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学科主题: 临床医学
题名:
A Promoter Region Polymorphism in PDCD-1 Gene Is Associated with Risk of Rheumatoid Arthritis in the Han Chinese Population of Southeastern China
作者: Liu, CuiPing1; Jiang, JueAn1; Gao, Li2,3; Hu, XiaoHan2; Wang, FengMing4; Shen, Yu1; Yu, GeHua2; Zhao, ZuoTao5; Zhang, XueGuang1
刊名: INTERNATIONAL JOURNAL OF GENOMICS
发表日期: 2014
DOI: 10.1155/2014/247637
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Genetics & Heredity
研究领域[WOS]: Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Genetics & Heredity
关键词[WOS]: SYSTEMIC-LUPUS-ERYTHEMATOSUS ; T-CELL TOLERANCE ; PD-1 GENE ; REGULATORY POLYMORPHISM ; PATHWAY ; SUSCEPTIBILITY ; AUTOIMMUNITY ; MECHANISMS ; HAPLOTYPE ; LIGANDS
英文摘要:

Objective. Programmed cell death 1 (PD-1) induces negative signals to T cells during interaction with its ligands and is therefore a candidate gene in the development of autoimmune diseases such as rheumatoid arthritis (RA). Herein, we investigate the association of PDCD-1 polymorphisms with the risk of RA among Chinese patients and healthy controls. Methods. Using the PCR-direct sequencing analysis, 4 PDCD-1 SNPs (rs36084323, rs11568821, rs2227982, and rs2227981) were genotyped in 320 RA patients and 309 matched healthy controls. Expression of PD-1 was determined in peripheral blood lymphocytes by flow cytometry and quantitative real-time reverse transcriptase polymerase chain reaction. Results. We observed that the GG genotype of rs36084323 was associated with a increased risk for developing RA (OR 1.70, 95% 1.11-2.61, P = 0.049). Patients carrying G/G genotype displayed an increased mRNA level of PD-1 (P = 0.04) compared with A/A genotype and healthy controls. Meanwhile, patients homozygous for rs36084323 had induced basal PD-1 expression on activated CD4+ T cells. Conclusion. The PDCD-1 polymorphism rs36084323 was significantly associated with RA risk in Han Chinese population. This SNP, which effectively influenced the expression of PD-1, may be a biomarker of early diagnosis of RA and a suitable indicator of utilizing PD-1 inhibitor for treatment of RA.

语种: 英语
所属项目编号: 2013CB53051 ; 31170834 ; 30930085 ; SYS201331
项目资助者: National Basic Research Development Program of China (973 program) ; National Natural Science Foundation of China ; Science and Technology Project of Suzhou
WOS记录号: WOS:000334200200001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56136
Appears in Collections:北京大学第一临床医学院_皮肤性病科_期刊论文

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作者单位: 1.Wuxi Red Cross Blood Ctr, Wuxi 214021, Peoples R China
2.Soochow Univ, Affiliated Hosp 1, Jiangsu Inst Clin Immunol, Suzhou 215006, Peoples R China
3.Soochow Univ, Med Biotechnol Inst, Suzhou 215006, Peoples R China
4.Ctr Dis Control & Prevent, Testing Ctr, Changzhou 213000, Peoples R China
5.Peking Univ, Hosp 1, Dept Dermatol, Beijing 100034, Peoples R China

Recommended Citation:
Liu, CuiPing,Jiang, JueAn,Gao, Li,et al. A Promoter Region Polymorphism in PDCD-1 Gene Is Associated with Risk of Rheumatoid Arthritis in the Han Chinese Population of Southeastern China[J]. INTERNATIONAL JOURNAL OF GENOMICS,2014.
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