IR@PKUHSC  > 北京大学第一临床医学院  > 皮肤性病科
学科主题临床医学
A Promoter Region Polymorphism in PDCD-1 Gene Is Associated with Risk of Rheumatoid Arthritis in the Han Chinese Population of Southeastern China
Liu, CuiPing1; Jiang, JueAn1; Gao, Li2,3; Hu, XiaoHan2; Wang, FengMing4; Shen, Yu1; Yu, GeHua2; Zhao, ZuoTao5; Zhang, XueGuang1
刊名INTERNATIONAL JOURNAL OF GENOMICS
2014
DOI10.1155/2014/247637
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Genetics & Heredity
研究领域[WOS]Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Genetics & Heredity
关键词[WOS]SYSTEMIC-LUPUS-ERYTHEMATOSUS ; T-CELL TOLERANCE ; PD-1 GENE ; REGULATORY POLYMORPHISM ; PATHWAY ; SUSCEPTIBILITY ; AUTOIMMUNITY ; MECHANISMS ; HAPLOTYPE ; LIGANDS
英文摘要

Objective. Programmed cell death 1 (PD-1) induces negative signals to T cells during interaction with its ligands and is therefore a candidate gene in the development of autoimmune diseases such as rheumatoid arthritis (RA). Herein, we investigate the association of PDCD-1 polymorphisms with the risk of RA among Chinese patients and healthy controls. Methods. Using the PCR-direct sequencing analysis, 4 PDCD-1 SNPs (rs36084323, rs11568821, rs2227982, and rs2227981) were genotyped in 320 RA patients and 309 matched healthy controls. Expression of PD-1 was determined in peripheral blood lymphocytes by flow cytometry and quantitative real-time reverse transcriptase polymerase chain reaction. Results. We observed that the GG genotype of rs36084323 was associated with a increased risk for developing RA (OR 1.70, 95% 1.11-2.61, P = 0.049). Patients carrying G/G genotype displayed an increased mRNA level of PD-1 (P = 0.04) compared with A/A genotype and healthy controls. Meanwhile, patients homozygous for rs36084323 had induced basal PD-1 expression on activated CD4+ T cells. Conclusion. The PDCD-1 polymorphism rs36084323 was significantly associated with RA risk in Han Chinese population. This SNP, which effectively influenced the expression of PD-1, may be a biomarker of early diagnosis of RA and a suitable indicator of utilizing PD-1 inhibitor for treatment of RA.

语种英语
WOS记录号WOS:000334200200001
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被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56136
专题北京大学第一临床医学院_皮肤性病科
作者单位1.Wuxi Red Cross Blood Ctr, Wuxi 214021, Peoples R China
2.Soochow Univ, Affiliated Hosp 1, Jiangsu Inst Clin Immunol, Suzhou 215006, Peoples R China
3.Soochow Univ, Med Biotechnol Inst, Suzhou 215006, Peoples R China
4.Ctr Dis Control & Prevent, Testing Ctr, Changzhou 213000, Peoples R China
5.Peking Univ, Hosp 1, Dept Dermatol, Beijing 100034, Peoples R China
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Liu, CuiPing,Jiang, JueAn,Gao, Li,et al. A Promoter Region Polymorphism in PDCD-1 Gene Is Associated with Risk of Rheumatoid Arthritis in the Han Chinese Population of Southeastern China[J]. INTERNATIONAL JOURNAL OF GENOMICS,2014.
APA Liu, CuiPing.,Jiang, JueAn.,Gao, Li.,Hu, XiaoHan.,Wang, FengMing.,...&Zhang, XueGuang.(2014).A Promoter Region Polymorphism in PDCD-1 Gene Is Associated with Risk of Rheumatoid Arthritis in the Han Chinese Population of Southeastern China.INTERNATIONAL JOURNAL OF GENOMICS.
MLA Liu, CuiPing,et al."A Promoter Region Polymorphism in PDCD-1 Gene Is Associated with Risk of Rheumatoid Arthritis in the Han Chinese Population of Southeastern China".INTERNATIONAL JOURNAL OF GENOMICS (2014).
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