IR@PKUHSC  > 北京大学第一临床医学院
学科主题临床医学
Clinicopathological characteristics and outcomes of patients with crescentic lupus nephritis
Yu, Feng2; Tan, Ying2; Liu, Gang2; Wang, Su-xia2; Zou, Wan-zhong2; Zhao, Ming-hui1,2
关键词Anti-neutrophil Cytoplasmic Antibodies Crescentic Glomerulonephritis Lupus Nephritis
刊名KIDNEY INTERNATIONAL
2009-08-01
DOI10.1038/ki.2009.136
76期:3页:307-317
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Urology & Nephrology
研究领域[WOS]Urology & Nephrology
关键词[WOS]ANTINEUTROPHIL CYTOPLASMIC ANTIBODY ; MYCOPHENOLATE-MOFETIL ; INTRAVENOUS CYCLOPHOSPHAMIDE ; CHINESE PATIENTS ; TISSUE FACTOR ; GLOMERULONEPHRITIS ; ERYTHEMATOSUS ; AUTOANTIBODIES ; CLASSIFICATION ; EXPRESSION
英文摘要

There are few clinicopathologic and outcome data on patients with crescentic lupus nephritis, therefore, we determined factors of the disease by retrospectively reviewing the records of 327 patients diagnosed with lupus nephritis. Of these, 152 cases were regrouped as class IV-G, including 33 patients with crescentic glomerulonephritis. Significantly, all patients with crescentic glomerulonephritis had acute kidney injury as compared with only about a quarter of the patients without the disease. On pathological evaluation, activity scores, chronicity indexes, relapse rates, and the frequency of positive serum anti-neutrophil cytoplasmic antibody (ANCA) were each significantly higher, whereas complete remission rates and renal outcomes, over a mean follow-up of 4 years, were significantly poorer in patients with crescentic glomerulonephritis. Our study shows that crescentic glomerulonephritis was not rare in patients with lupus nephritis and that their long-term outcome was poor. The precise role of ANCA in the pathologic course of crescentic lupus nephritis remains to be determined. Kidney International (2009) 76, 307-317; doi:10.1038/ki.2009.136; published online 29 April 2009

语种英语
WOS记录号WOS:000267972800012
Citation statistics
Cited Times:50[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56180
Collection北京大学第一临床医学院
北京大学基础医学院
北京大学第一临床医学院_电镜室
北京大学第一临床医学院_肾脏内科
作者单位1.Peking Univ, Inst Nephrol, Beijing 100034, Peoples R China
2.Peking Univ, Peking Univ Hosp 1, Dept Med,Inst Nephrol, Key Lab Renal Dis,Minist Hlth China,Renal Div, Beijing 100034, Peoples R China
Recommended Citation
GB/T 7714
Yu, Feng,Tan, Ying,Liu, Gang,et al. Clinicopathological characteristics and outcomes of patients with crescentic lupus nephritis[J]. KIDNEY INTERNATIONAL,2009,76(3):307-317.
APA Yu, Feng,Tan, Ying,Liu, Gang,Wang, Su-xia,Zou, Wan-zhong,&Zhao, Ming-hui.(2009).Clinicopathological characteristics and outcomes of patients with crescentic lupus nephritis.KIDNEY INTERNATIONAL,76(3),307-317.
MLA Yu, Feng,et al."Clinicopathological characteristics and outcomes of patients with crescentic lupus nephritis".KIDNEY INTERNATIONAL 76.3(2009):307-317.
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