IR@PKUHSC  > 北京大学第二临床医学院
学科主题临床医学
Nifedipine inhibits the activation of inflammatory and immune reactions in viral myocarditis
Liu, Wenling2; Shimada, Miho; Xiao, Jie2,3; Hu, Dayi2; Matsumori, Akira1
关键词Necrosis Matrix Metalloproteinases Mast Cell Proteases Proinflammatory Cytokines
刊名LIFE SCIENCES
2009-07-29
DOI10.1016/j.lfs.2009.05.018
85期:5-6页:235-240
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental ; Pharmacology & Pharmacy
研究领域[WOS]Research & Experimental Medicine ; Pharmacology & Pharmacy
关键词[WOS]NF-KAPPA-B ; CONGESTIVE-HEART-FAILURE ; CALCIUM-CHANNEL BLOCKERS ; MAST-CELL DENSITY ; TRANSCRIPTION FACTORS ; IN-VITRO ; GENE-EXPRESSION ; MURINE MODEL ; CARDIOMYOPATHY ; PATHOGENESIS
英文摘要

Aims: The aim of study is to investigate the effect of nifedipine on Viral myocarditis in an animal model.

Main methods: Four-week-old male DBA/2 mice were inoculated with 2 pfu of encephalomyocarditis virus (EMCV) and randomized to nifedipine (n = 10) or control (n = 10) group. The control group was fed by regular chow and the nifedipine group contained 0.01% of nifedipine. Mast cell density was Counted, and expressions of messenger RNAs of stem cell factor (SCF), matrix metalloproteinases (MMPs), pro-collagen 1, mast cell proteases, tumor necrosis factor-alpha (TNF-alpha), and interleukin-6 (IL-6) were evaluated by RT-PCR.

Key findings: The area of myocardial necrosis was smaller in the nifedipine vs the control group (mean +/- SD, 1.2 +/- 1.3% vs 3.8 +/- 1.8%, respectively, P<0.005). The mast cell density (count/mm(2)) was lower in the nifedipine vs the control group (mean SD, 0.23 +/- 0.16 vs 1.08 +/- 0.45, respectively, P<0.0005). The expressions of MMPs, mast cell proteases, TNF-alpha, IL-6, SCIF and pro-collagen I were lower in the nifeclipine group than in the control group (P<0.05).

Significance: Nifedipine inhibited the activation of various participants in inflammatory and immune reactions in EMCV myocarditis. (C) 2009 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000268212100008
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56102
专题北京大学第二临床医学院
作者单位1.Peking Univ, Peoples Hosp, Beijing 100871, Peoples R China
2.Kyoto Univ, Grad Sch Med, Dept Cardiovasc Med, Sakyo Ku, Kyoto 6068507, Japan
3.Capital Med Univ, Beijing Tongren Hosp, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Liu, Wenling,Shimada, Miho,Xiao, Jie,et al. Nifedipine inhibits the activation of inflammatory and immune reactions in viral myocarditis[J]. LIFE SCIENCES,2009,85(5-6):235-240.
APA Liu, Wenling,Shimada, Miho,Xiao, Jie,Hu, Dayi,&Matsumori, Akira.(2009).Nifedipine inhibits the activation of inflammatory and immune reactions in viral myocarditis.LIFE SCIENCES,85(5-6),235-240.
MLA Liu, Wenling,et al."Nifedipine inhibits the activation of inflammatory and immune reactions in viral myocarditis".LIFE SCIENCES 85.5-6(2009):235-240.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Liu, Wenling]的文章
[Shimada, Miho]的文章
[Xiao, Jie]的文章
百度学术
百度学术中相似的文章
[Liu, Wenling]的文章
[Shimada, Miho]的文章
[Xiao, Jie]的文章
必应学术
必应学术中相似的文章
[Liu, Wenling]的文章
[Shimada, Miho]的文章
[Xiao, Jie]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。