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Pedicularioside A from Buddleia lindleyana inhibits cell death induced by 1-methyl-4-phenylpyridinium ions (MPP+) in primary cultures of rat mesencephalic neurons
Li, Yan-Yun1; Lu, Jiang-Hai2; Li, Quan1; Zhao, Yu-Ying2,3; Pu, Xiao-Ping1,3
关键词Parkinson&Prime s Disease Pedicularioside a Mesencephalic Neurons Mpp++ Caspase-3 Parp
刊名EUROPEAN JOURNAL OF PHARMACOLOGY
2008-01-28
DOI10.1016/j.ejphar.2007.10.052
579期:1-3页:134-140
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]PHENYLPROPANOID GLYCOSIDES ; PARKINSONS-DISEASE ; PHENYLETHANOID GLYCOSIDES ; DOPAMINE NEURONS ; PC12 CELLS ; MPTP MODEL ; APOPTOSIS ; NEUROTOXICITY ; TOXICITY ; BRAIN
英文摘要

Parkinson′s disease is characterized by the progressive degeneration of midbrain dopaminergic neurons. Buddleia lindleyana is a traditional Chinese herb, commonly called Zui Yu Cao. The purification and identification of pedicularioside A and other phenylethanoid glycosides from this plant have been reported. However, their neuroprotective effects on the 1-methyl-4-phenylpyridinium ion (MPP+)-induced death of rat mesencephalic neuron primary cultures and the precise mechanism of this protection remains unclear. We used the 3-(4, 5-dimethylthiozol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay for cellular growth to examine the effects of five phenylethanoid glycosides isolated from B. lindleyana, including pedicularioside A, leucosceptoside A, isoacteoside, acteoside, and arenariside, on the viability of mesencephalic neurons treated with MPP+. Of the compounds tested, pedicularioside A exhibited the greatest degree of protection from MPP+-induced cell death. We also observed a marked increase in the number of tyrosine hydroxylase immunoreactive neurons. Pedicularioside A inhibited expression of the caspase-3 gene and cleavage of poly (ADP-ribose) polymerase (PARP) in cultures exposed to MPP+. Our results suggest that pedicularioside A has a neuroprotective effect to improve the survival of mesencephalic neurons (dopaminergic neurons and non-dopaminergic neurons). The mode of action appears to be the inhibition of caspase-3 gene expression, thereby protecting mesencephalic neurons from MPP+-induced cell death. (C) 2007 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000252979200017
引用统计
被引频次:25[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56195
专题北京大学药学院
北京大学药学院_分子与细胞药理学系
作者单位1.Peking Univ, Sch Pharmaceut Sci, Dept Mol & Cellular Pharmacol, Beijing 100083, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Dept Nat Med, Beijing 100083, Peoples R China
3.Peking Univ, Natl Key Res Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
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GB/T 7714
Li, Yan-Yun,Lu, Jiang-Hai,Li, Quan,et al. Pedicularioside A from Buddleia lindleyana inhibits cell death induced by 1-methyl-4-phenylpyridinium ions (MPP+) in primary cultures of rat mesencephalic neurons[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2008,579(1-3):134-140.
APA Li, Yan-Yun,Lu, Jiang-Hai,Li, Quan,Zhao, Yu-Ying,&Pu, Xiao-Ping.(2008).Pedicularioside A from Buddleia lindleyana inhibits cell death induced by 1-methyl-4-phenylpyridinium ions (MPP+) in primary cultures of rat mesencephalic neurons.EUROPEAN JOURNAL OF PHARMACOLOGY,579(1-3),134-140.
MLA Li, Yan-Yun,et al."Pedicularioside A from Buddleia lindleyana inhibits cell death induced by 1-methyl-4-phenylpyridinium ions (MPP+) in primary cultures of rat mesencephalic neurons".EUROPEAN JOURNAL OF PHARMACOLOGY 579.1-3(2008):134-140.
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