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学科主题: 临床医学
题名:
Immunoscintigraphy of local recurrent rectal cancer with 9(9m)Tc-labeled anti-CEA monoclonal antibody CL58
作者: Yao, Yun-Feng; Yang, Zhi; Li, Zhen-Fu; Gu, Jin
关键词: immunoscintigraphy ; rectal cancer ; recurrence ; monoclonal antibody
刊名: WORLD JOURNAL OF GASTROENTEROLOGY
发表日期: 2007-03-28
卷: 13, 期:12, 页:1841-1846
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
关键词[WOS]: TOTAL MESORECTAL EXCISION ; CARCINOEMBRYONIC ANTIGEN ; COLORECTAL-CANCER ; CARCINOMA ; DIAGNOSIS ; SURGERY ; SCINTIGRAPHY ; TOMOGRAPHY ; EXPERIENCE
英文摘要:

AIM: To explore a specific diagnostic method for local recurrent rectal cancer.

METHODS: Immunoscintigraphy with Tc-99m-labeled anti-CEA monoclonal antibody (MoAb) CL-58 was performed for patients suspected of having a postoperative local recurrent rectal cancer and the findings were compared with the results of conventional imaging and pathology.

RESULTS: A total of 36 patients with a suspected local recurrent rectal cancer underwent immunoscintigraphy with Tc-99m-conjugated CL58. Local recurrence of rectal cancer was identified in 31 patients and established in 30 during operation, endoscopy and pathological examination. No local recurrence was found in 5 patients without specific accumulation of Tc-99m during the follow-up. Immunoscintigraphy had a positive rate of 86.11%, a specificity of 83.33%, and a sensitivity of 100%.

CONCLUSION: Immunoscintigraphy has a highly specific and predictive value for detecting local recurrent rectal cancer, especially after abdominal perineal resection (APR).

(C) 2007 The WJG Press. All rights reserved.

语种: 英语
WOS记录号: WOS:000246090000014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56125
Appears in Collections:北京大学临床肿瘤学院_期刊论文

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作者单位: Peking Univ, Sch Oncol, Beijing 100036, Peoples R China

Recommended Citation:
Yao, Yun-Feng,Yang, Zhi,Li, Zhen-Fu,et al. Immunoscintigraphy of local recurrent rectal cancer with 9(9m)Tc-labeled anti-CEA monoclonal antibody CL58[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2007,13(12):1841-1846.
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