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学科主题: 精神卫生
题名:
Case-control association study of the 2 ′,3 ′-cyclic nucleotide 3 ′-phosphodiesterase (CNP) gene and schizophrenia in the Han Chinese population
作者: Tang, Fulei; Qu, Mei; Wang, Lifang; Ruan, Yan; Lu, Tianlan; Zhang, Handi; Liu, Zhonghua; Yue, Weihua; Zhang, Dai
关键词: myelination ; oligodendrocyte ; haplotype
刊名: NEUROSCIENCE LETTERS
发表日期: 2007-04-12
DOI: 10.1016/j.neulet.2007.01.054
卷: 416, 期:2, 页:113-116
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: MYELINATION ; DYSFUNCTION ; POSTMORTEM ; EXPRESSION ; LINKAGE ; LOCI
英文摘要:

Converging evidence from imaging, microarray, genetic, and other studies suggests that abnormalities in myelin may play a role in schizophrenia. The expression of 2′,3′-cyclic nucleotide 3′-phosphodiesterase (CNP), which is used as a myel in marker, has been reported to be reduced in the schizophrenic brain. A synonymous genetic variation in the CNP gene, rs2070106, has recently been shown to be associated with schizophrenia in Caucasians. The present study investigates whether this finding can be replicated in the Han Chinese population. We performed an association analysis of four ht-SNPs in the CNP gene in a Chinese sample consisting of 426 schizophrenic patients and 439 healthy controls. We did not find any significant differences in any genotypic, allelic or haplotypic distributions between patients and controls. Therefore, this study did not find an association between genetic variations in the CNP gene and schizophrenia in the Han Chinese population. (c) 2007 Elsevier Ireland Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000246039100002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56098
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: Peking Univ, Inst Mental Hlth, Beijing 100083, Peoples R China

Recommended Citation:
Tang, Fulei,Qu, Mei,Wang, Lifang,et al. Case-control association study of the 2 ′,3 ′-cyclic nucleotide 3 ′-phosphodiesterase (CNP) gene and schizophrenia in the Han Chinese population[J]. NEUROSCIENCE LETTERS,2007,416(2):113-116.
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