|Urinary Prostate-Specific Antigen is Elevated in Female Patients with Cushing′s Syndrome|
|Wang, Tiancheng1; Wu, Yonghua1; Xiao, Wenhua2; Gao, Hongwei2; Li, Zhenrong1|
|关键词||Female Cushing&Prime s Syndrome Prostate-specific Antigen 17-ketosteroids 17-hydroxycorticosteroids|
|WOS标题词||Science & Technology|
|类目[WOS]||Medical Laboratory Technology|
|研究领域[WOS]||Medical Laboratory Technology|
|关键词[WOS]||TO-MALE TRANSSEXUALS ; KALLIKREIN CONCENTRATIONS ; WOMEN ; CANCER ; SERUM ; MARKER ; PSA ; HYPERANDROGENISM ; EXPRESSION ; DIAGNOSIS|
Background: It has been demonstrated that the expression of prostate-specific antigen (PSA) is known to not be organ or gender specific but rather a steroid hormone mediated response, and the level of PSA is elevated in the serum of women with hyperandrogenic syndromes. The urinary profile of PSA in female subjects is less clear. We investigated the expression of urinary PSA in female subjects with Cushing′s syndrome and the relationship between urinary PSA and 2 steroid hormonal metabolites, 17-hydroxycorticosteroids (17-OHCS) and 17-ketosteroids (17-KS).
Methods: We classified 97 female patients into 1 of 3 groups: Group A (n=37), patients with Cushing′s syndrome (n=30), or adrenocortical hyperplasia (n=7); Group B (n=29), patients with primary hyperaldosteronism (n=18) or pheochromocytoma (n=11); and Group C (n=31), patients with non-adrenal diseases, including hypertension (n=12) and Type 2 diabetes (n=19). Patients with Cushing′s syndrome or primary hyperaldosteronism were defined by clinical symptoms and laboratory confirmation. Patients with pheochromocytoma were defined by clinical symptoms, laboratory confirmation, and computed tomography or MRI. Patients with non-adrenal diseases were defined by a serum cortisol and plasma adrenocorticotropic hormone (ACTH) level within normal limits. Patients taking any medications in this category were excluded. Biochemical indicators related to the steroid hormonal metabolism, such as 17-OHCS, 17-KS, PSA, and creatinine (Cre) of 24-hour urine in these subjects were measured. The 17-OHCS, 17-KS, and PSA were all adjusted for 24-hour urinary Ore.
Results: The 24-hour urinary PSA levels were significantly higher (P<0.0001) in the female patients with Cushing′s syndrome (mean +/- SE=17.52 +/- 2.10 mu g/mol Ore) than in the controls (mean +/- SE=4.65 +/- 1.23 mu g/mol Ore). Similarly, there was also a significant difference (P<0.01) between 24-hour urinary 17-KS of the female patients (mean +/- SE=7.17 +/- 0.59 mmol/mol Ore) and the controls (6.17 +/- 0.55 mmol/mol Ore). A correlation was observed between 24-hour urinary PSA level and 24-hour urinary 17-KS concentration (rs=0.720, P<0.01). In Group A, the area under the curve (AUC) value of PSA (0.853, P<0.001) was greater than that of 17-OHCS (0.811, P<0.001) and 17-KS (0.693, P<0.01), respectively. In Group B, the AUC value of PSA (0.722, P<0.01) was greater than that of 17-OHCS (0.663, P>0.01) and 17-KS (0.632, P>0.01), respectively.
Conclusions: Urinary PSA was elevated in female patients with Cushing′s syndrome. It indicates that urinary PSA may be an additional parameter for a better definition of female " patients suffering from Cushing′s syndrome.
|作者单位||1.Peking Univ, Hosp 3, Dept Lab Med, Beijing 100871, Peoples R China|
2.Peking Univ, Hosp 3, Dept Endocrinol, Beijing 100871, Peoples R China
|Wang, Tiancheng,Wu, Yonghua,Xiao, Wenhua,et al. Urinary Prostate-Specific Antigen is Elevated in Female Patients with Cushing′s Syndrome[J]. LABMEDICINE,2011,42(2):102-105.|
|APA||Wang, Tiancheng,Wu, Yonghua,Xiao, Wenhua,Gao, Hongwei,&Li, Zhenrong.(2011).Urinary Prostate-Specific Antigen is Elevated in Female Patients with Cushing′s Syndrome.LABMEDICINE,42(2),102-105.|
|MLA||Wang, Tiancheng,et al."Urinary Prostate-Specific Antigen is Elevated in Female Patients with Cushing′s Syndrome".LABMEDICINE 42.2(2011):102-105.|