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学科主题临床医学
Experimental Research on the In Vitro Antitumor Effects of Crataegus sanguinea
Sun, Jianling1; Gao, Guolan2; Gao, YuLian2; Xiong, LiJuan2; Li, Xiaoying3; Guo, Jihong4; Zhang, Yueming5
关键词Crataegus Sanguinea Tumor Cell Anti-mutagenic Antitumor
刊名CELL BIOCHEMISTRY AND BIOPHYSICS
2013-09-01
DOI10.1007/s12013-013-9535-6
67期:1页:207-213
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
关键词[WOS]CYCLE ARREST ; CANCER ; EXTRACT ; DISEASE ; CELLS ; RISK
英文摘要

Crataegus sanguinea is a wild plant, which has been widely grown in the north and south of the Tianshan mountains in Xinjiang. In order to explore their anti-cancer properties, edible wild plants from Xinjiang have been tested for their antitumor properties. We used Ames tests, mouse bone marrow polychromatic erythrocytes micronucleus tests, and tumor cells cultured in vitro to study the anti-mutagenic and anti-tumor effects of C. sanguinea extract. We have shown that C. sanguinea has anti-mutagenic effect, but no mutagenicity. Cell culture in vitro experiments show that there is no inhibition of growth or increase in cell death on normal mouse fibroblasts, but a stronger inhibition of cell growth and an increase in cell death of Hep-2 and MGC-803 tumor cells. The results of this study illustrate that C. sanguinea extract has both anti-mutagenic and anti-tumor effects.

语种英语
WOS记录号WOS:000323663300022
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56147
专题北京大学第二临床医学院_心血管内科
北京大学临床肿瘤学院_药剂科
作者单位1.Aviat Gen Hosp, Dept Cardiol, Beijing 100012, Peoples R China
2.Aviat Gen Hosp, Dept Gynecol & Oncol, Beijing 100012, Peoples R China
3.Chinese Peoples Liberat Army Gen Hosp, Dept Geriatr Cardiol, Beijing 100853, Peoples R China
4.Peking Univ, Peoples Hosp, Dept Cardiol, Electrophysiol Grp, Beijing 100044, Peoples R China
5.XinJiang Med Univ, Dept Nutr & Food Hyg, Urumqi 830054, Peoples R China
推荐引用方式
GB/T 7714
Sun, Jianling,Gao, Guolan,Gao, YuLian,et al. Experimental Research on the In Vitro Antitumor Effects of Crataegus sanguinea[J]. CELL BIOCHEMISTRY AND BIOPHYSICS,2013,67(1):207-213.
APA Sun, Jianling.,Gao, Guolan.,Gao, YuLian.,Xiong, LiJuan.,Li, Xiaoying.,...&Zhang, Yueming.(2013).Experimental Research on the In Vitro Antitumor Effects of Crataegus sanguinea.CELL BIOCHEMISTRY AND BIOPHYSICS,67(1),207-213.
MLA Sun, Jianling,et al."Experimental Research on the In Vitro Antitumor Effects of Crataegus sanguinea".CELL BIOCHEMISTRY AND BIOPHYSICS 67.1(2013):207-213.
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