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学科主题: 临床医学
题名:
Apoptin induces chromatin condensation in normal cells
作者: He, XJ; Zhang, Q; Liu, YJ; He, PY
关键词: adenovirus vector ; chromatin condensation ; Apoptin ; G(2)-M arrest
刊名: VIRUS GENES
发表日期: 2005-08-01
DOI: 10.1007/s11262-005-2200-4
卷: 31, 期:1, 页:49-55
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Genetics & Heredity ; Virology
研究领域[WOS]: Genetics & Heredity ; Virology
关键词[WOS]: CHICKEN ANEMIA VIRUS ; PROTEIN APOPTIN ; CYCLE ARREST ; NUCLEAR-LOCALIZATION ; TUMOR-CELLS ; G(2) PHASE ; APOPTOSIS ; INDIVIDUALS ; INDUCTION ; INFECTION
英文摘要:

Apoptin, a chicken anemia virus protein, was reported to induce tumor specific apoptosis, which was correlated with the nuclear localization of the protein in tumor cells. While in normal human cells, Apoptin was detected mainly in the cytoplasm and did not induce apoptosis. Using a recombinant adenovirus expressing Apoptin, we have found that Apoptin induced G(2)-M cell cycle arrest and chromatin condensation in cancer cells. Here we report that adenovirus mediated Apoptin expression also induces G(2)-M arrest in normal cells. In normal cells Apoptin is localized mainly in the cytoplasm but is also found in the nucleus of a subset of cells. Apoptin induces chromatin condensation not only when it is expressed in the nucleus but also when it is expressed in the cytoplasm. Our results indicate that Apoptin-induced chromatin condensation in the normal cells may not correlate with its nuclear localization and the mechanism of regulating the G(2)-M transition might be a target for Apoptin.

语种: 英语
WOS记录号: WOS:000229908000006
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56117
Appears in Collections:北京大学第二临床医学院_中心实验室_期刊论文

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作者单位: Peking Univ, Peoples Hosp, Cent Lab, Beijing 100044, Peoples R China

Recommended Citation:
He, XJ,Zhang, Q,Liu, YJ,et al. Apoptin induces chromatin condensation in normal cells[J]. VIRUS GENES,2005,31(1):49-55.
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