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学科主题: 药学
题名:
Pedicularioside A from Buddleia lindleyana inhibits cell death induced by 1-methyl-4-phenylpyridinium ions (MPP+) in primary cultures of rat mesencephalic neurons
作者: Li, Yan-Yun1; Lu, Jiang-Hai2; Li, Quan1; Zhao, Yu-Ying2,3; Pu, Xiao-Ping1,3
关键词: Parkinson&prime ; s disease ; pedicularioside A ; mesencephalic neurons ; MPP+ ; caspase-3 ; PARP
刊名: EUROPEAN JOURNAL OF PHARMACOLOGY
发表日期: 2008-01-28
DOI: 10.1016/j.ejphar.2007.10.052
卷: 579, 期:1-3, 页:134-140
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: PHENYLPROPANOID GLYCOSIDES ; PARKINSONS-DISEASE ; PHENYLETHANOID GLYCOSIDES ; DOPAMINE NEURONS ; PC12 CELLS ; MPTP MODEL ; APOPTOSIS ; NEUROTOXICITY ; TOXICITY ; BRAIN
英文摘要:

Parkinson′s disease is characterized by the progressive degeneration of midbrain dopaminergic neurons. Buddleia lindleyana is a traditional Chinese herb, commonly called Zui Yu Cao. The purification and identification of pedicularioside A and other phenylethanoid glycosides from this plant have been reported. However, their neuroprotective effects on the 1-methyl-4-phenylpyridinium ion (MPP+)-induced death of rat mesencephalic neuron primary cultures and the precise mechanism of this protection remains unclear. We used the 3-(4, 5-dimethylthiozol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay for cellular growth to examine the effects of five phenylethanoid glycosides isolated from B. lindleyana, including pedicularioside A, leucosceptoside A, isoacteoside, acteoside, and arenariside, on the viability of mesencephalic neurons treated with MPP+. Of the compounds tested, pedicularioside A exhibited the greatest degree of protection from MPP+-induced cell death. We also observed a marked increase in the number of tyrosine hydroxylase immunoreactive neurons. Pedicularioside A inhibited expression of the caspase-3 gene and cleavage of poly (ADP-ribose) polymerase (PARP) in cultures exposed to MPP+. Our results suggest that pedicularioside A has a neuroprotective effect to improve the survival of mesencephalic neurons (dopaminergic neurons and non-dopaminergic neurons). The mode of action appears to be the inhibition of caspase-3 gene expression, thereby protecting mesencephalic neurons from MPP+-induced cell death. (C) 2007 Elsevier B.V. All rights reserved.

语种: 英语
WOS记录号: WOS:000252979200017
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56195
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, Dept Mol & Cellular Pharmacol, Beijing 100083, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Dept Nat Med, Beijing 100083, Peoples R China
3.Peking Univ, Natl Key Res Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China

Recommended Citation:
Li, Yan-Yun,Lu, Jiang-Hai,Li, Quan,et al. Pedicularioside A from Buddleia lindleyana inhibits cell death induced by 1-methyl-4-phenylpyridinium ions (MPP+) in primary cultures of rat mesencephalic neurons[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2008,579(1-3):134-140.
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