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学科主题药学
Ligand-Promoted Pd-Catalyzed Oxime Ether Directed C-H Hydroxylation of Arenes
Liang, Yu-Feng1; Wang, Xiaoyang1; Yuan, Yizhi1; Liang, Yujie1; Li, Xinyao1; Jiao, Ning1,2
关键词Hydroxylation C-h Functionalization Palladium Oxygenation Chemoselectivity
刊名ACS CATALYSIS
2015-10-01
DOI10.1021/acscatal.5b01700
5期:10页:6148-6152
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Physical
资助者National Basic Research Program of China (973 Program) ; National Natural Science Foundation of China ; National Young Top-notch Talent Support Program ; National Basic Research Program of China (973 Program) ; National Natural Science Foundation of China ; National Young Top-notch Talent Support Program
研究领域[WOS]Chemistry
关键词[WOS]REGIOSELECTIVE ORTHO-HYDROXYLATION ; BOND OXYGENATION ; SINGLET-OXYGEN ; ACTIVATION ; OXIDATION ; RUTHENIUM ; FUNCTIONALIZATION ; EFFICIENT ; KETONES ; ALCOHOLS
英文摘要

An efficient Pd-catalyzed oxime ether directed ortho C-H hydroxylation of arenes under neutral conditions has been developed. The efficiency of this hydroxylation is significantly improved by a ligand. Oxone, an inexpensive, readily available, and safe reagent, was employed as terminal oxidant and oxygen source. The challenging electron-deficient substrates could also be monohydroxylated in high efficiency. Drug modification with this protocol was also successfully demonstrated.

语种英语
所属项目编号2015CB856600 ; 21325206 ; 21172006
资助者National Basic Research Program of China (973 Program) ; National Natural Science Foundation of China ; National Young Top-notch Talent Support Program ; National Basic Research Program of China (973 Program) ; National Natural Science Foundation of China ; National Young Top-notch Talent Support Program
WOS记录号WOS:000362391500051
Citation statistics
Cited Times:33[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56161
Collection北京大学药学院
作者单位1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Chinese Acad Sci, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China
Recommended Citation
GB/T 7714
Liang, Yu-Feng,Wang, Xiaoyang,Yuan, Yizhi,et al. Ligand-Promoted Pd-Catalyzed Oxime Ether Directed C-H Hydroxylation of Arenes[J]. ACS CATALYSIS,2015,5(10):6148-6152.
APA Liang, Yu-Feng,Wang, Xiaoyang,Yuan, Yizhi,Liang, Yujie,Li, Xinyao,&Jiao, Ning.(2015).Ligand-Promoted Pd-Catalyzed Oxime Ether Directed C-H Hydroxylation of Arenes.ACS CATALYSIS,5(10),6148-6152.
MLA Liang, Yu-Feng,et al."Ligand-Promoted Pd-Catalyzed Oxime Ether Directed C-H Hydroxylation of Arenes".ACS CATALYSIS 5.10(2015):6148-6152.
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