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Complement Activation Is Involved in Renal Damage in Human Antineutrophil Cytoplasmic Autoantibody Associated Pauci-Immune Vasculitis
Xing, Guang-qun1; Chen, Min1; Liu, Gang1; Heeringa, Peter3; Zhang, Jun-jun1; Zheng, Xin1; Jie, E.1; Kallenberg, Cees G. M.2; Zhao, Ming-hui1
关键词Anca Complement Histopathology Myeloperoxidase Pauci-immune Vasculitis
刊名JOURNAL OF CLINICAL IMMUNOLOGY
2009-05-01
DOI10.1007/s10875-008-9268-2
29期:3页:282-291
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Immunology
研究领域[WOS]Immunology
关键词[WOS]ANCA-ASSOCIATED VASCULITIS ; LECTIN PATHWAY ; CRESCENTIC GLOMERULONEPHRITIS ; DEPOSITS ; DISEASE ; PATHOGENESIS ; EXPRESSION ; ANTIBODIES ; NEPHRITIS ; BIOLOGY
英文摘要

This study was to investigate the evidence for complement activation in renal biopsy specimens of patients with myeloperoxidase (MPO)-antineutrophil cytoplasmic autoantibody (ANCA)-associated pauci-immune vasculitis.

Renal biopsy specimens from seven patients with MPO-ANCA positive pauci-immune necrotizing crescentic glomerulonephritis (NCGN) were used to detect the staining of membrane attack complex (MAC), C3d, C4d, mannose-binding lectin (MBL), factor B and factor P using immunohistochemistry and immunofluorescence. Renal tissue from seven patients with minimal change disease (MCD) and two normal renal tissue were used as controls.

MAC, C3d, factor B and factor P could be detected in glomeruli and small blood vessels with active vasculitis of patients with pauci-immune AAV, but not or scarcely in patients with MCD and in normal renal tissue. C3d and factor B co-localized with MAC, factor P colocalized with C3d. MBL and C4d were not detected in patients with AAV.

The alternative pathway of the complement system is involved in renal damage of human pauci-immune AAV.

语种英语
WOS记录号WOS:000266038600005
项目编号30725034 ; 985-2-104113 ; NWO VIDI 917.66.342 ; PC 07-2204
资助机构National Science Fund for Distinguished Young Scholars ; Chinese 985 project ; Dutch Organization for Scientific research ; Dutch Kidney Foundation
引用统计
被引频次:94[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56103
专题北京大学第一临床医学院_肾脏内科
作者单位1.Peking Univ, Inst Nephrol, Dept Med, Div Renal,Hosp 1,Key Lab Renal Dis,Minist Hlth Ch, Beijing 100034, Peoples R China
2.Univ Groningen, Univ Med Ctr Groningen, Dept Clin Immunol, NL-9713 AV Groningen, Netherlands
3.Univ Med Ctr Groningen, Dept Pathol & Med Biol, NL-9713 AV Groningen, Netherlands
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GB/T 7714
Xing, Guang-qun,Chen, Min,Liu, Gang,et al. Complement Activation Is Involved in Renal Damage in Human Antineutrophil Cytoplasmic Autoantibody Associated Pauci-Immune Vasculitis[J]. JOURNAL OF CLINICAL IMMUNOLOGY,2009,29(3):282-291.
APA Xing, Guang-qun.,Chen, Min.,Liu, Gang.,Heeringa, Peter.,Zhang, Jun-jun.,...&Zhao, Ming-hui.(2009).Complement Activation Is Involved in Renal Damage in Human Antineutrophil Cytoplasmic Autoantibody Associated Pauci-Immune Vasculitis.JOURNAL OF CLINICAL IMMUNOLOGY,29(3),282-291.
MLA Xing, Guang-qun,et al."Complement Activation Is Involved in Renal Damage in Human Antineutrophil Cytoplasmic Autoantibody Associated Pauci-Immune Vasculitis".JOURNAL OF CLINICAL IMMUNOLOGY 29.3(2009):282-291.
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