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Quercetin and quercitrin protect against cytokine-induced injuries in RINm5F beta-cells via the mitochondrial pathway and NF-kappa B signaling
Dai, Xiaoqian; Ding, Ye; Zhang, Zhaofeng; Cai, Xiaxia; Li, Yong
关键词Inflammation Insulin Producing Beta-cells Mitochondrial Apoptosis Quercetin Quercitrin
刊名INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
2013
DOI10.3892/ijmm.2012.1177
31期:1页:265-271
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental
研究领域[WOS]Research & Experimental Medicine
关键词[WOS]PRO-INFLAMMATORY CYTOKINES ; INSULIN-PRODUCING CELLS ; INDUCED APOPTOSIS ; GENE-EXPRESSION ; DEATH ; ANTIOXIDANT ; DAMAGE ; HOMEOSTASIS ; INHIBITION ; ACTIVATION
英文摘要

Quercetin, existing mostly in its glycoside form quercitrin, is the most widely distributed flavonoid in nature. It possesses various potential effects as an antioxidant, anti-inflammatory for cell damage of beta-cells, however, studies on this topic are limited and controversial. In order to examine the effects of quercetin on type I diabetes mellitus, we investigated the role of quercetin/quercitrin in cytokine-induced beta-cell injuries in RINm5F rat insulinoma cells. Cell viability, glucose-stimulated insulin secretion (GSIS), intracellular reactive oxygen species (ROS), nitric oxide (NO) and inflammation or apoptosis-associated protein expression were measured with or without quercetin/quercitrin treatment. We also compared the differences between the aglycone and the glycoside forms of quercetin, with the aim to shed some light on their structures and transportation into cells. The results showed that quercetin/quercitrin protected against cytokine-induced cell death, improved GSIS, and inhibited ROS as well as NO accumulation. These effects were associated with reduced expression of inducible nitric oxide synthases (iNOS) and inhibited translocation of nuclear factor-kappa B (NF-kappa B). Also, quercetin/quercitrin suppressed cytochrome c release from mitochondria and the following alteration of downstream proteins, suggesting that mitochondrial apoptosis was attenuated by quercetin treatment. In summary, quercetin and quercitrin are potential candidates to prevent beta-cell death via the mitochondrial pathway and NF-kappa B signaling, and quercetin may be more efficacious than quercitrin as an anti-diabetic agent.

语种英语
WOS记录号WOS:000312567000034
项目编号H2603/81172652
资助机构National Natural Science Foundation of China (NSFC)
引用统计
被引频次:29[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56108
专题北京大学公共卫生学院
北京大学公共卫生学院_营养与食品卫生学系
作者单位Peking Univ, Hlth Sci Ctr, Dept Nutr & Food Hyg, Sch Publ Hlth, Beijing 100191, Peoples R China
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GB/T 7714
Dai, Xiaoqian,Ding, Ye,Zhang, Zhaofeng,et al. Quercetin and quercitrin protect against cytokine-induced injuries in RINm5F beta-cells via the mitochondrial pathway and NF-kappa B signaling[J]. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE,2013,31(1):265-271.
APA Dai, Xiaoqian,Ding, Ye,Zhang, Zhaofeng,Cai, Xiaxia,&Li, Yong.(2013).Quercetin and quercitrin protect against cytokine-induced injuries in RINm5F beta-cells via the mitochondrial pathway and NF-kappa B signaling.INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE,31(1),265-271.
MLA Dai, Xiaoqian,et al."Quercetin and quercitrin protect against cytokine-induced injuries in RINm5F beta-cells via the mitochondrial pathway and NF-kappa B signaling".INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 31.1(2013):265-271.
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