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学科主题: 药学
题名:
Ligand-Promoted Pd-Catalyzed Oxime Ether Directed C-H Hydroxylation of Arenes
作者: Liang, Yu-Feng1; Wang, Xiaoyang1; Yuan, Yizhi1; Liang, Yujie1; Li, Xinyao1; Jiao, Ning1,2
关键词: hydroxylation ; C-H functionalization ; palladium ; oxygenation ; chemoselectivity
刊名: ACS CATALYSIS
发表日期: 2015-10-01
DOI: 10.1021/acscatal.5b01700
卷: 5, 期:10, 页:6148-6152
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Physical
研究领域[WOS]: Chemistry
关键词[WOS]: REGIOSELECTIVE ORTHO-HYDROXYLATION ; BOND OXYGENATION ; SINGLET-OXYGEN ; ACTIVATION ; OXIDATION ; RUTHENIUM ; FUNCTIONALIZATION ; EFFICIENT ; KETONES ; ALCOHOLS
英文摘要:

An efficient Pd-catalyzed oxime ether directed ortho C-H hydroxylation of arenes under neutral conditions has been developed. The efficiency of this hydroxylation is significantly improved by a ligand. Oxone, an inexpensive, readily available, and safe reagent, was employed as terminal oxidant and oxygen source. The challenging electron-deficient substrates could also be monohydroxylated in high efficiency. Drug modification with this protocol was also successfully demonstrated.

语种: 英语
所属项目编号: 2015CB856600 ; 21325206 ; 21172006
项目资助者: National Basic Research Program of China (973 Program) ; National Natural Science Foundation of China ; National Young Top-notch Talent Support Program
WOS记录号: WOS:000362391500051
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56161
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Chinese Acad Sci, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

Recommended Citation:
Liang, Yu-Feng,Wang, Xiaoyang,Yuan, Yizhi,et al. Ligand-Promoted Pd-Catalyzed Oxime Ether Directed C-H Hydroxylation of Arenes[J]. ACS CATALYSIS,2015,5(10):6148-6152.
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