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学科主题: 临床医学
题名:
Complement Activation Is Involved in Renal Damage in Human Antineutrophil Cytoplasmic Autoantibody Associated Pauci-Immune Vasculitis
作者: Xing, Guang-qun1; Chen, Min1; Liu, Gang1; Heeringa, Peter3; Zhang, Jun-jun1; Zheng, Xin1; Jie, E.1; Kallenberg, Cees G. M.2; Zhao, Ming-hui1
关键词: ANCA ; complement ; histopathology ; myeloperoxidase ; pauci-immune ; vasculitis
刊名: JOURNAL OF CLINICAL IMMUNOLOGY
发表日期: 2009-05-01
DOI: 10.1007/s10875-008-9268-2
卷: 29, 期:3, 页:282-291
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Immunology
研究领域[WOS]: Immunology
关键词[WOS]: ANCA-ASSOCIATED VASCULITIS ; LECTIN PATHWAY ; CRESCENTIC GLOMERULONEPHRITIS ; DEPOSITS ; DISEASE ; PATHOGENESIS ; EXPRESSION ; ANTIBODIES ; NEPHRITIS ; BIOLOGY
英文摘要:

This study was to investigate the evidence for complement activation in renal biopsy specimens of patients with myeloperoxidase (MPO)-antineutrophil cytoplasmic autoantibody (ANCA)-associated pauci-immune vasculitis.

Renal biopsy specimens from seven patients with MPO-ANCA positive pauci-immune necrotizing crescentic glomerulonephritis (NCGN) were used to detect the staining of membrane attack complex (MAC), C3d, C4d, mannose-binding lectin (MBL), factor B and factor P using immunohistochemistry and immunofluorescence. Renal tissue from seven patients with minimal change disease (MCD) and two normal renal tissue were used as controls.

MAC, C3d, factor B and factor P could be detected in glomeruli and small blood vessels with active vasculitis of patients with pauci-immune AAV, but not or scarcely in patients with MCD and in normal renal tissue. C3d and factor B co-localized with MAC, factor P colocalized with C3d. MBL and C4d were not detected in patients with AAV.

The alternative pathway of the complement system is involved in renal damage of human pauci-immune AAV.

语种: 英语
所属项目编号: 30725034 ; 985-2-104113 ; NWO VIDI 917.66.342 ; PC 07-2204
项目资助者: National Science Fund for Distinguished Young Scholars ; Chinese 985 project ; Dutch Organization for Scientific research ; Dutch Kidney Foundation
WOS记录号: WOS:000266038600005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56103
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: 1.Peking Univ, Inst Nephrol, Dept Med, Div Renal,Hosp 1,Key Lab Renal Dis,Minist Hlth Ch, Beijing 100034, Peoples R China
2.Univ Groningen, Univ Med Ctr Groningen, Dept Clin Immunol, NL-9713 AV Groningen, Netherlands
3.Univ Med Ctr Groningen, Dept Pathol & Med Biol, NL-9713 AV Groningen, Netherlands

Recommended Citation:
Xing, Guang-qun,Chen, Min,Liu, Gang,et al. Complement Activation Is Involved in Renal Damage in Human Antineutrophil Cytoplasmic Autoantibody Associated Pauci-Immune Vasculitis[J]. JOURNAL OF CLINICAL IMMUNOLOGY,2009,29(3):282-291.
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