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学科主题临床医学
Advances in human antiglomerular basement membrane disease
Cui, Zhao; Zhao, Ming-Hui
刊名NATURE REVIEWS NEPHROLOGY
2011-12-01
DOI10.1038/nrneph.2011.89
7期:12页:697-705
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Urology & Nephrology
资助者Natural Science Fund of China ; Natural Science Fund of China
研究领域[WOS]Urology & Nephrology
关键词[WOS]ANTI-GBM ANTIBODIES ; EXPERIMENTAL AUTOIMMUNE GLOMERULONEPHRITIS ; NORMAL RENAL-FUNCTION ; T-CELL EPITOPE ; RAPIDLY PROGRESSIVE GLOMERULONEPHRITIS ; NORMAL HUMAN SERA ; IV COLLAGEN ; GOODPASTURE AUTOANTIGEN ; CRESCENTIC GLOMERULONEPHRITIS ; NATURAL AUTOANTIBODIES
英文摘要

Antiglomerular basement membrane (anti-GBM) disease is an autoimmune disorder that mostly presents as raised titers of antibodies against the GBM, rapidly progressive glomerulonephritis and pulmonary hemorrhage. The disease is caused by antibodies against noncollagenous domain of alpha 3 chain of type IV collagen, which contains the epitopes E(A) and E(B). The humoral and cellular immunity contributing to the initiation of anti-GBM disease has been extensively studied as a model for autoimmune diseases, although most of the data come from animal studies. The disease is rare, but diagnoses have been made in hundreds of patients. Substantial advances have been made in the understanding of human anti-GBM disease, and it can be treated successfully. In this Review we summarize the current knowledge on the prevalence, clinical manifestations, treatment and outcomes of human anti-GBM disease. We discuss findings on pathogenesis from human studies, with close attention to disease initiation and the immunological features of progression from quiescent autoimmune homeostasis in healthy individuals to fulminant anti-GBM disease. Further studies on autoreactive T cells are expected to clarify specific features of human anti-GBM disease and could lead to the development of new therapies.

语种英语
所属项目编号81021004
资助者Natural Science Fund of China ; Natural Science Fund of China
WOS记录号WOS:000297926800005
引用统计
被引频次:30[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56172
专题北京大学第一临床医学院_肾脏内科
作者单位Peking Univ, Hosp 1, Key Lab Renal Dis, Renal Div,Dept Med,Inst Nephrol,Minist Hlth China, Beijing 100034, Peoples R China
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Cui, Zhao,Zhao, Ming-Hui. Advances in human antiglomerular basement membrane disease[J]. NATURE REVIEWS NEPHROLOGY,2011,7(12):697-705.
APA Cui, Zhao,&Zhao, Ming-Hui.(2011).Advances in human antiglomerular basement membrane disease.NATURE REVIEWS NEPHROLOGY,7(12),697-705.
MLA Cui, Zhao,et al."Advances in human antiglomerular basement membrane disease".NATURE REVIEWS NEPHROLOGY 7.12(2011):697-705.
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