北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第三临床医学院  > 期刊论文
学科主题: 临床医学
题名:
Association of CYP3A4*18B polymorphisms with the pharmacokinetics of cyclosporine in healthy subjects
作者: Hu, Y.-F.; Tu, J.-H.; Tan, Z.-R.; Liu, Z.-Q.; Zhou, G.; He, J.; Wang, D.; Zhou, H.-H.
关键词: CYP3A4 ; polymorphisms ; cyclosporine ; pharmacokinetics
刊名: XENOBIOTICA
发表日期: 2007-03-01
DOI: 10.1080/00498250601149206
卷: 37, 期:3, 页:315-327
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy ; Toxicology
研究领域[WOS]: Pharmacology & Pharmacy ; Toxicology
关键词[WOS]: HUMAN-LIVER ; CYP3A4 ; IDENTIFICATION ; CHINESE ; CYTOCHROME-P-450 ; METABOLISM ; REJECTION ; CYP2C19 ; PHARMACOGENOMICS ; INHIBITORS
英文摘要:

The aim of this study is to evaluate the association of the CYP3A4(*) 18B genotype with the cyclosporine metabolism in healthy subjects. We employed PCR RFLP assays for analysis of the CYP3A4(*)18B genotype. Each of 26 subjects, comprising 12 CYP3A4(*)1/(*)l, 12 CYP3A4(*)1/(*)18B and 2 CYP3A4(*)18B/(*)18B, was given a single oral dose of cyclosporine (4mgkg(-1)). The plasma concentrations of cyclosporine were measured for up to 24h post dose by high-performance liquid chromatography-electrospray mass spectrometry. We found that the mean C-max (95% confidence intervals) of cyclosporine were 2237 (2905, 1859) ((*)1/(*)1), 2247 (2916, 1869) ((*)1/(*)18B), and 905 (1192,506) ngml(-1) ((*)18B/(*1)8B)(p=0.037) and the mean AUCO-4were 5026 (6181, 4372) ((*)1/(*)1), 4434 (5481, 3841) ((*)1/(*)18B) and 2561 (3155, 1736) ng ml-1 h ((*)18B/(*)18B)(p=0.02l). The CL in the (*)18B/(*)18B group was significantly higher than in the (*)1/(*)1 group. However, T-maz exhibited no difference among the three genotypes. (*)18B/(*)18B group showed 50% reduction in concentration at 2h post dose compared with (*)1/(*)18B (p=0.062) or (*)1/(*)1 (p=0.047), but no statistical significance was detected between *1/(*)1 and *1/*18B groups (p > 0.05). The data suggest that the CYP3A4(*)18B genotype affects cyclosporine pharmacokinetics probably resulting from a higher enzymatic activity of this mutation in healthy subjects.

语种: 英语
WOS记录号: WOS:000245984500007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56128
Appears in Collections:北京大学第三临床医学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Cent S Univ, Inst Clin Pharmacol, Pharmacogenet Res Inst, Changsha 410078, Hunan, Peoples R China
2.Peking Univ, Hosp 3, Beijing 100871, Peoples R China

Recommended Citation:
Hu, Y.-F.,Tu, J.-H.,Tan, Z.-R.,et al. Association of CYP3A4*18B polymorphisms with the pharmacokinetics of cyclosporine in healthy subjects[J]. XENOBIOTICA,2007,37(3):315-327.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Hu, Y.-F.]'s Articles
[Tu, J.-H.]'s Articles
[Tan, Z.-R.]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Hu, Y.-F.]‘s Articles
[Tu, J.-H.]‘s Articles
[Tan, Z.-R.]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace