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学科主题: 公共卫生
题名:
Quercetin and quercitrin protect against cytokine-induced injuries in RINm5F beta-cells via the mitochondrial pathway and NF-kappa B signaling
作者: Dai, Xiaoqian; Ding, Ye; Zhang, Zhaofeng; Cai, Xiaxia; Li, Yong
关键词: inflammation ; insulin producing beta-cells ; mitochondrial apoptosis ; quercetin ; quercitrin
刊名: INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
发表日期: 2013
DOI: 10.3892/ijmm.2012.1177
卷: 31, 期:1, 页:265-271
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental
研究领域[WOS]: Research & Experimental Medicine
关键词[WOS]: PRO-INFLAMMATORY CYTOKINES ; INSULIN-PRODUCING CELLS ; INDUCED APOPTOSIS ; GENE-EXPRESSION ; DEATH ; ANTIOXIDANT ; DAMAGE ; HOMEOSTASIS ; INHIBITION ; ACTIVATION
英文摘要:

Quercetin, existing mostly in its glycoside form quercitrin, is the most widely distributed flavonoid in nature. It possesses various potential effects as an antioxidant, anti-inflammatory for cell damage of beta-cells, however, studies on this topic are limited and controversial. In order to examine the effects of quercetin on type I diabetes mellitus, we investigated the role of quercetin/quercitrin in cytokine-induced beta-cell injuries in RINm5F rat insulinoma cells. Cell viability, glucose-stimulated insulin secretion (GSIS), intracellular reactive oxygen species (ROS), nitric oxide (NO) and inflammation or apoptosis-associated protein expression were measured with or without quercetin/quercitrin treatment. We also compared the differences between the aglycone and the glycoside forms of quercetin, with the aim to shed some light on their structures and transportation into cells. The results showed that quercetin/quercitrin protected against cytokine-induced cell death, improved GSIS, and inhibited ROS as well as NO accumulation. These effects were associated with reduced expression of inducible nitric oxide synthases (iNOS) and inhibited translocation of nuclear factor-kappa B (NF-kappa B). Also, quercetin/quercitrin suppressed cytochrome c release from mitochondria and the following alteration of downstream proteins, suggesting that mitochondrial apoptosis was attenuated by quercetin treatment. In summary, quercetin and quercitrin are potential candidates to prevent beta-cell death via the mitochondrial pathway and NF-kappa B signaling, and quercetin may be more efficacious than quercitrin as an anti-diabetic agent.

语种: 英语
所属项目编号: H2603/81172652
项目资助者: National Natural Science Foundation of China (NSFC)
WOS记录号: WOS:000312567000034
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56108
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: Peking Univ, Hlth Sci Ctr, Dept Nutr & Food Hyg, Sch Publ Hlth, Beijing 100191, Peoples R China

Recommended Citation:
Dai, Xiaoqian,Ding, Ye,Zhang, Zhaofeng,et al. Quercetin and quercitrin protect against cytokine-induced injuries in RINm5F beta-cells via the mitochondrial pathway and NF-kappa B signaling[J]. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE,2013,31(1):265-271.
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