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Amplitude of low frequency fluctuation within visual areas revealed by resting-state functional MRI
Yang, Hong; Long, Xiang-Yu; Yang, Yihong; Yan, Hao; Zhu, Chao-Zhe; Zhou, Xiang-Ping; Zang, Yu-Feng; Gong, Qi-Yong
刊名NEUROIMAGE
2007-05-15
DOI10.1016/j.neuroimage.2007.01.054
36期:1页:144-152
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]DEFAULT-MODE ; MAGNETIC-RESONANCE ; BRAIN-FUNCTION ; MOTOR CORTEX ; ALPHA-RHYTHM ; BOLD SIGNAL ; CONNECTIVITY ; FMRI ; ACTIVATION ; HYPOTHESIS
英文摘要

Most studies of resting-state functional magnetic resonance imaging (fMRI) have applied the temporal correlation in the time courses to investigate the functional connectivity between brain regions. Alternatively, the power of low frequency fluctuation (LFF) may also be used as a biomarker to assess spontaneous activity. The purpose of the current study is to evaluate whether the amplitude of the LFF (ALFF) relates to cerebral physiological states. Ten healthy subjects underwent four resting-state fMRI scanning sessions, two for eyes-open (EO) and two for eyes-closed (EC) conditions, with two sets of parameters (TR=400 ms and 2 s, respectively). After data preprocessing, ALFF was obtained by calculating the square root of the power spectrum in the frequency range of 0.01-0.08 Hz. Our results showed that the ALFF in EO was significantly higher than that in EC (P<0.05, corrected) in the bilateral visual cortices. Furthermore, the ALFF in EO was significantly reduced in the right paracentral lobule (PCL) than in EC (P<0.05, corrected). Region of interest (ROI) analysis showed that the ALFF differences between EO and EC were consistent for each subject. In contrast, no significant ALFF differences were found between EO and EC (P<0.381) in the posterior cingulate cortex. All these results agree well with previous studies comparing EO and EC states. Our finding of the distinct ALFF difference between EO and EC in the visual cortex implies that the ALFF may be a novel biomarker for physiological states of the brain. (C) 2007 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000246559500014
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被引频次:212[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56132
专题北京大学精神卫生研究所
作者单位1.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China
2.Sichuan Univ, W China Hosp, Dept Radiol, HMRRC, Chengdu, Peoples R China
3.NIDA, Neuroimaging Res Branch, NIH, Baltimore, MD 21042 USA
4.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China
5.Univ Liverpool, Fac Med, Div Med Imaging, Liverpool L69 3GB, Merseyside, England
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Yang, Hong,Long, Xiang-Yu,Yang, Yihong,et al. Amplitude of low frequency fluctuation within visual areas revealed by resting-state functional MRI[J]. NEUROIMAGE,2007,36(1):144-152.
APA Yang, Hong.,Long, Xiang-Yu.,Yang, Yihong.,Yan, Hao.,Zhu, Chao-Zhe.,...&Gong, Qi-Yong.(2007).Amplitude of low frequency fluctuation within visual areas revealed by resting-state functional MRI.NEUROIMAGE,36(1),144-152.
MLA Yang, Hong,et al."Amplitude of low frequency fluctuation within visual areas revealed by resting-state functional MRI".NEUROIMAGE 36.1(2007):144-152.
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