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学科主题: 临床医学
题名:
Image-Guided Percutaneous I-125 Seed Implantation as a Salvage Treatment for Recurrent Soft Tissue Sarcomas After Surgery and Radiotherapy
作者: Li, Jinna1; Wang, Junjie1; Meng, Na1; Qu, Ang1; Yuan, Huishu2; Liu, Chen2; Ran, Weiqiang3; Jiang, Yuliang1
关键词: CT ; I-125 seed implantation ; radiotherapy ; recurrent soft tissue sarcoma ; surgery ; ultrasound ; outcome
刊名: CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS
发表日期: 2011-02-01
DOI: 10.1089/cbr.2010.0847
卷: 26, 期:1, 页:113-120
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Medicine, Research & Experimental ; Pharmacology & Pharmacy ; Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]: Oncology ; Research & Experimental Medicine ; Pharmacology & Pharmacy ; Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]: EXTERNAL-BEAM RADIOTHERAPY ; FUNCTION-SAVING RESECTION ; RADIATION-THERAPY ; WOUND COMPLICATIONS ; INTRAOPERATIVE BRACHYTHERAPY ; INTERSTITIAL BRACHYTHERAPY ; ADJUVANT BRACHYTHERAPY ; SURGICAL RESECTION ; RANDOMIZED-TRIAL ; LOCAL-CONTROL
英文摘要:

The purpose of this study was to evaluate the safety and efficacy of percutaneous iodine-125 (I-125) seed implantation using computed tomography (CT) or ultrasound guidance in the treatment of recurrent soft tissue malignancies after surgery and radiotherapy. From February 2002 to September 2009, 18 patients with recurrent soft tissue sarcomas were treated under ultrasound or CT guidance. The actuarial median number of I-125 seeds implanted was 35 (range, 6-129), and the actuarial D90 of the implanted I-125 seeds ranged from 107.9 to 204.4 Gy (median, 147.1 Gy). The activity of the seeds ranged from 0.4 to 0.8 mCi (median, 0.7mCi). Follow-up times ranged from 4 to 78 months (median, 20 months). The median local control was 41 months (95% CI, 15.9-66.1 months). The 1-, 2-, 3-, 4-, and 5-year local controls were 78.8%, 78.8%, 78.8%, 26.3%, and 0%, respectively. The median survival was 32 months (95% CI, 16-48 months). The actuarial 1-, 2-, 3-, 4-, and 5-year survivals were 76.6%, 61.3%, 39.4%, 39.4%, and 39.4%, respectively. Seven (7) patients (38.9%) experienced recurrence after seed implantation. Six (6) patients (33.3%) died of distant metastases and 1 died of stroke. Two (2) patients developed ulceration, 1 case caused by recurrence and another by a reaction of the skin to radiation. Percutaneous I-125 seed implantation for recurrent soft tissue malignancies under CT or ultrasound guidance is safe and is associated with high efficacy and low morbidity.

语种: 英语
WOS记录号: WOS:000287860900008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56181
Appears in Collections:北京大学第三临床医学院_肿瘤放疗科_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Ctr Canc, Dept Radiat Oncol, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 3, Dept Radiol, Beijing 100191, Peoples R China
3.Peking Univ, Hosp 3, Dept Ultrasound, Beijing 100191, Peoples R China

Recommended Citation:
Li, Jinna,Wang, Junjie,Meng, Na,et al. Image-Guided Percutaneous I-125 Seed Implantation as a Salvage Treatment for Recurrent Soft Tissue Sarcomas After Surgery and Radiotherapy[J]. CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS,2011,26(1):113-120.
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