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学科主题: 临床医学
题名:
Experimental Research on the In Vitro Antitumor Effects of Crataegus sanguinea
作者: Sun, Jianling1; Gao, Guolan2; Gao, YuLian2; Xiong, LiJuan2; Li, Xiaoying3; Guo, Jihong4; Zhang, Yueming5
关键词: Crataegus sanguinea ; Tumor cell ; Anti-mutagenic ; Antitumor
刊名: CELL BIOCHEMISTRY AND BIOPHYSICS
发表日期: 2013-09-01
DOI: 10.1007/s12013-013-9535-6
卷: 67, 期:1, 页:207-213
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
关键词[WOS]: CYCLE ARREST ; CANCER ; EXTRACT ; DISEASE ; CELLS ; RISK
英文摘要:

Crataegus sanguinea is a wild plant, which has been widely grown in the north and south of the Tianshan mountains in Xinjiang. In order to explore their anti-cancer properties, edible wild plants from Xinjiang have been tested for their antitumor properties. We used Ames tests, mouse bone marrow polychromatic erythrocytes micronucleus tests, and tumor cells cultured in vitro to study the anti-mutagenic and anti-tumor effects of C. sanguinea extract. We have shown that C. sanguinea has anti-mutagenic effect, but no mutagenicity. Cell culture in vitro experiments show that there is no inhibition of growth or increase in cell death on normal mouse fibroblasts, but a stronger inhibition of cell growth and an increase in cell death of Hep-2 and MGC-803 tumor cells. The results of this study illustrate that C. sanguinea extract has both anti-mutagenic and anti-tumor effects.

语种: 英语
WOS记录号: WOS:000323663300022
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56147
Appears in Collections:北京大学第二临床医学院_心血管内科_期刊论文

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作者单位: 1.Aviat Gen Hosp, Dept Cardiol, Beijing 100012, Peoples R China
2.Aviat Gen Hosp, Dept Gynecol & Oncol, Beijing 100012, Peoples R China
3.Chinese Peoples Liberat Army Gen Hosp, Dept Geriatr Cardiol, Beijing 100853, Peoples R China
4.Peking Univ, Peoples Hosp, Dept Cardiol, Electrophysiol Grp, Beijing 100044, Peoples R China
5.XinJiang Med Univ, Dept Nutr & Food Hyg, Urumqi 830054, Peoples R China

Recommended Citation:
Sun, Jianling,Gao, Guolan,Gao, YuLian,et al. Experimental Research on the In Vitro Antitumor Effects of Crataegus sanguinea[J]. CELL BIOCHEMISTRY AND BIOPHYSICS,2013,67(1):207-213.
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