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学科主题: 基础医学
题名:
Comparison of Electroacupuncture in Restrained and Unrestrained Rat Models
作者: Zhang, Haolin1,2; Chen, Xiaolong1,2; Zhang, Chan1,2; Zhang, Ruixin3; Lao, Lixing3; Wan, You1,2,4; Yi, Ming1,2
刊名: EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
发表日期: 2013
DOI: 10.1155/2013/404956
期: 6
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Integrative & Complementary Medicine
研究领域[WOS]: Integrative & Complementary Medicine
关键词[WOS]: STIMULATION ; PAIN ; ACUPUNCTURE
英文摘要:

Acupuncture and electroacupuncture (EA) are widely used to treat a variety of diseases including pain. In preclinical research, EA is usually applied by inserting acupuncture needles into the hindlimbs of rats restrained in small tubes or bags. This restrained model of EA not only causes stress-like behaviors but also is limited in stimulating locations and intensities. In 2004, a novel, unrestrained model of EA was introduced. However, these two EA methods have never been directly compared regarding their analgesic effects and other features such as stress. In the present study, we reported similar analgesic effects between restrained and unrestrained EA in rats of acute inflammatory pain induced by intraplantar injection of CFA. In addition, rats receiving unrestrained EA showed less significant stress-like behaviors and tolerated higher current intensity. These advantages suggest that this unrestrained EA method can replace the traditional restrained procedure with similar analgesic effects and allow for more choices of stimulating intensities and locations.

语种: 英语
所属项目编号: 2013CB531905 ; 81221002 ; 31200835 ; BMU20120306
项目资助者: National Basic Research Program of China ; Ministry of Science and Technology ; Natural Science Foundation of China ; "111" program of the Ministry of Education of China ; Startup Grant for Young Researchers of Peking University
WOS记录号: WOS:000319572900001
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56176
Appears in Collections:基础医学院_神经生物学系_期刊论文

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作者单位: 1.Peking Univ, Neurosci Res Inst, Sch Basic Med Sci, Beijing 100191, Peoples R China
2.Peking Univ, Dept Neurobiol, Sch Basic Med Sci, Beijing 100191, Peoples R China
3.Univ Maryland, Sch Med, Ctr Integrat Med, Baltimore, MD 21201 USA
4.Peking Univ, Key Lab Neurosci, Minist Educ, Natl Hlth & Family Planning Commiss, Beijing 100191, Peoples R China

Recommended Citation:
Zhang, Haolin,Chen, Xiaolong,Zhang, Chan,et al. Comparison of Electroacupuncture in Restrained and Unrestrained Rat Models[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2013(6).
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