peoples Hosp, Dept Neurol, Suzhou, Peoples R China
5.Anqing City Hosp, Dept Neurol, Anqing, Peoples R China
6.Luan First Peoples Hosp, Dept Neurol, Luan, Peoples R China
7.Peking Univ, Med Res Ctr, Hosp 3, Beijing 100871, Peoples R China
8.Weifang Med Univ, Dept Histol & Embryol, Weifang, Peoples R China
9.Anhui Coll Tradit Med, Inst Neurol, Hefei, Peoples R China
10.Anhui Prov Hosp, Dept Neurol, Hefei, Peoples R China
11.Anhui Med Univ, Dept Neurol, Affiliated Hosp 1, Hefei, Peoples R China
12.Anhui Med Univ, Dept Dermatol, Affiliated Hosp 1, Hefei, Peoples R China
13.Minist Natl Sci & Technol, State Key Lab Incubat Base Dermatol, Hefei, Peoples R China
14.Anhui Med Univ, Dept Neurol, Affiliated Hosp 2, Hefei, Peoples R China
15.Peking Univ, Dept Neurol, Hosp 3, Beijing 100871, Peoples R China
16.Anhui Med Univ, Dept Neurol, Affiliated Hosp 3, Hefei, Peoples R China
17.Chongqing Med Univ, Dept Neurol, Affiliated Hosp 1, Chongqing, Peoples R China
18.Fudan Univ, Dept Neurol, Zhongshan Hosp, Shanghai 200433, Peoples R China
19.Southeast Univ, Dept Neuropsychiat, Inst Neuropsychiat, Nanjing, Jiangsu, Peoples R China
20.Cent S Univ, Dept Neurol, Xiangya Hosp, Changsha, Hunan, Peoples R China
21.Univ Hong Kong, Lab Neuropsychol, Hong Kong, Hong Kong, Peoples R China
22.Univ Med Ctr, Dept Neurol, Utrecht, Netherlands
23.VIB, Dept Neurol, Neurobiol Lab, Vesalius Res Ctr, Louvain, Belgium
24.Univ Massachusetts, Sch Med, Dept Neurol, Worcester, MA USA
25.Kings Coll London, Dept Clin Neurosci, Inst Psychiat, Med Res Council Ctr Neurodegenerat Res, London WC2R 2LS, England
26.Soochow Univ, Dept Neurol, Affiliated Hosp 2, Suzhou, Peoples R China
27.NIMH, Clin Brain Disorder Branch, Bethesda, MD 20892 USA
28.ASTAR, Genome Inst Singapore, Singapore, Singapore
29.Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore 117548, Singapore
30.Peking Univ, Hosp 3, Inst Sports Med, Beijing 100871, Peoples R China

Recommended Citation:
Deng, Min,Wei, Ling,Zuo, Xianbo,et al. Genome-wide association analyses in Han Chinese identify two new susceptibility loci for amyotrophic lateral sclerosis[J]. NATURE GENETICS,2013,45(6):697-+.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Deng, Min]'s Articles
[Wei, Ling]'s Articles
[Zuo, Xianbo]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Deng, Min]‘s Articles
[Wei, Ling]‘s Articles
[Zuo, Xianbo]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace