|Is Early-onset in Major Depression a Predictor of Specific Clinical Features with More Impaired Social Function?|
|Liu, Yan-Hong1; Chen, Lin1; Su, Yun-Ai2,3; Fang, Yi-Ru4; Srisurapanont, Manit5; Hong, Jin Pyo6; Hatim, Ahmad7; Chua, Hong Choon8; Bautista, Dianne9; Si, Tian-Mei2,3|
|关键词||Age Onset Asia Clinical Features Major Depressive Disorder Social Function|
|刊名||CHINESE MEDICAL JOURNAL|
|收录类别||SCI ; SSCI|
|WOS标题词||Science & Technology|
|类目[WOS]||Medicine, General & Internal|
|研究领域[WOS]||General & Internal Medicine|
|关键词[WOS]||ADULT-ONSET ; DISORDER ; HISTORY ; RISK ; AGE ; ADOLESCENTS ; SUICIDALITY ; ADVERSITY ; LIFE|
Background: Early-onset major depressive disorder (MDD) (EOD) is often particularly malignant due to its special clinical features, accompanying impaired social function, protracted recovery time, and frequent recurrence. This study aimed to observe the effects of age onset on clinical characteristics and social function in MDD patients in Asia.
Methods: In total, 547 out-patients aged 18-65 years who were from 13 study sites in five Asian countries were included. These patients had MDD diagnose according to the Diagnostic and Statistical Manual of Mental Disorders, 4th Edition criteria. Clinical features and social function were assessed using Symptom Checklist-90-revised (SCL-90-R) and Sheehan Disability Scale (SDS). Quality of life was assessed by a 36-item Short-form Health Survey (SF-36). Analyses were performed using a continuous or dichotomous (cut-off: 30 years) age-of-onset indicator.
Results: Early-onset MDD (EOD, < 30 years) was associated with longer illness (P = 0.003), unmarried status (P < 0.001), higher neuroticism (P = 0.002) based on the SCL-90-R, and more limited social function and mental health (P = 0.006, P = 0.007) based on the SF-36 and SDS. The impairment of social function and clinical severity were more prominent at in-patients with younger onset ages. Special clinical features and more impaired social function and quality of life were associated with EOD, as in western studies.
Conclusions: EOD often follows higher levels of neuroticism. Age of onset of MDD may be a predictor of clinical features and impaired social function, allowing earlier diagnosis and treatment.
|作者单位||1.Peking Univ, Teaching Hosp, Beijing Huilongguan Hosp, Beijing 100096, Peoples R China|
2.Minist Mental Hlth, Key Lab Mental Hlth, Beijing 100191, Peoples R China
3.Peking Univ, Inst Mental Hlth, Beijing 100191, Peoples R China
4.Shanghai Jiao Tong Univ, Sch Med, Shanghai Mental Hlth Ctr, Div Mood Disorders, Shanghai 200025, Peoples R China
5.Chiang Mai Univ, Fac Med, Dept Psychiat, Chiang Mai 50000, Thailand
6.Asan Med Ctr, Fac Med, Dept Psychiat, Seoul, South Korea
7.Univ Malaya, Fac Med, Dept Psychol Med, Kuala Lumpur, Malaysia
8.Woodbridge Hosp, Inst Mental Hlth, Singapore, Singapore
9.Duke Natl Univ Singapore, Grad Sch Med, Off Clin Sci, Ctr Quantitat Med, Singapore, Singapore
|Liu, Yan-Hong,Chen, Lin,Su, Yun-Ai,et al. Is Early-onset in Major Depression a Predictor of Specific Clinical Features with More Impaired Social Function?[J]. CHINESE MEDICAL JOURNAL,2015,128(6):811-815.|
|APA||Liu, Yan-Hong.,Chen, Lin.,Su, Yun-Ai.,Fang, Yi-Ru.,Srisurapanont, Manit.,...&Si, Tian-Mei.(2015).Is Early-onset in Major Depression a Predictor of Specific Clinical Features with More Impaired Social Function?.CHINESE MEDICAL JOURNAL,128(6),811-815.|
|MLA||Liu, Yan-Hong,et al."Is Early-onset in Major Depression a Predictor of Specific Clinical Features with More Impaired Social Function?".CHINESE MEDICAL JOURNAL 128.6(2015):811-815.|