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学科主题: 基础医学
题名:
Investigation of hepatic fibrosis in rats with x-ray diffraction enhanced imaging
作者: Li, Hui1,2; Zhang, Lu1; Wang, Xueyan1; Wang, Tailing3; Wang, Baoen4; Zhao, Xinyan4; Luo, Shuqian1
关键词: biological tissues ; diagnostic radiography ; image enhancement ; liver ; medical image processing ; X-ray diffraction
刊名: APPLIED PHYSICS LETTERS
发表日期: 2009-03-23
DOI: 10.1063/1.3104860
卷: 94, 期:12
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Physics, Applied
研究领域[WOS]: Physics
关键词[WOS]: LIVER FIBROSIS
英文摘要:

X-ray diffraction enhanced imaging (DEI) is a phase contrast technique that generates excellent contrast of biological soft tissues compared to conventional absorption radiography. We explore the application of DEI in the diagnosis of hepatic fibrosis. The produced refraction contrast images of fibrous rat liver samples show clearly abnormal liver architectures. Moreover, by comparing to histological pictures, different stages of fibrosis are discriminated, and the corresponding morphological features are analyzed. Besides, quantitative analyses of texture features are presented. The results reported herein show that DEI can be a potential noninvasive technique to diagnose and stage hepatic fibrosis.

语种: 英语
所属项目编号: 60532090 ; 30770593
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000264633500078
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56160
Appears in Collections:基础医学院_生物物理学系_期刊论文

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作者单位: 1.Capital Med Univ, Sch Biomed Engn, Beijing 100069, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Med Phys, Beijing 100191, Peoples R China
3.China Japan Friendship Hosp, Dept Pathol, Beijing 100029, Peoples R China
4.Beijing Friendship Hosp, Liver Res Ctr, Beijing 100050, Peoples R China

Recommended Citation:
Li, Hui,Zhang, Lu,Wang, Xueyan,et al. Investigation of hepatic fibrosis in rats with x-ray diffraction enhanced imaging[J]. APPLIED PHYSICS LETTERS,2009,94(12).
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