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Case-control association study of the 2 ′,3 ′-cyclic nucleotide 3 ′-phosphodiesterase (CNP) gene and schizophrenia in the Han Chinese population
Tang, Fulei; Qu, Mei; Wang, Lifang; Ruan, Yan; Lu, Tianlan; Zhang, Handi; Liu, Zhonghua; Yue, Weihua; Zhang, Dai
关键词Myelination Oligodendrocyte Haplotype
刊名NEUROSCIENCE LETTERS
2007-04-12
DOI10.1016/j.neulet.2007.01.054
416期:2页:113-116
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]MYELINATION ; DYSFUNCTION ; POSTMORTEM ; EXPRESSION ; LINKAGE ; LOCI
英文摘要

Converging evidence from imaging, microarray, genetic, and other studies suggests that abnormalities in myelin may play a role in schizophrenia. The expression of 2′,3′-cyclic nucleotide 3′-phosphodiesterase (CNP), which is used as a myel in marker, has been reported to be reduced in the schizophrenic brain. A synonymous genetic variation in the CNP gene, rs2070106, has recently been shown to be associated with schizophrenia in Caucasians. The present study investigates whether this finding can be replicated in the Han Chinese population. We performed an association analysis of four ht-SNPs in the CNP gene in a Chinese sample consisting of 426 schizophrenic patients and 439 healthy controls. We did not find any significant differences in any genotypic, allelic or haplotypic distributions between patients and controls. Therefore, this study did not find an association between genetic variations in the CNP gene and schizophrenia in the Han Chinese population. (c) 2007 Elsevier Ireland Ltd. All rights reserved.

语种英语
WOS记录号WOS:000246039100002
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56098
专题北京大学精神卫生研究所
作者单位Peking Univ, Inst Mental Hlth, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Tang, Fulei,Qu, Mei,Wang, Lifang,et al. Case-control association study of the 2 ′,3 ′-cyclic nucleotide 3 ′-phosphodiesterase (CNP) gene and schizophrenia in the Han Chinese population[J]. NEUROSCIENCE LETTERS,2007,416(2):113-116.
APA Tang, Fulei.,Qu, Mei.,Wang, Lifang.,Ruan, Yan.,Lu, Tianlan.,...&Zhang, Dai.(2007).Case-control association study of the 2 ′,3 ′-cyclic nucleotide 3 ′-phosphodiesterase (CNP) gene and schizophrenia in the Han Chinese population.NEUROSCIENCE LETTERS,416(2),113-116.
MLA Tang, Fulei,et al."Case-control association study of the 2 ′,3 ′-cyclic nucleotide 3 ′-phosphodiesterase (CNP) gene and schizophrenia in the Han Chinese population".NEUROSCIENCE LETTERS 416.2(2007):113-116.
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