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Apoptin induces chromatin condensation in normal cells
He, XJ; Zhang, Q; Liu, YJ; He, PY
关键词adenovirus vector chromatin condensation Apoptin G(2)-M arrest
刊名VIRUS GENES
2005-08-01
DOI10.1007/s11262-005-2200-4
31期:1页:49-55
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Genetics & Heredity ; Virology
研究领域[WOS]Genetics & Heredity ; Virology
关键词[WOS]CHICKEN ANEMIA VIRUS ; PROTEIN APOPTIN ; CYCLE ARREST ; NUCLEAR-LOCALIZATION ; TUMOR-CELLS ; G(2) PHASE ; APOPTOSIS ; INDIVIDUALS ; INDUCTION ; INFECTION
英文摘要

Apoptin, a chicken anemia virus protein, was reported to induce tumor specific apoptosis, which was correlated with the nuclear localization of the protein in tumor cells. While in normal human cells, Apoptin was detected mainly in the cytoplasm and did not induce apoptosis. Using a recombinant adenovirus expressing Apoptin, we have found that Apoptin induced G(2)-M cell cycle arrest and chromatin condensation in cancer cells. Here we report that adenovirus mediated Apoptin expression also induces G(2)-M arrest in normal cells. In normal cells Apoptin is localized mainly in the cytoplasm but is also found in the nucleus of a subset of cells. Apoptin induces chromatin condensation not only when it is expressed in the nucleus but also when it is expressed in the cytoplasm. Our results indicate that Apoptin-induced chromatin condensation in the normal cells may not correlate with its nuclear localization and the mechanism of regulating the G(2)-M transition might be a target for Apoptin.

语种英语
WOS记录号WOS:000229908000006
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被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56117
专题北京大学第二临床医学院_中心实验室
作者单位Peking Univ, Peoples Hosp, Cent Lab, Beijing 100044, Peoples R China
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GB/T 7714
He, XJ,Zhang, Q,Liu, YJ,et al. Apoptin induces chromatin condensation in normal cells[J]. VIRUS GENES,2005,31(1):49-55.
APA He, XJ,Zhang, Q,Liu, YJ,&He, PY.(2005).Apoptin induces chromatin condensation in normal cells.VIRUS GENES,31(1),49-55.
MLA He, XJ,et al."Apoptin induces chromatin condensation in normal cells".VIRUS GENES 31.1(2005):49-55.
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